Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs (Q46674963)

From Wikidata

Jump to navigation Jump to search

scientific article published on 22 September 2015

Language	Label	Description	Also known as
English	Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs	scientific article published on 22 September 2015

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

author name string

Christopher R Behrens

1

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Edward H Ha

2

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Lawrence L Chinn

3

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Simeon Bowers

4

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Gary Probst

5

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Maureen Fitch-Bruhns

6

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Jorge Monteon

7

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Amanda Valdiosera

8

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Abel Bermudez

9

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Sindy Liao-Chan

10

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Tiffany Wong

11

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Jonathan Melnick

12

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Jan-Willem Theunissen

13

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Mark R Flory

14

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Derrick Houser

15

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Kristy Venstrom

16

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Zoia Levashova

17

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Paul Sauer

18

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Thi-Sau Migone

19

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Edward H van der Horst

20

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Randall L Halcomb

21

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

David Y Jackson

22

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

language of work or name

0 references

publication date

22 September 2015

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Molecular Pharmaceutics

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

12

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

11

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

3986-3998

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arming antibodies for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel peptide linkers for highly potent antibody-auristatin conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analytical methods for physicochemical characterization of antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturing antibody-drug conjugate pipeline hits 30.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugate (ADC) clinical pipeline: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates: present and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general approach to site-specific antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bridging disulfides for stable and defined antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods to Make Homogenous Antibody Drug Conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of an anti-CD98 antibody.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab-MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.MOLPHARMACEUT.5B00432

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46674963&oldid=2125824643"