Current and Future Challenges in GPCR Drug Discovery (Q47348761)

14 January 2018

title

Current and Future Challenges in GPCR Drug Discovery (English)

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14 January 2018

G protein-coupled receptor

main subject

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Sid Topiol

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14 January 2018

language of work or name

English

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publication date

1 January 2018

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14 January 2018

Methods in Molecular Biology

published in

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14 January 2018

volume

1705

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14 January 2018

page(s)

1-21

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14 January 2018

Images of purple membrane at 2.8 A resolution obtained by cryo-electron microscopy

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)

21 January 2018

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21 January 2018

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Structure-based discovery of opioid analgesics with reduced side effects

21 January 2018

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Highly Selective Dopamine D3 Receptor (D3R) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment.

21 January 2018

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Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HT6 receptor ligands with significant selectivity for D3 over D2 receptors

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

21 January 2018

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Design, synthesis and biological evaluation of (E)-3,4-dihydroxystyryl 4-acylaminophenethyl sulfone, sulfoxide derivatives as dual inhibitors of HIV-1 CCR5 and integrase

21 January 2018

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21 January 2018

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Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength

21 January 2018

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Rational design of partial agonists for the muscarinic m1 acetylcholine receptor

21 January 2018

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Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.

21 January 2018

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Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure

21 January 2018

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10.1007/978-1-4939-7465-8_1

21 January 2018

Identifiers

DOI

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14 January 2018

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14 January 2018