Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate (Q40352632)

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scientific article published on 9 November 2005

Language	Label	Description	Also known as
English	Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate	scientific article published on 9 November 2005

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate (English)

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

author name string

Kirstin Veugelers

1

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Bruce Motyka

2

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Ing Swie Goping

3

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Irene Shostak

4

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Tracy Sawchuk

5

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

R Chris Bleackley

6

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

publication date

9 November 2005

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Molecular Biology of the Cell

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

17

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

2

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

623-633

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Membrane receptors are not required to deliver granzyme B during killer cell attack

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Intracellular proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Granzyme B: pro-apoptotic, antiviral and antitumor functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Granzyme B: a natural born killer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Mitochondria at the heart of the cytotoxic attack

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Functional significance of the perforin/granzyme cell death pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Cytotoxic T lymphocytes: all roads lead to death

1 reference

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22 September 2017

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Lymphocyte-mediated cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1356574

22 September 2017

Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo

1 reference

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22 September 2017

In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

1 reference

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22 September 2017

The interaction of the transforming growth factor-betas with heparin/heparan sulfate is isoform-specific.

1 reference

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22 September 2017

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

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22 September 2017

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

1 reference

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22 September 2017

Sulfated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity

1 reference

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22 September 2017

Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product

1 reference

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22 September 2017

Identification and characterization of cells deficient in the mannose 6-phosphate receptor: evidence for an alternate pathway for lysosomal enzyme targeting

1 reference

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22 September 2017

Morphologic study of the internalization of a lysosomal enzyme by the mannose 6-phosphate receptor in cultured Chinese hamster ovary cells

1 reference

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22 September 2017

Mechanism of membrane damage by streptolysin-O.

1 reference

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22 September 2017

The overexpressed human 46-kDa mannose 6-phosphate receptor mediates endocytosis and sorting of beta-glucuronidase

1 reference

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22 September 2017

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

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22 September 2017

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

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22 September 2017

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

1 reference

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25 September 2017

Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent

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Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

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VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates for efficient binding to the VEGF receptors of human melanoma cells

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Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

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Involvement of an ICE-like protease in Fas-mediated apoptosis

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Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity

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Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

1 reference

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Unimpaired allorejection of cells deficient for the mannose 6-phosphate receptors Mpr300 and Mpr46.

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Electrostatic reversal of serine proteinase substrate specificity

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A rapid sensitive silver stain for polypeptides in polyacrylamide gels

1 reference

https://pubmed.ncbi.nlm.nih.gov/16280358

12 December 2020

based on heuristic

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Inhibition of the lytic activity of perforin (cytolysin) and of late complement components by proteoglycans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16280358

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Rapid purification of cationic granule proteases: application to human granzymes

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https://pubmed.ncbi.nlm.nih.gov/16280358

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based on heuristic

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Fractionation of perforin and granzymes by immobilized metal affinity chromatography (IMAC)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16280358

12 December 2020

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New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16280358

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Identifiers

10.1091/MBC.E05-07-0631

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 September 2017

ResearchGate publication ID

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