Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic (Q27679151)

Raymond C Stevens

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Eyal Vardy

Eyal Vardy

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Girolamo Calò

Girolamo Calo

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Wei Liu

Wei Liu

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author name string

Aaron A Thompson

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Eugene Chun

Structure of the human κ-opioid receptor in complex with JDTic

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language of work or name

English

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publication date

16 May 2012

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published in

Nature

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volume

485

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issue

7398

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page(s)

395-9

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cites work

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Structural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)

20 March 2017

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ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

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Functional inactivation of the nociceptin receptor by alanine substitution of glutamine 286 at the C terminus of transmembrane segment VI: evidence from a site-directed mutagenesis study of the ORL1 receptor transmembrane-binding domain

20 March 2017

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The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

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Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes

7 April 2017

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Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity

29 September 2017

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The nociceptin pharmacophore site for opioid receptor binding derived from the NMR structure and bioactivity relationships.

29 September 2017

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Identification of a hexapeptide binding region in the nociceptin (ORL1) receptor by photo-affinity labelling with Ac-Arg-Bpa-Tyr-Arg-Trp-Arg-NH2

29 September 2017

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[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

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Specific receptor for the opioid peptide dynorphin: structure--activity relationships

29 September 2017

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The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

29 September 2017

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2 June 2018

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Moving from the orphanin FQ receptor to an opioid receptor using four point mutations

2 June 2018

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Structure-activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide.

2 June 2018

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Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

27 November 2018

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The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).

27 November 2018

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Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes

27 November 2018

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A robotic system for crystallizing membrane and soluble proteins in lipidic mesophases

27 November 2018

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Creating a functional opioid alkaloid binding site in the orphanin FQ receptor through site-directed mutagenesis.

27 November 2018

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Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

27 November 2018

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Further Studies on Nociceptin-Related Peptides: Discovery of a New Chemical Template with Antagonist Activity on the Nociceptin Receptor

27 November 2018

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12 December 2020

Dopamine–nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: Involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Comparison of the structure-activity relationships of nociceptin and dynorphin A using chimeric peptides

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12 December 2020

Molecular modelling of the ORL1 receptor and its complex with nociceptin

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12 December 2020

Identifiers

DOI

10.1038/NATURE11085

1 reference

Dimensions Publication ID

1026270837

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1 reference

1 reference

PubMed publication ID

22596163

1 reference