GPCRs and Signal Transducers: Interaction Stoichiometry (Q88607655)

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26 March 2020

title

GPCRs and Signal Transducers: Interaction Stoichiometry (English)

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26 March 2020

Vsevolod V Gurevich

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26 March 2020

Eugenia V Gurevich

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26 March 2020

language of work or name

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5 May 2018

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Trends in Pharmacological Sciences

26 March 2020

published in

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26 March 2020

volume

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26 March 2020

issue

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26 March 2020

page(s)

672-684

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Responses of retinal rods to single photons

26 March 2020

cites work

1 reference

12 December 2020

Mechanism of rhodopsin kinase activation

1 reference

12 December 2020

Light activation of one rhodopsin molecule causes the phosphorylation of hundreds of others. A reaction observed in electropermeabilized frog rod outer segments exposed to dim illumination

1 reference

12 December 2020

Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin

1 reference

12 December 2020

Duration and amplitude of the light-induced cGMP hydrolysis in vertebrate photoreceptors are regulated by multiple phosphorylation of rhodopsin and by arrestin binding

1 reference

12 December 2020

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

1 reference

12 December 2020

Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin.

1 reference

12 December 2020

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

1 reference

12 December 2020

The 2.0 A crystal structure of a heterotrimeric G protein

1 reference

12 December 2020

Phosphorylation of non-bleached rhodopsin in intact retinas and living frogs

1 reference

12 December 2020

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

1 reference

12 December 2020

Mechanism of quenching of phototransduction. Binding competition between arrestin and transducin for phosphorhodopsin.

1 reference

12 December 2020

Dimerization of the delta opioid receptor: implication for a role in receptor internalization

1 reference

12 December 2020

G-protein-coupled receptors: turn-ons and turn-offs

1 reference

12 December 2020

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1 reference

12 December 2020

The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation

1 reference

12 December 2020

G-protein-coupled receptor heterodimerization modulates receptor function

1 reference

12 December 2020

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

12 December 2020

Mapping the agonist-binding site of GABAB type 1 subunit sheds light on the activation process of GABAB receptors

1 reference

12 December 2020

Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

1 reference

12 December 2020

Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice

1 reference

12 December 2020

Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation

1 reference

12 December 2020

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

1 reference

12 December 2020

Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta-arrestin-dependent interactions between neurokinin receptors

1 reference

12 December 2020

The nature of the arrestin x receptor complex determines the ultimate fate of the internalized receptor

1 reference

12 December 2020

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

1 reference

12 December 2020

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

1 reference

12 December 2020

Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein

1 reference

12 December 2020

Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors

1 reference

12 December 2020

Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns

1 reference

12 December 2020

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

1 reference

12 December 2020

Different functional roles of T1R subunits in the heteromeric taste receptors

1 reference

12 December 2020

Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers

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12 December 2020

Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors

1 reference

12 December 2020

Trafficking of adenosine A2A and dopamine D2 receptors

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12 December 2020

D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor

1 reference

12 December 2020

Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions

1 reference

12 December 2020

Monomeric G-protein-coupled receptor as a functional unit

1 reference

12 December 2020

Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells

1 reference

12 December 2020

Crystal structure of cone arrestin at 2.3A: evolution of receptor specificity.

1 reference

12 December 2020

Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex

1 reference

12 December 2020

Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin

1 reference

12 December 2020

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells

1 reference

12 December 2020

Functional and structural characterization of rhodopsin oligomers

1 reference

12 December 2020

Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin

1 reference

12 December 2020

Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors

1 reference

12 December 2020

The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

1 reference

12 December 2020

Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding.

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12 December 2020

Arrestin interaction with rhodopsin: conceptual models.

1 reference

12 December 2020

G protein-coupled receptor dimerisation: molecular basis and relevance to function

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12 December 2020

D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

1 reference

12 December 2020

Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors

1 reference

12 December 2020

Structure and function of the visual arrestin oligomer

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12 December 2020

Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity.

1 reference

12 December 2020

Each rhodopsin molecule binds its own arrestin

1 reference

12 December 2020

Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins

1 reference

12 December 2020

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

1 reference

12 December 2020

Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction

1 reference

12 December 2020

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

1 reference

12 December 2020

Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer

1 reference

12 December 2020

GPCR monomers and oligomers: it takes all kinds

1 reference

12 December 2020

Binding of orthosteric ligands to the allosteric site of the M(2) muscarinic cholinergic receptor

1 reference

12 December 2020

Activation of calcium/calmodulin-dependent protein kinase IIalpha in the striatum by the heteromeric D1-D2 dopamine receptor complex

1 reference

12 December 2020

Formation and dissociation of M1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

1 reference

12 December 2020

Monomeric rhodopsin is the minimal functional unit required for arrestin binding

1 reference

12 December 2020

Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2

1 reference

12 December 2020

The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia

1 reference

12 December 2020

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding

1 reference

12 December 2020

Arrestin-1 expression level in rods: balancing functional performance and photoreceptor health

1 reference

12 December 2020

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

1 reference

12 December 2020

Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation.

1 reference

12 December 2020

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

1 reference

12 December 2020

Robust self-association is a common feature of mammalian visual arrestin-1.

1 reference

12 December 2020

Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging

1 reference

12 December 2020

The oligomeric state sets GABA(B) receptor signalling efficacy

1 reference

12 December 2020

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

12 December 2020

The functional cycle of visual arrestins in photoreceptor cells

1 reference

12 December 2020

G protein-coupled receptor kinases: more than just kinases and not only for GPCRs

1 reference

12 December 2020

Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids

1 reference

12 December 2020

Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

1 reference

12 December 2020

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

1 reference

12 December 2020

Evidence for the existence of dopamine D2-oxytocin receptor heteromers in the ventral and dorsal striatum with facilitatory receptor-receptor interactions.

1 reference

12 December 2020

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function

1 reference

12 December 2020

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

1 reference

12 December 2020

Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance

1 reference

12 December 2020

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding

1 reference

12 December 2020

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function

1 reference

12 December 2020

CrossTalk proposal: Weighing the evidence for Class A GPCR dimers, the evidence favours dimers

1 reference

12 December 2020

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

1 reference

12 December 2020

Rebuttal from Michel Bouvier and Terence E. Hébert

1 reference

12 December 2020

Rebuttal from Nevin A. Lambert and Jonathan A. Javitch

1 reference

12 December 2020

Coupling of g proteins to reconstituted monomers and tetramers of the M2 muscarinic receptor

1 reference

12 December 2020

Visualization of arrestin recruitment by a G-protein-coupled receptor

1 reference

12 December 2020

Evidence against dopamine D1/D2 receptor heteromers

1 reference

12 December 2020

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling

1 reference

12 December 2020

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).

1 reference

12 December 2020

Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases

1 reference

12 December 2020

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor

1 reference

12 December 2020

Arrestins: Critical Players in Trafficking of Many GPCRs

1 reference

12 December 2020

G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro

1 reference

12 December 2020

G Protein-Coupled Receptor Multimers: A Question Still Open Despite the Use of Novel Approaches

1 reference

12 December 2020

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

1 reference

12 December 2020

G Protein-Coupled Receptor Heteromers.

1 reference

12 December 2020

Allosteric modulation in monomers and oligomers of a G protein-coupled receptor

1 reference

12 December 2020

Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

1 reference

12 December 2020

In Vivo Significance of In Vitro Studies on G-Protein-Coupled Receptor Heteromers

1 reference

12 December 2020

Structure of the adenosine A(2A) receptor bound to an engineered G protein.

1 reference

12 December 2020

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

1 reference

12 December 2020

Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

1 reference

12 December 2020

Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors

1 reference

12 December 2020

Functional competence of a partially engaged GPCR-β-arrestin complex

1 reference

12 December 2020

Organization and functions of mGlu and GABAB receptor complexes

1 reference

12 December 2020

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis

1 reference

12 December 2020

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation.

1 reference

12 December 2020

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

1 reference

12 December 2020

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

1 reference

12 December 2020

Molecular assembly of rhodopsin with G protein-coupled receptor kinases.

1 reference

12 December 2020

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

1 reference

12 December 2020

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells

1 reference

12 December 2020

Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.

1 reference

12 December 2020

The Class-A GPCR Dopamine D2 Receptor Forms Transient Dimers Stabilized by Agonists: Detection by Single-Molecule Tracking

1 reference

12 December 2020

Heterologous phosphorylation-induced formation of a stability lock permits regulation of inactive receptors by β-arrestins

1 reference

12 December 2020

Lack of beta-arrestin signaling in the absence of active G proteins.

1 reference

12 December 2020

Cloning, expression, purification and characterization of oligomeric states of the native 5HT2A G-Protein-Coupled Receptor

1 reference

12 December 2020

10.1016/J.TIPS.2018.04.002

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29739625%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

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26 March 2020

PubMed publication ID

29739625

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