A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin (Q24630256)

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English	A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin	scientific article

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A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin (English)

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David M. Sabatini

6

object named as

David M Sabatini

author given names

David M

author last names

Sabatini

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PubMed publication ID

19 October 2023

author name string

Jan H Reiling

1

author given names

Jan H

author last names

Reiling

1 reference

PubMed publication ID

19 October 2023

Clary B Clish

2

author given names

Clary B

author last names

Clish

1 reference

PubMed publication ID

19 October 2023

Jan E Carette

3

author given names

Jan E

author last names

Carette

1 reference

PubMed publication ID

19 October 2023

Malini Varadarajan

4

author given names

Malini

author last names

Varadarajan

1 reference

PubMed publication ID

19 October 2023

Thijn R Brummelkamp

5

author given names

Thijn R

author last names

Brummelkamp

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PubMed publication ID

19 October 2023

language of work or name

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publication date

19 July 2011

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Proceedings of the National Academy of Sciences of the United States of America

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108

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29

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11756-65

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Haploid genetic screens in human cells identify host factors used by pathogens

1 reference

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7 April 2017

Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis

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7 April 2017

Major facilitator superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

7 April 2017

Signal integration in the endoplasmic reticulum unfolded protein response

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7 April 2017

Identification of mitogen-activated protein kinase signaling pathways that confer resistance to endoplasmic reticulum stress in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

7 April 2017

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

7 April 2017

Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue

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7 April 2017

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

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7 April 2017

Roles of N-linked glycans in the endoplasmic reticulum

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7 April 2017

Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen

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27 September 2017

MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

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27 September 2017

A 3D structure model of the melibiose permease of Escherichia coli represents a distinctive fold for Na+ symporters

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Structure, expression, and regulation of UDP-GlcNAc: dolichol phosphate GlcNAc-1-phosphate transferase (DPAGT1).

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27 September 2017

Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Effect of tunicamycin on Candida albicans biofilm formation and maintenance

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27 September 2017

A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2.

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27 September 2017

Ins and outs of major facilitator superfamily antiporters.

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27 September 2017

Functional roles of N-glycans in cell signaling and cell adhesion in cancer

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27 September 2017

Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Xenobiotic transporter-adaptor network

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Combination of tunicamycin with anticancer drugs synergistically enhances their toxicity in multidrug-resistant human ovarian cystadenocarcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Controlling N-linked glycan site occupancy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Modeling bacterial UDP-HexNAc: polyprenol-P HexNAc-1-P transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

The major facilitator superfamily

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Arg-52 in the melibiose carrier of Escherichia coli is important for cation-coupled sugar transport and participates in an intrahelical salt bridge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Inhibition of N-linked glycosylation by tunicamycin enhances sensitivity to cisplatin in human head-and-neck carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Short exposures to tunicamycin induce apoptosis in SV40-transformed but not in normal human fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Cation and sugar selectivity determinants in a novel family of transport proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Modes of action of tunicamycin, liposidomycin B, and mureidomycin A: inhibition of phospho-N-acetylmuramyl-pentapeptide translocase from Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Mutagenesis of acidic residues in putative membrane-spanning segments of the melibiose permease of Escherichia coli. II. Effect on cationic selectivity and coupling properties

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Mutagenesis of acidic residues in putative membrane-spanning segments of the melibiose permease of Escherichia coli. I. Effect on Na(+)-dependent transport and binding properties

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Tunicamycin inhibits ganglioside biosynthesis in neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Tunicamycin inhibits ganglioside biosynthesis in rat liver Golgi apparatus by blocking sugar nucleotide transport across the membrane vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Selection of tunicamycin-resistant Chinese hamster ovary cells with increased N-acetylglucosaminyltransferase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Melibiose permease of Escherichia coli: mutation of aspartic acid 55 in putative helix II abolishes activation of sugar binding by Na+ ions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Topographical orientation in microsomal vesicles of the N-acetylglucosaminyltransferases which catalyze the biosynthesis of N-acetylglucosaminylpyrophosphoryldolichol and N-acetylglucosaminyl-N-acetylglucosaminylpyrophosphoryldolichol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Effect of phloretin on the permeability of thin lipid membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Changes in surface properties of normal and transformed cells caused by tunicamycin, an inhibitor of protein glycosylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

Tunicamycin inhibits glycosylation and multiplication of Sindbis and vesicular stomatitis viruses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

27 September 2017

A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

The C-terminus is critical for the functional expression of the human serotonin transporter

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

The effect of binding of chlorpromazine and chloroquine to ion transporting ATPases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Selective cytotoxicity of purified homologues of tunicamycin on transformed BALB/3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Effect of tunicamycin on the synthesis of macromolecules in cultures of chick embryo fibroblasts infected with Newcastle disease virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

The effects of glycosylation inhibitors on the proliferation of a spontaneously transformed cell line (3T6) in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Effects of chlorpromazine on Na+-K+-ATPase pumping and solute transport in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Tunicamycin inhibition of (3H) glucosamine incorporation into yeast glycoproteins: binding of tunicamycin and interaction with phospholipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

N-Acetylglucosamine-1-phosphate transferase from hen oviduct: solubilization, characterization, and inhibition by tunicamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Hamster UDP-N-acetylglucosamine:dolichol-P N-acetylglucosamine-1-P transferase has multiple transmembrane spans and a critical cytosolic loop.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

30 May 2018

Biosynthesis of tunicamycin and metabolic origin of the 11-carbon dialdose sugar, tunicamine

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018098108

21 January 2018

Active site mapping of MraY, a member of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily, catalyzing the first membrane step of peptidoglycan biosynthesis

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018098108

21 January 2018

The effect of modifications of the charged residues in the transmembrane helices on the transport activity of the melibiose carrier of Escherichia coli

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018098108

21 January 2018

Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018098108

21 January 2018

Differential requirement of unfolded protein response pathway for calreticulin expression in Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018098108

21 January 2018

Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1018098108

21 January 2018

Physiological evidence for an interaction between helices II and XI in the melibiose carrier of Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

28 November 2018

Effect of tunicamycin on 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

28 November 2018

Biochemical effects and therapeutic potential of tunicamycin in murine L1210 leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3141996

28 November 2018

Melibiose carrier of Escherichia coli: use of cysteine mutagenesis to identify the amino acids on the hydrophilic face of transmembrane helix 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677192

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship of the structure and biological activity of the natural homologues of tunicamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677192

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential incorporation of tunicamycin, an antiviral antibiotic containing glucosamine, into the cell membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677192

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tunicamycin inhibits proteoglycan synthesis in rat ovarian granulosa cells in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677192

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dynamic protein palmitoylation in intact cells with tunicamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677192

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/21677192

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1018098108

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2011PNAS..10811756R

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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