GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures (Q58568628)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30410121%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

title

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures (English)

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2 May 2020

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Kurt Wüthrich

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30410121%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Matthew T Eddy

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Ichio Shimada

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2 May 2020

Takumi Ueda

series ordinal

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2 May 2020

Yutaka Kofuku

series ordinal

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2 May 2020

language of work or name

English

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publication date

9 November 2018

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Nature Reviews Drug Discovery

2 May 2020

published in

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2 May 2020

volume

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2 May 2020

issue

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2 May 2020

page(s)

59-82

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Trends in the exploitation of novel drug targets

2 May 2020

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31 March 2020

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31 March 2020

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31 March 2020

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.

31 March 2020

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Observing biological dynamics at atomic resolution using NMR.

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31 March 2020

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Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion

31 March 2020

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Conductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane region

31 March 2020

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Functional dynamics of cell surface membrane proteins

31 March 2020

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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

31 March 2020

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

31 March 2020

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Efficacy of the β₂-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

31 March 2020

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Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

31 March 2020

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Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

31 March 2020

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

31 March 2020

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Role of detergents in conformational exchange of a G protein-coupled receptor

31 March 2020

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The dynamic process of β(2)-adrenergic receptor activation

31 March 2020

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The role of ligands on the equilibria between functional states of a G protein-coupled receptor

31 March 2020

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β₂-adrenergic receptor activation by agonists studied with ¹⁹F NMR spectroscopy

31 March 2020

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Functional dynamics of deuterated β2 -adrenergic receptor in lipid bilayers revealed by NMR spectroscopy

31 March 2020

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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

31 March 2020

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β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

31 March 2020

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Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR.

31 March 2020

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Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

31 March 2020

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Ligand modulation of sidechain dynamics in a wild-type human GPCR.

31 March 2020

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Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor

31 March 2020

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Propagation of conformational changes during μ-opioid receptor activation

31 March 2020

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Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor

31 March 2020

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Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer.

31 March 2020

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Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations.

31 March 2020

1 reference

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NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor

31 March 2020

1 reference

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Interaction of Monomeric Interleukin-8 with CXCR1 Mapped by Proton-Detected Fast MAS Solid-State NMR.

31 March 2020

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Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy

31 March 2020

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Drug design for G-protein-coupled receptors by a ligand-based NMR method

31 March 2020

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The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors

31 March 2020

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Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding

31 March 2020

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Dynamic regulation of GDP binding to G proteins revealed by magnetic field-dependent NMR relaxation analyses.

31 March 2020

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Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin

31 March 2020

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Dependence of amino acid side chain 13C shifts on dihedral angle: application to conformational analysis

31 March 2020

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Conformational dependence of 13C shielding and coupling constants for methionine methyl groups

31 March 2020

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Ring current effects in the conformation dependent NMR chemical shifts of aliphatic protons in the basic pancreatic trypsin inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Ring current shifts in (19)F-NMR of membrane proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Identification of protein surfaces by NMR measurements with a pramagnetic Gd(III) chelate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Relaxation Effects in Nuclear Magnetic Resonance Absorption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Optical probes based on G protein-coupled receptors - added work or added value?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Multiple ligand-specific conformations of the β2-adrenergic receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

The power of mass spectrometry in structural characterization of GPCR signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

beta-arrestin-biased agonism at the beta2-adrenergic receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Non-analgesic effects of opioids: opioid-induced respiratory depression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Anesthetic potency and influence of morphine and sevoflurane on respiration in mu-opioid receptor knockout mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structural insights into µ-opioid receptor activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Adenosine A2A receptors and basal ganglia physiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure of an agonist-bound human A2A adenosine receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

H(N), N, C(α), C(β) and C' assignments of the intrinsically disordered C-terminus of human adenosine A2A receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structured and disordered facets of the GPCR fold

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

G protein-coupled receptors as targets for anti-diabetic therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Solvent-accessibility of discrete residue positions in the polypeptide hormone glucagon by 19F-NMR observation of 4-fluorophenylalanine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Twenty years on: the impact of fragments on drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Discovering high-affinity ligands for proteins: SAR by NMR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure-based and fragment-based GPCR drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Fragment screening of stabilized G-protein-coupled receptors using biophysical methods

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Fragment screening of GPCRs using biophysical methods: identification of ligands of the adenosine A(2A) receptor with novel biological activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

31 March 2020

NMR in drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A decade of fragment-based drug design: strategic advances and lessons learned

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Improvement of Ligand Affinity and Thermodynamic Properties by NMR-Based Evaluation of Local Dynamics and Surface Complementarity in the Receptor-Bound State

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Conformation of a peptide ligand bound to its G-protein coupled receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structural analysis of CXCR4 - Antagonist interactions using saturation-transfer double-difference NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Determinants of Ligand Subtype-Selectivity at α1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Elucidation of the CCR1- and CCR5-binding modes of MIP-1α by application of an NMR spectra reconstruction method to the transferred cross-saturation experiments

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

NMR analyses of the interaction between CCR5 and its ligand using functional reconstitution of CCR5 in lipid bilayers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure of a GPCR ligand in its receptor-bound state: leukotriene B4 adopts a highly constrained conformation when associated to human BLT2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structural Features for Functional Selectivity at Serotonin Receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A structure-activity analysis of biased agonism at the dopamine D2 receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure and dynamics of the M3 muscarinic acetylcholine receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Competitive association binding kinetic assays: a new tool to detect two different binding orientations of a ligand to its target protein under distinct conditions?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

New Technologies for Elucidating Opioid Receptor Function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

On the relationship between NMR-derived amide order parameters and protein backbone entropy changes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Self-assembly of size-controlled liposomes on DNA nanotemplates.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Applications of dissolution dynamic nuclear polarization in chemistry and biochemistry.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Solution NMR of polypeptides hyperpolarized by dynamic nuclear polarization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Functional and shunt states of bacteriorhodopsin resolved by 250 GHz dynamic nuclear polarization-enhanced solid-state NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Energy transformations early in the bacteriorhodopsin photocycle revealed by DNP-enhanced solid-state NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Primary Transfer Step in the Light-Driven Ion Pump Bacteriorhodopsin: An Irreversible U-Turn Revealed by Dynamic Nuclear Polarization-Enhanced Magic Angle Spinning NMR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Sensitivity-enhanced NMR reveals alterations in protein structure by cellular milieus

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

G-protein-coupled receptor oligomerization and its potential for drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

GPCRs and Signal Transducers: Interaction Stoichiometry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Role of post-translational modifications on structure, function and pharmacology of class C G protein-coupled receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

The expanding repertoire of receptor activity modifying protein (RAMP) function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure of the full-length glucagon class B G-protein-coupled receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Purification of human beta2-adrenergic receptor expressed in methylotrophic yeast Pichia pastoris

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Expression of GPCRs in Pichia pastoris for structural studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure of the human histamine H1 receptor complex with doxepin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

NMR spectroscopy in studies of light-induced structural changes in mammalian rhodopsin: applicability of solution (19)F NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Protein NMR using paramagnetic ions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Theory, practice, and applications of paramagnetic relaxation enhancement for the characterization of transient low-population states of biological macromolecules and their complexes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Practical aspects of (1)H transverse paramagnetic relaxation enhancement measurements on macromolecules.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Paramagnetic labelling of proteins and oligonucleotides for NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Utilization of paramagnetic relaxation enhancements for structural analysis of actin-binding proteins in complex with actin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

TROSY-type Triple-Resonance Experiments for Sequential NMR Assignments of Large Proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

An economic approach to efficient isotope labeling in insect cells using homemade 15N-, 13C- and 2H-labeled yeast extracts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Site-specific in vitro and in vivo incorporation of molecular probes to study G-protein-coupled receptors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Illuminating the Energy Landscape of GPCRs: The Key Contribution of Solution-State NMR Associated with Escherichia coli as an Expression Host.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Expression, purification and preliminary NMR characterization of isotopically labeled wild-type human heterotrimeric G protein αi1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

1H, 13C and 15N backbone chemical shift assignments of camelid single-domain antibodies against active state µ-opioid receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Allosteric regulation of G protein-coupled receptor activity by phospholipids.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Self-Assembly of Discoidal Phospholipid Bilayer Nanoparticles with Membrane Scaffold Proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Nanodiscs in Membrane Biochemistry and Biophysics.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Conformational equilibria of light-activated rhodopsin in nanodiscs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Lipid modulation of early G protein-coupled receptor signalling events.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Calcium-dependent ligand binding and G-protein signaling of family B GPCR parathyroid hormone 1 receptor purified in nanodiscs.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Nanodiscs as a new tool to examine lipid-protein interactions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Covalently circularized nanodiscs for studying membrane proteins and viral entry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

An Adaptable Phospholipid Membrane Mimetic System for Solution NMR Studies of Membrane Proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

A saposin-lipoprotein nanoparticle system for membrane proteins.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Detergent-free formation and physicochemical characterization of nanosized lipid-polymer complexes: Lipodisq

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Functional equilibrium of the KcsA structure revealed by NMR.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Dopamine receptor partial agonists and addiction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Molecular mechanism of 7TM receptor activation--a global toggle switch model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2018.180

Intrinsically disordered proteins in cellular signalling and regulation.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30410121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Production of isotope-labeled proteins in insect cells for NMR.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30410121

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD.2018.180

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30410121%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30410121%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

30410121

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30410121%20AND%20SRC:MED&resulttype=core&format=json