CDKN2D
CDKN2D (Cyclin dependent kinase inhibitor 2D) هوَ بروتين يُشَفر بواسطة جين CDKN2D في الإنسان.[1][2]
الوظيفة
[عدل]![[أيقونة]](http://upload.wikimedia.org/wikipedia/commons/thumb/d/dd/Crystal_xedit.svg/40px-Crystal_xedit.svg.png){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
[عدل] | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
[عدل]- ^ Okuda T، Hirai H، Valentine VA، Shurtleff SA، Kidd VJ، Lahti JM، Sherr CJ، Downing JR (مارس 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics. ج. 29 ع. 3: 623–30. DOI:10.1006/geno.1995.9957. PMID:8575754.
- ^ "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)". مؤرشف من الأصل في 2010-12-05.
قراءة متعمقة
[عدل]- Hirai H، Roussel MF، Kato JY، وآخرون (1995). "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6". Mol. Cell. Biol. ج. 15 ع. 5: 2672–81. PMC:230497. PMID:7739547.
- Chan FK، Zhang J، Cheng L، وآخرون (1995). "Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4". Mol. Cell. Biol. ج. 15 ع. 5: 2682–8. PMC:230498. PMID:7739548.
- Guan KL، Jenkins CW، Li Y، وآخرون (1996). "Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4". Mol. Biol. Cell. ج. 7 ع. 1: 57–70. DOI:10.1091/mbc.7.1.57. PMC:278612. PMID:8741839.
- Schwaller J، Pabst T، Koeffler HP، وآخرون (1997). "Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells". Leukemia. ج. 11 ع. 1: 54–63. DOI:10.1038/sj.leu.2400522. PMID:9001419.
- Russo AA، Tong L، Lee JO، وآخرون (1998). "Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a". Nature. ج. 395 ع. 6699: 237–43. DOI:10.1038/26155. PMID:9751050.
- Brotherton DH، Dhanaraj V، Wick S، وآخرون (1998). "Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d". Nature. ج. 395 ع. 6699: 244–50. DOI:10.1038/26164. PMID:9751051.
- Baumgartner R، Fernandez-Catalan C، Winoto A، وآخرون (1998). "Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a". Structure. ج. 6 ع. 10: 1279–90. DOI:10.1016/S0969-2126(98)00128-2. PMID:9782052.
- Schreiber M، Muller WJ، Singh G، Graham FL (1999). "Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity". Oncogene. ج. 18 ع. 9: 1663–76. DOI:10.1038/sj.onc.1202466. PMID:10208428.
- Newton Bishop JA، Harland M، Bennett DC، وآخرون (1999). "Mutation testing in melanoma families: INK4A, CDK4 and INK4D". Br. J. Cancer. ج. 80 ع. 1–2: 295–300. DOI:10.1038/sj.bjc.6690354. PMC:2363010. PMID:10390011.
- Zindy F، Cunningham JJ، Sherr CJ، وآخرون (1999). "Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. ج. 96 ع. 23: 13462–7. DOI:10.1073/pnas.96.23.13462. PMC:23970. PMID:10557343.
- Thullberg M، Bartkova J، Khan S، وآخرون (2000). "Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors". FEBS Lett. ج. 470 ع. 2: 161–6. DOI:10.1016/S0014-5793(00)01307-7. PMID:10734227.
- Bartkova J، Thullberg M، Rajpert-De Meyts E، وآخرون (2000). "Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis". Oncogene. ج. 19 ع. 36: 4146–50. DOI:10.1038/sj.onc.1203769. PMID:10962575.
- Fink JR، LeBien TW (2001). "Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors". Exp. Hematol. ج. 29 ع. 4: 490–8. DOI:10.1016/S0301-472X(01)00619-1. PMID:11301189.
- Zeeb M، Rösner H، Zeslawski W، وآخرون (2002). "Protein folding and stability of human CDK inhibitor p19(INK4d)". J. Mol. Biol. ج. 315 ع. 3: 447–57. DOI:10.1006/jmbi.2001.5242. PMID:11786024.
- Matsuzaki Y، Miyazawa K، Yokota T، وآخرون (2002). "Molecular cloning and characterization of the human p19(INK4d) gene promoter". FEBS Lett. ج. 517 ع. 1–3: 272–6. DOI:10.1016/S0014-5793(02)02647-9. PMID:12062451.
- Arcellana-Panlilio MY، Egeler RM، Ujack E، وآخرون (2002). "Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors". Genes Chromosomes Cancer. ج. 35 ع. 2: 176–81. DOI:10.1002/gcc.10108. PMID:12203782.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Gevaert K، Goethals M، Martens L، وآخرون (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. ج. 21 ع. 5: 566–9. DOI:10.1038/nbt810. PMID:12665801.
- Komata T، Kanzawa T، Takeuchi H، وآخرون (2004). "Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells". Br. J. Cancer. ج. 88 ع. 8: 1277–80. DOI:10.1038/sj.bjc.6600862. PMC:2747579. PMID:12698196.
