Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity (Q29615792)

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8 March 2020

title

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity (English)

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30 April 2017

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8 March 2020

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8 March 2020

Jonathan S. Gootenberg

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8 March 2020

F Ann Ran

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8 March 2020

Chie-Yu Lin

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8 March 2020

Silvana Konermann

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8 March 2020

Alexandro E Trevino

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8 March 2020

David A Scott

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8 March 2020

Azusa Inoue

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8 March 2020

Shogo Matoba

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8 March 2020

Yi Zhang

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8 March 2020

Feng Zhang

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language of work or name

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30 April 2017

publication date

29 August 2013

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full work available at URL

8 March 2020

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856256

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8 March 2020

volume

154

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8 March 2020

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8 March 2020

page(s)

1380-1389

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

8 March 2020

cites work

1 reference

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DNA targeting specificity of RNA-guided Cas9 nucleases

30 April 2017

1 reference

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Heritable genome editing in C. elegans via a CRISPR-Cas9 system

30 April 2017

1 reference

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

30 April 2017

1 reference

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

30 April 2017

1 reference

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RNA-programmed genome editing in human cells

30 April 2017

1 reference

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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

30 April 2017

1 reference

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RNA-guided editing of bacterial genomes using CRISPR-Cas systems

30 April 2017

1 reference

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RNA-guided human genome engineering via Cas9

30 April 2017

1 reference

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Multiplex genome engineering using CRISPR/Cas systems

30 April 2017

1 reference

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

30 April 2017

1 reference

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

30 April 2017

1 reference

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Targeted genome editing across species using ZFNs and TALENs

30 April 2017

1 reference

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CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

30 April 2017

1 reference

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Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

30 April 2017

1 reference

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A TALE nuclease architecture for efficient genome editing

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Genome editing with engineered zinc finger nucleases

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Targeted mutagenesis in the silkworm Bombyx mori using zinc finger nuclease mRNA injection

30 April 2017

1 reference

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Targeting DNA double-strand breaks with TAL effector nucleases

30 April 2017

1 reference

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CRISPR/Cas, the immune system of bacteria and archaea

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Breaking the code of DNA binding specificity of TAL-type III effectors

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

A simple cipher governs DNA recognition by TAL effectors

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Knockout rats via embryo microinjection of zinc-finger nucleases

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

An improved zinc-finger nuclease architecture for highly specific genome editing

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Chimeric nucleases stimulate gene targeting in human cells

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Mammalian base excision repair: the forgotten archangel

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

A TALEN genome-editing system for generating human stem cell-based disease models

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Efficient TALEN-mediated gene knockout in livestock

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Dissecting neural function using targeted genome engineering technologies.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

FLASH assembly of TALENs for high-throughput genome editing

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

A transcription activator-like effector toolbox for genome engineering

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

CRISPR/Cas system and its role in phage-bacteria interactions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3856256

10.1016/J.CELL.2013.08.021

3 June 2018

Identifiers

DOI

3 references

PubMed

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8 March 2020

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