Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. (Q33849553)

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English	Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing.	scientific article

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Europe PubMed Central

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4082799

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

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21 March 2020

title

Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing (English)

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Europe PubMed Central

PMC publication ID

4082799

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

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21 March 2020

main subject

CRISPR

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Cas9

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whole genome sequencing

1 reference

based on heuristic

inferred from title

CRISPR-Cas method

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based on heuristic

inferred from title

author

Serkan Erdin

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7

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Europe PubMed Central

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4082799

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

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21 March 2020

Ryan L Collins

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4

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4082799

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21 March 2020

Michael E. Talkowski

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9

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4082799

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21 March 2020

Adrian Veres

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1

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Adrian Veres

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4082799

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21 March 2020

Chad A. Cowan

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8

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Chad A Cowan

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4082799

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21 March 2020

author name string

Bridget S Gosis

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2

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4082799

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21 March 2020

Qiurong Ding

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3

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4082799

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21 March 2020

Ashok Ragavendran

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5

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4082799

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21 March 2020

Harrison Brand

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6

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4082799

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21 March 2020

Kiran Musunuru

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10

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4082799

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21 March 2020

language of work or name

English

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publication date

1 July 2014

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4082799

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21 March 2020

published in

Cell Stem Cell

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4082799

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21 March 2020

volume

15

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4082799

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21 March 2020

issue

1

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4082799

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21 March 2020

page(s)

27-30

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4082799

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21 March 2020

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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

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5 July 2018

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

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PubMed Central

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

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5 July 2018

DNA targeting specificity of RNA-guided Cas9 nucleases

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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Genome editing of human pluripotent stem cells to generate human cellular disease models

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5 July 2018

Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs

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5 July 2018

RNA-programmed genome editing in human cells

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PubMed Central

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5 July 2018

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

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PubMed Central

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5 July 2018

RNA-guided human genome engineering via Cas9

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PubMed Central

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5 July 2018

Multiplex genome engineering using CRISPR/Cas systems

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5 July 2018

A TALEN genome-editing system for generating human stem cell-based disease models

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

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A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

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Genetic engineering of human pluripotent cells using TALE nucleases

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5 July 2018

Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.

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Somatic coding mutations in human induced pluripotent stem cells

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Copy number variation and selection during reprogramming to pluripotency

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A TALE nuclease architecture for efficient genome editing

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Identifiers

DOI

10.1016/J.STEM.2014.04.020

1 reference

stated in

Europe PubMed Central

PMC publication ID

4082799

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

retrieved

21 March 2020

PMC publication ID

4082799

1 reference

stated in

Europe PubMed Central

PMC publication ID

4082799

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

retrieved

21 March 2020

PubMed publication ID

24996167

1 reference

stated in

Europe PubMed Central

PMC publication ID

4082799

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24996167%20AND%20SRC:MED&resulttype=core&format=json

retrieved

21 March 2020

ResearchGate publication ID

261629615

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