Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation (Q39862902)

15 September 2017

Visualizing CTL/melanoma cell interactions: multiple hits must be delivered for tumour cell annihilation (English)

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15 September 2017

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Iris Caramalho

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15 September 2017

Mustapha Faroudi

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15 September 2017

Elisabetta Padovan

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15 September 2017

Sabina Müller

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15 September 2017

Salvatore Valitutti

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15 September 2017

6 October 2008

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Journal of Cellular and Molecular Medicine

15 September 2017

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15 September 2017

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15 September 2017

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15 September 2017

3834-3846

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describes a project that uses

15 September 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4516531/fullTextXML

inferred from PubMed Central ID database lookup

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Suppression of proximal T cell receptor signaling and lytic function in CD8+ tumor-infiltrating T cells

22 September 2017

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Mobilizing the low-avidity T cell repertoire to kill tumors

22 September 2017

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22 September 2017

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The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

22 September 2017

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The human T cell response to melanoma antigens

22 September 2017

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Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation

22 September 2017

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Cytotoxic T lymphocytes kill multiple targets simultaneously via spatiotemporal uncoupling of lytic and stimulatory synapses.

22 September 2017

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The decreased susceptibility of metastatic melanoma cells to killing involves an alteration of CTL reactivity.

22 September 2017

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Defective adhesion in tumor infiltrating CD8+ T cells.

22 September 2017

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Human T cell responses against melanoma

22 September 2017

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Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure

22 September 2017

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Regulatory T cells in immune surveillance and treatment of cancer.

22 September 2017

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Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

22 September 2017

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Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

22 September 2017

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Cancer immunoediting: from immunosurveillance to tumor escape

22 September 2017

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Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation

22 September 2017

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Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

22 September 2017

1 reference

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IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity

22 September 2017

1 reference

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Cancer-induced defective cytotoxic T lymphocyte effector function: another mechanism how antigenic tumors escape immune-mediated killing

22 September 2017

1 reference

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HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story

22 September 2017

1 reference

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Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes

22 September 2017

1 reference

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Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions

22 September 2017

1 reference

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Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography

22 September 2017

1 reference

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Impaired binding of perforin on the surface of tumor cells is a cause of target cell resistance against cytotoxic effector cells.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516531

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516531

Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516531

Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts.

25 September 2017

1 reference

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Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516531

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

20 August 2018

1 reference

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T cell killing does not require the formation of a stable mature immunological synapse.

20 August 2018

1 reference

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

20 August 2018

1 reference

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Cleavage of Bcl-2 in oxidant- and cisplatin-induced apoptosis of human melanoma cells

20 August 2018

1 reference

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Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy.

20 August 2018

1 reference

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Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells

20 August 2018

1 reference

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Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

20 August 2018

1 reference

12 December 2020

CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

1 reference

12 December 2020

IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells

1 reference

12 December 2020

Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape

1 reference

12 December 2020

Immune cells in the tumor microenvironment. Mechanisms responsible for functional and signaling defects

1 reference

12 December 2020

Tumor-specific cytolysis by lymphocytes infiltrating human melanomas

1 reference

12 December 2020

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

1 reference

12 December 2020

10.1111/J.1582-4934.2008.00586.X

Identifiers

DOI

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15 September 2017

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15 September 2017

PubMed publication ID

19017355

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