Structure-based discovery of opioid analgesics with reduced side effects (Q26331003)

27 June 2017

title

Structure-based discovery of opioid analgesics with reduced side effects (English)

1 reference

27 June 2017

0 references

Brian K Kobilka

1 reference

27 June 2017

Aashish Manglik

1 reference

27 June 2017

Viachaslau Bernat

0 references

Grégory Scherrer

0 references

Peter Gmeiner

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Brian K Shoichet

1 reference

27 June 2017

Henry Lin

1 reference

27 June 2017

Daniela Dengler

1 reference

27 June 2017

Gregory Corder

1 reference

27 June 2017

Anat Levit

1 reference

27 June 2017

Harald Hübner

1 reference

27 June 2017

Xi-Ping Huang

1 reference

27 June 2017

Stefan Löber

1 reference

27 June 2017

Da Duan

1 reference

27 June 2017

Dipendra K Aryal

1 reference

27 June 2017

John D McCorvy

1 reference

27 June 2017

Ralf C Kling

1 reference

27 June 2017

Maria F Sassano

1 reference

27 June 2017

Patrick M Giguère

1 reference

27 June 2017

Bryan L Roth

1 reference

27 June 2017

language of work or name

English

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publication date

17 August 2016

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27 June 2017

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27 June 2017

volume

537

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27 June 2017

issue

7619

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27 June 2017

page(s)

185-190

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Elucidating an Affective Pain Circuit that Creates a Threat Memory

27 June 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structural basis for bifunctional peptide recognition at human δ-opioid receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Covalent agonists for studying G protein-coupled receptor activation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure of the δ-opioid receptor bound to naltrindole

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure of the human κ-opioid receptor in complex with JDTic

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Comparison of multiple Amber force fields and development of improved protein backbone parameters

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure-based discovery of a novel, noncovalent inhibitor of AmpC beta-lactamase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Functionally selective dopamine D₂, D₃ receptor partial agonists

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

ChEMBL: a large-scale bioactivity database for drug discovery

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Automated docking screens: a feasibility study

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Enhanced morphine analgesia in mice lacking beta-arrestin 2

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

7 April 2017

https://api.crossref.org/works/10.1038%2FNATURE19112

inferred from DOI database lookup

7 January 2021

based on heuristic

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Development and testing of a general amber force field

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

ZINC: a free tool to discover chemistry for biology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structural insights into µ-opioid receptor activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Mu opioids and their receptors: evolution of a concept

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Discovery of a novel selective kappa-opioid receptor agonist using crystal structure-based virtual screening

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Thermal sensitivity as a measure of spontaneous morphine withdrawal in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Automated design of ligands to polypharmacological profiles.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Ligand discovery from a dopamine D3 receptor homology model and crystal structure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Quantifying ligand bias at seven-transmembrane receptors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure-based discovery of A2A adenosine receptor ligands

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Chronic social stress and susceptibility to concentrated ambient fine particles in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Structure-based discovery of beta2-adrenergic receptor ligands

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Application of belief theory to similarity data fusion for use in analog searching and lead hopping

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

G protein coupling and ligand selectivity of the D2L and D3 dopamine receptors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Animal models of nociception.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

The catalepsy test: its ups and downs

28 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

28 September 2017

https://api.crossref.org/works/10.1038%2FNATURE19112

The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: Correlation of nociceptive behavior and c-fos expression

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Identification of two related pentapeptides from the brain with potent opiate agonist activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Endogenous opioid peptides: multiple agonists and receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Mu Opioid Receptor Modulation of Dopamine Neurons in the Periaqueductal Gray/Dorsal Raphe: A Role in Regulation of Pain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Identification of novel adenosine A(2A) receptor antagonists by virtual screening.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Acute tolerance in morphine analgesia: continuous infusion and single injection in rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Morphine side effects in beta-arrestin 2 knockout mice

31 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Rapid context-dependent ligand desolvation in molecular docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Quantifying biased agonism: understanding the links between affinity and efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Olfactory exposure to males, including men, causes stress and related analgesia in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Species-specific defense reactions and avoidance learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Some quantitative properties of anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

The missing term in effective pair potentials

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Molecular Dynamics Simulations of the Effect of the G-Protein and Diffusible Ligands on the β2-Adrenergic Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19112

Discriminative conditioning; effects of a Pavlovian conditioned stimulus upon a subsequently established operant response.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

INHIBITION OF AVOIDANCE BEHAVIOR.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

Passive and active reactions to fear-eliciting stimuli

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5161585

The formalin test in mice: dissociation between inflammatory and non-inflammatory pain

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27533032

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE19112

1 reference

journals/nature/ManglikLAMDCLKB16

27 June 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

1003034403

0 references

OpenCitations bibliographic resource ID

4524819

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4524819

PMC publication ID

5161585

0 references

1 reference