High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and Challenges (Q38498286)

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scientific article published on 22 May 2015

Language	Label	Description	Also known as
English	High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and Challenges	scientific article published on 22 May 2015

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

1 reference

Europe PubMed Central

High-Throughput Silencing Using the CRISPR-Cas9 System: A Review of the Benefits and Challenges (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

0 references

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CRISPR-Cas method

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based on heuristic

inferred from title

author name string

Mark Wade

1

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

publication date

22 May 2015

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

Journal of Biomolecular Screening

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Europe PubMed Central

PubMed publication ID

3 September 2017

20

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

1027-1039

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

CRISPR-based adaptive and heritable immunity in prokaryotes

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Diversity of CRISPR systems in the euryarchaeal Pyrococcales

1 reference

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21 January 2018

Unravelling the structural and mechanistic basis of CRISPR-Cas systems

1 reference

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21 January 2018

BurrH: a new modular DNA binding protein for genome engineering.

1 reference

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21 January 2018

Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus.

1 reference

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21 January 2018

Cutting it close: CRISPR-associated endoribonuclease structure and function

1 reference

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21 January 2018

Genetic screens in human cells using the CRISPR-Cas9 system

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome-scale CRISPR-Cas9 knockout screening in human cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

1 reference

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21 January 2018

Improved vectors and genome-wide libraries for CRISPR screening

1 reference

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21 January 2018

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

1 reference

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21 January 2018

High-efficiency targeted editing of large viral genomes by RNA-guided nucleases

1 reference

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21 January 2018

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

A protein-tagging system for signal amplification in gene expression and fluorescence imaging

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Improved genome editing in human cell lines using the CRISPR method

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Inducible in vivo genome editing with CRISPR-Cas9

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Haploid genetic screens in human cells identify host factors used by pathogens

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Generation of iPSCs from cultured human malignant cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Derivation of haploid embryonic stem cells from mouse embryos

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

A genetic screen using the PiggyBac transposon in haploid cells identifies Parp1 as a mediator of olaparib toxicity

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Selection of hyperfunctional siRNAs with improved potency and specificity

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Discovery of a dicer-independent, cell-type dependent alternate targeting sequence generator: implications in gene silencing & pooled RNAi screens

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Systematic analysis of RNAi reports identifies dismal commonality at gene-level and reveals an unprecedented enrichment in pooled shRNA screens

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Comparative analysis of RNAi screening technologies at genome-scale reveals an inherent processing inefficiency of the plasmid-based shRNA hairpin

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Gene targeting with viral vectors

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Adeno-associated virus biology

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Targeted genome regulation and modification using transcription activator-like effectors

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Multiplex CRISPR/Cas9-based genome engineering from a single lentiviral vector

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Human gene targeting by viral vectors

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Simple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

CRISPR genome engineering and viral gene delivery: a case of mutual attraction

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

CRISPR/Cas9-mediated genome engineering: an adeno-associated viral (AAV) vector toolbox

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Correction of a genetic disease in mouse via use of CRISPR-Cas9.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

DNA sequencing and CRISPR-Cas9 gene editing for target validation in mammalian cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Understanding functional miRNA-target interactions in vivo by site-specific genome engineering.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Mapping of signaling networks through synthetic genetic interaction analysis by RNAi

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Measuring genetic interactions in human cells by RNAi and imaging

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

The multilayered complexity of ceRNA crosstalk and competition

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Circular RNAs: diversity of form and function

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Programmable RNA recognition and cleavage by CRISPR/Cas9.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

DNA targeting specificity of RNA-guided Cas9 nucleases

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Target specificity of the CRISPR-Cas9 system.

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Synthetic Genetic Array (SGA) Analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe

1 reference

https://api.crossref.org/works/10.1177%2F1087057115587916

21 January 2018

Identifiers

10.1177/1087057115587916

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 September 2017

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