Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules (Q37773158)

22 August 2017

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title

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules (English)

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Geneviève de Saint Basile

22 August 2017

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Alain Fischer

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series ordinal

object named as

Geneviève de Saint Basile

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author name string

Gaël Ménasché

series ordinal

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22 August 2017

publication date

16 July 2010

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Nature Reviews Immunology

22 August 2017

published in

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

568-579

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Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.

22 August 2017

cites work

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Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes.

21 January 2018

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Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

21 January 2018

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Snares and Munc18 in synaptic vesicle fusion

21 January 2018

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Munc18-1 in secretion: lonely Munc joins SNARE team and takes control.

21 January 2018

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Expression and function of synaptotagmin VII in CTLs

21 January 2018

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Cross-presentation in viral immunity and self-tolerance.

21 January 2018

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Formation and function of the lytic NK-cell immunological synapse

31 March 2020

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The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity

31 March 2020

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Cell-death signaling and human disease

31 March 2020

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The role of cytotoxicity in lymphocyte homeostasis.

31 March 2020

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Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis

31 March 2020

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Perforin-mediated suppression of B-cell lymphoma

31 March 2020

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Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

31 March 2020

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The immunological synapse: a molecular machine controlling T cell activation

31 March 2020

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

31 March 2020

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Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

31 March 2020

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T cell killing does not require the formation of a stable mature immunological synapse.

31 March 2020

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Perforin-mediated target-cell death and immune homeostasis

31 March 2020

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31 March 2020

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The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments

31 March 2020

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Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

31 March 2020

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31 March 2020

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The endocytic pathway: a mosaic of domains

31 March 2020

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The emerging shape of the ESCRT machinery

31 March 2020

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Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

31 March 2020

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ESCRT complexes and the biogenesis of multivesicular bodies

31 March 2020

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Secretory Lysosome Biogenesis in Cytotoxic T Lymphocytes from Normal and Chediak Higashi Syndrome Patients

31 March 2020

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The major human and mouse granzymes are structurally and functionally divergent

31 March 2020

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Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death

31 March 2020

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The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation

31 March 2020

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Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

31 March 2020

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Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

31 March 2020

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The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness

31 March 2020

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Adaptor protein 3-dependent microtubule-mediated movement of lytic granules to the immunological synapse

31 March 2020

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Analysis of the lysosomal storage disease Chediak-Higashi syndrome

31 March 2020

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Hermansky-Pudlak syndrome and related disorders of organelle formation

31 March 2020

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Molecular genetics of the Hermansky-Pudlak and Chediak-Higashi syndromes

31 March 2020

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Hermansky-Pudlak syndrome: vesicle formation from yeast to man.

31 March 2020

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Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome

31 March 2020

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Identification of the homologous beige and Chediak-Higashi syndrome genes

31 March 2020

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Mechanisms of membrane fusion: disparate players and common principles.

31 March 2020

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Neurobeachin is essential for neuromuscular synaptic transmission.

31 March 2020

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The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins

31 March 2020

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Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly

31 March 2020

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Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome

31 March 2020

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A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family.

31 March 2020

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Progressive neurologic dysfunctions 20 years after allogeneic bone marrow transplantation for Chediak-Higashi syndrome.

31 March 2020

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Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II

31 March 2020

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AP-3: an adaptor-like protein complex with ubiquitous expression

31 March 2020

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EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin

31 March 2020

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Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

31 March 2020

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A common fold mediates vertebrate defense and bacterial attack

31 March 2020

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The molecular basis for perforin oligomerization and transmembrane pore assembly

31 March 2020

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Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain.

31 March 2020

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Apoptosis induced by the lymphocyte effector molecule perforin

31 March 2020

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Mechanisms of granule-dependent killing

31 March 2020

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Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

31 March 2020

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Human and mouse granzyme A induce a proinflammatory cytokine response.

31 March 2020

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Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

31 March 2020

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In Vitro– and Ex Vivo–derived Cytolytic Leukocytes from Granzyme A × B Double Knockout Mice Are Defective in Granule-mediated Apoptosis but not Lysis of Target Cells

31 March 2020

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Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

31 March 2020

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Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

31 March 2020

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Centrosome polarization delivers secretory granules to the immunological synapse.

31 March 2020

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Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain

31 March 2020

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The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse

31 March 2020

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T cell receptor signaling precedes immunological synapse formation

31 March 2020

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A role for phosphatidylinositol 3-kinase in TCR-stimulated ERK activation leading to paxillin phosphorylation and CTL degranulation

31 March 2020

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

31 March 2020

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Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

31 March 2020

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The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

31 March 2020

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Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170

31 March 2020

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Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse.

31 March 2020

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Distinct roles for the actin nucleators Arp2/3 and hDia1 during NK-mediated cytotoxicity.

31 March 2020

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Rab27a: A key to melanosome transport in human melanocytes

31 March 2020

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Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome

31 March 2020

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A mutation in Rab27a causes the vesicle transport defects observed in ashen mice

31 March 2020

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Evolution of the Rab family of small GTP-binding proteins

31 March 2020

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Rab27a is required for regulated secretion in cytotoxic T lymphocytes

31 March 2020

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Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice

31 March 2020

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A newly identified isoform of Slp2a associates with Rab27a in cytotoxic T cells and participates to cytotoxic granule secretion

31 March 2020

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Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse

31 March 2020

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Identification of an organelle receptor for myosin-Va

31 March 2020

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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

31 March 2020

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Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis

31 March 2020

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Secretory cytotoxic granule maturation and exocytosis require the effector protein hMunc13-4

31 March 2020

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Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity

31 March 2020

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Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy

31 March 2020

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SNAREpins: minimal machinery for membrane fusion

31 March 2020

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SNAREs--engines for membrane fusion

31 March 2020

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Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11

31 March 2020

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Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

31 March 2020

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Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin

31 March 2020

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A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.

31 March 2020

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Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

31 March 2020

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Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells.

31 March 2020

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Vesicle trafficking: pleasure and pain from SM genes.

31 March 2020

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Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes

31 March 2020

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Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses

31 March 2020

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Temporal and spatial coordination of exocytosis and endocytosis.

31 March 2020

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The synaptic vesicle cycle

31 March 2020

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Molecular organization of the presynaptic active zone

31 March 2020

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Munc18-1: sequential interactions with the fusion machinery stimulate vesicle docking and priming.

31 March 2020

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Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

31 March 2020

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Selective activation of cognate SNAREpins by Sec1/Munc18 proteins

31 March 2020

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Membrane fusion: grappling with SNARE and SM proteins

31 March 2020

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Cytotoxic T lymphocyte exocytosis: bring on the SNAREs!

31 March 2020

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A role for endobrevin/VAMP8 in CTL lytic granule exocytosis

31 March 2020

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Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

31 March 2020

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Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps

31 March 2020

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Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1)

31 March 2020

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12 December 2020

A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic

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12 December 2020

Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network

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12 December 2020

Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis

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12 December 2020

Identifiers

DOI

10.1038/NRI2803

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22 August 2017

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