Unravelling the structural and mechanistic basis of CRISPR-Cas systems (Q34041195)

30 July 2017

title

Unravelling the structural and mechanistic basis of CRISPR-Cas systems (English)

1 reference

30 July 2017

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John van der Oost

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Ryan Jackson

series ordinal

object named as

Ryan N Jackson

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30 July 2017

Blake Wiedenheft

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30 July 2017

Edze R Westra

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30 July 2017

language of work or name

English

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publication date

9 June 2014

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Nature Reviews Microbiology

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

479-492

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Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

30 July 2017

cites work

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Degenerate target sites mediate rapid primed CRISPR adaptation.

5 July 2018

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A CRISPR method for genome engineering

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

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5 July 2018

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5 July 2018

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5 July 2018

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Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage

5 July 2018

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5 July 2018

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Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

5 July 2018

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Requirements for a successful defence reaction by the CRISPR-Cas subtype I-B system.

5 July 2018

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The basic building blocks and evolution of CRISPR-CAS systems

5 July 2018

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Genetic characterization of antiplasmid immunity through a type III-A CRISPR-Cas system

5 July 2018

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Toroidal Structure and DNA Cleavage by the CRISPR-Associated [4Fe-4S] Cluster Containing Cas4 Nuclease SSO0001 from Sulfolobus solfataricus

5 July 2018

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Structure and RNA-binding properties of the Type III-A CRISPR-associated protein Csm3

5 July 2018

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Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

5 July 2018

1 reference

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Structure of an RNA silencing complex of the CRISPR-Cas immune system.

5 July 2018

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Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus

5 July 2018

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Structure of the CRISPR interference complex CSM reveals key similarities with cascade

5 July 2018

1 reference

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Type I-E CRISPR-cas systems discriminate target from non-target DNA through base pairing-independent PAM recognition

5 July 2018

1 reference

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Differential translation tunes uneven production of operon-encoded proteins

5 July 2018

1 reference

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Revenge of the phages: defeating bacterial defences

5 July 2018

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A ruler protein in a complex for antiviral defense determines the length of small interfering CRISPR RNAs

5 July 2018

1 reference

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Rapid evolution of the human gut virome

5 July 2018

1 reference

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CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance.

5 July 2018

1 reference

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CRISPR interference: a structural perspective

5 July 2018

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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

5 July 2018

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Cytotoxic chromosomal targeting by CRISPR/Cas systems can reshape bacterial genomes and expel or remodel pathogenicity islands

5 July 2018

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Double-strand DNA end-binding and sliding of the toroidal CRISPR-associated protein Csn2.

5 July 2018

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Crystal structure of the Cmr2-Cmr3 subcomplex in the CRISPR-Cas RNA silencing effector complex

5 July 2018

1 reference

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Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing

5 July 2018

1 reference

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Conservation and variability in the structure and function of the Cas5d endoribonuclease in the CRISPR-mediated microbial immune system

5 July 2018

1 reference

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CRISPR-mediated adaptive immune systems in bacteria and archaea

5 July 2018

1 reference

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Comparative genomics of defense systems in archaea and bacteria

5 July 2018

1 reference

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Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

5 July 2018

1 reference

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A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

5 July 2018

1 reference

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CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli

5 July 2018

1 reference

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Protospacer recognition motifs: mixed identities and functional diversity

5 July 2018

1 reference

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Structure of the Cmr2-Cmr3 Subcomplex of the Cmr RNA Silencing Complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

5 July 2018

1 reference

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In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus.

5 July 2018

1 reference

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A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus.

5 July 2018

1 reference

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In vivo protein interactions and complex formation in the Pectobacterium atrosepticum subtype I-F CRISPR/Cas System

5 July 2018

1 reference

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Target motifs affecting natural immunity by a constitutive CRISPR-Cas system in Escherichia coli.

5 July 2018

1 reference

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The CRISPRs, they are a-changin': how prokaryotes generate adaptive immunity

5 July 2018

1 reference

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The CRISPR associated protein Cas4 Is a 5' to 3' DNA exonuclease with an iron-sulfur cluster

5 July 2018

1 reference

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Cas5d processes pre-crRNA and is a member of a larger family of CRISPR RNA endonucleases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Cascade-mediated binding and bending of negatively supercoiled DNA.

5 July 2018

1 reference

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

5 July 2018

1 reference

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Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein

5 July 2018

1 reference

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Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa

5 July 2018

1 reference

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Cleavage of phage DNA by the Streptococcus thermophilus CRISPR3-Cas system

5 July 2018

1 reference

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Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

5 July 2018

1 reference

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Selective and hyperactive uptake of foreign DNA by adaptive immune systems of an archaeon via two distinct mechanisms.

5 July 2018

1 reference

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Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system

5 July 2018

1 reference

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Identification, structural, and biochemical characterization of a group of large Csn2 proteins involved in CRISPR-mediated bacterial immunity

5 July 2018

1 reference

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

5 July 2018

1 reference

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Crystal Structure of the Largest Subunit of a Bacterial RNA-guided Immune Complex and Its Role in DNA Target Binding

5 July 2018

1 reference

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CRISPR interference directs strand specific spacer acquisition

5 July 2018

1 reference

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Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA

5 July 2018

1 reference

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Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System

5 July 2018

1 reference

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CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Crystal Structure of Streptococcus pyogenes Csn2 Reveals Calcium-Dependent Conformational Changes in Its Tertiary and Quaternary Structure

5 July 2018

1 reference

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Crystal structure of Cmr2 suggests a nucleotide cyclase-related enzyme in type III CRISPR-Cas systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Characterization of the CRISPR/Cas subtype I-A system of the hyperthermophilic crenarchaeon Thermoproteus tenax

5 July 2018

1 reference

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Structure of the Cmr2 Subunit of the CRISPR-Cas RNA Silencing Complex

5 July 2018

1 reference

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Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli

5 July 2018

1 reference

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Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

5 July 2018

1 reference

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RNA-guided genetic silencing systems in bacteria and archaea

5 July 2018

1 reference

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Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs.

5 July 2018

1 reference

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Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

5 July 2018

1 reference

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Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Structures of the RNA-guided surveillance complex from a bacterial immune system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

The human gut virome: inter-individual variation and dynamic response to diet

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Structural and Biochemical Analysis of Nuclease Domain of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Protein 3 (Cas3)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Crystal structure of clustered regularly interspaced short palindromic repeats (CRISPR)-associated Csn2 protein revealed Ca2+-dependent double-stranded DNA binding activity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Recognition and maturation of effector RNAs in a CRISPR interference pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Evolution and classification of the CRISPR-Cas systems

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Structural basis for CRISPR RNA-guided DNA recognition by Cascade

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair

5 July 2018

1 reference

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Structure of a CRISPR-associated protein Cas2 fromDesulfovibrio vulgaris

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Binding and cleavage of CRISPR RNA by Cas6

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Self-targeting by CRISPR: gene regulation or autoimmunity?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Self versus non-self discrimination during CRISPR RNA-directed immunity.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

CRISPR-based adaptive and heritable immunity in prokaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

CRISPR families of the crenarchaeal genus Sulfolobus: bidirectional transcription and dynamic properties

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Small CRISPR RNAs guide antiviral defense in prokaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Phage response to CRISPR-encoded resistance in Streptococcus thermophilus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Rapidly evolving CRISPRs implicated in acquired resistance of microorganisms to viruses.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Marine viruses--major players in the global ecosystem

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Evolutionary conservation of sequence and secondary structures in CRISPR repeats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Identification of genes that are associated with DNA repeats in prokaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

The structure of the E. coli recA protein monomer and polymer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4225775

Same same but different: new structural insight into CRISPR-Cas complexes.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3279

The repetitive DNA elements called CRISPRs and their associated genes: evidence of horizontal transfer among prokaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3279

The crystal structure of the CRISPR-associated protein Csn2 from Streptococcus agalactiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3279

Csy4 is responsible for CRISPR RNA processing in Pectobacterium atrosepticum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3279

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO3279

21 January 2018

Identifiers

DOI

10.1038/NRMICRO3279

1 reference

Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference