The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor (Q24594844)

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19 January 2020

title

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor (English)

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19 January 2020

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19 January 2020

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19 January 2020

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19 January 2020

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19 January 2020

author name string

Rouslan Moukhametzianov

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19 January 2020

Rony Nehmé

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19 January 2020

Patricia C Edwards

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19 January 2020

Andrew G W Leslie

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19 January 2020

language of work or name

English

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publication date

1 January 2011

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19 January 2020

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19 January 2020

volume

469

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19 January 2020

issue

7329

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19 January 2020

page(s)

241-244

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

19 January 2020

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Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography

24 March 2017

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Crystal structure of opsin in its G-protein-interacting conformation

24 March 2017

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Structure of a beta1-adrenergic G-protein-coupled receptor

24 March 2017

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Crystal structure of the ligand-free G-protein-coupled receptor opsin

24 March 2017

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

24 March 2017

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

24 March 2017

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Features and development of Coot

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Scaling and assessment of data quality

24 March 2017

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The integration of macromolecular diffraction data

24 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

24 March 2017

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24 March 2017

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24 March 2017

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

24 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

24 March 2017

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The structure and function of G-protein-coupled receptors

24 March 2017

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Ligand-directed signalling at beta-adrenoceptors

7 April 2017

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Engineering G protein-coupled receptors to facilitate their structure determination.

27 September 2017

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Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

27 September 2017

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High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

27 September 2017

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Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form

27 September 2017

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27 September 2017

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27 September 2017

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The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

27 September 2017

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Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor

27 September 2017

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Selectivity of dobutamine for adrenergic receptor subtypes: in vitro analysis by radioligand binding

27 September 2017

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27 September 2017

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Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human beta2-adrenoceptor contributes to agonist binding and receptor activation

30 May 2018

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30 May 2018

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30 May 2018

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Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease.

28 November 2018

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Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor

28 November 2018

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The Ile164 beta(2)-adrenoceptor polymorphism alters salmeterol exosite binding and conventional agonist coupling to G(s).

28 November 2018

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Identification of two serine residues involved in agonist activation of the beta-adrenergic receptor

28 November 2018

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12 December 2020

Transferability of thermostabilizing mutations between β-adrenergic receptors

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12 December 2020

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function

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12 December 2020

Identification of a key amino acid of the beta2-adrenergic receptor for high affinity binding of salmeterol

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12 December 2020

The Role of the Seventh Transmembrane Region in High Affinity Binding of a β2-Selective Agonist TA-2005

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE09746

2 references

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Dimensions Publication ID

19 January 2020

1047634683

0 references

1 reference

2 references

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19 January 2020

PubMed publication ID

21228877

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