Visualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme B (Q27312334)

April 2022 Public Data File from Crossref

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Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

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The structural basis for membrane binding and pore formation by lymphocyte perforin

21 March 2017

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Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse.

21 March 2017

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Cathepsin H is an additional convertase of pro-granzyme B

21 March 2017

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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

21 March 2017

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Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

21 March 2017

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Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

21 March 2017

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Serglycin--structure and biology

21 March 2017

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The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis

21 March 2017

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

21 March 2017

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Serine protease inhibitor 6 is required to protect dendritic cells from the kiss of death

21 March 2017

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Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers

28 September 2017

1 reference

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ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

28 September 2017

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The structure and function of mammalian membrane-attack complex/perforin-like proteins.

28 September 2017

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Visualizing early splenic memory CD8+ T cells reactivation against intracellular bacteria in the mouse

28 September 2017

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Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules

28 September 2017

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The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

28 September 2017

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Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses

28 September 2017

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Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation

28 September 2017

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Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

28 September 2017

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Death by a thousand cuts: granzyme pathways of programmed cell death

28 September 2017

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Protein kinase Cdelta regulates antigen receptor-induced lytic granule polarization in mouse CD8+ CTL

28 September 2017

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Secretory mechanisms in cell-mediated cytotoxicity

28 September 2017

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Delivering the kiss of death: progress on understanding how perforin works

28 September 2017

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Regulating secretory lysosomes

28 September 2017

1 reference

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Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.

28 September 2017

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Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate

28 September 2017

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Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

28 September 2017

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Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

28 September 2017

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An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

28 September 2017

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Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression

28 September 2017

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Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

28 September 2017

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Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo

28 September 2017

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Rapid modification of bacterial artificial chromosomes by ET-recombination.

28 September 2017

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Long-range disruption of gene expression by a selectable marker cassette

28 September 2017

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Lysosome-associated membrane proteins h-LAMP1 (CD107a) and h-LAMP2 (CD107b) are activation-dependent cell surface glycoproteins in human peripheral blood mononuclear cells which mediate cell adhesion to vascular endothelium

28 September 2017

1 reference

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Immune function in mice lacking the perforin gene

28 September 2017

1 reference

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Mechanism of lymphocyte-mediated cytotoxicity

28 September 2017

1 reference

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Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695958

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14.

28 September 2017

1 reference

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CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

28 September 2017

1 reference

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Molecular mechanisms of cytolysis by complement and by cytolytic lymphocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695958

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695958

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695958

Acquisition of murine NK cell cytotoxicity requires the translation of a pre-existing pool of granzyme B and perforin mRNAs.

31 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

A central role for Bid in granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Papillon-Lefèvre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Dipeptidyl peptidase I: importance of progranzyme activation sequences, other dipeptide sequences, and the N-terminal amino group of synthetic substrates for enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Centrosome polarization delivers secretory granules to the immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

The immunological synapse of CTL contains a secretory domain and membrane bridges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

T cell killing does not require the formation of a stable mature immunological synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0067239

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3695958

Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice

28 November 2018

1 reference

12 December 2020

A family of serine esterases in lytic granules of cytolytic T lymphocytes

1 reference

12 December 2020

T-cell activation is accompanied by an ubiquitination process occurring at the immunological synapse

1 reference

12 December 2020

Activation of the ancestral polarity regulator protein kinase C zeta at the immunological synapse drives polarization of Th cell secretory machinery toward APCs

1 reference

12 December 2020

Granzyme B-tdTomato, a new probe to visualize cytolytic effector cell activation

1 reference

12 December 2020