A general approach to site-specific antibody drug conjugates (Q37571113)

21 August 2017

A general approach to site-specific antibody drug conjugates (English)

1 reference

21 August 2017

1 reference

Peter G Schultz

1 reference

21 August 2017

Feng Tian

1 reference

21 August 2017

Yingchun Lu

1 reference

21 August 2017

Anthony Manibusan

1 reference

21 August 2017

Aaron Sellers

1 reference

21 August 2017

Hon Tran

1 reference

21 August 2017

Ying Sun

1 reference

21 August 2017

Trung Phuong

1 reference

21 August 2017

Richard Barnett

1 reference

21 August 2017

Brad Hehli

1 reference

21 August 2017

Frank Song

1 reference

21 August 2017

Michael J DeGuzman

1 reference

21 August 2017

Semsi Ensari

1 reference

21 August 2017

Jason K Pinkstaff

1 reference

21 August 2017

Lorraine M Sullivan

1 reference

21 August 2017

Sandra L Biroc

1 reference

21 August 2017

Ho Cho

1 reference

21 August 2017

John DiJoseph

1 reference

21 August 2017

Maureen Dougher

1 reference

21 August 2017

Dangshe Ma

1 reference

21 August 2017

Russell Dushin

1 reference

21 August 2017

Mauricio Leal

1 reference

21 August 2017

Lioudmila Tchistiakova

1 reference

21 August 2017

Eric Feyfant

1 reference

21 August 2017

Hans-Peter Gerber

1 reference

21 August 2017

Puja Sapra

1 reference

21 August 2017

language of work or name

English

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publication date

17 January 2014

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Proceedings of the National Academy of Sciences of the United States of America

21 August 2017

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21 August 2017

111

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21 August 2017

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21 August 2017

1766-1771

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Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Site-specific protein modifications through pyrroline-carboxy-lysine residues

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Optimized clinical performance of growth hormone with an expanded genetic code

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Delineation of a Cellular Hierarchy in Lung Cancer Reveals an Oncofetal Antigen Expressed on Tumor-Initiating Cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Cu-free click cycloaddition reactions in chemical biology

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Antibody-drug conjugates for cancer therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Adding amino acids to the genetic repertoire

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Arming antibodies: prospects and challenges for immunoconjugates

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Arming antibodies for cancer therapy

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Complete set of orthogonal 21st aminoacyl-tRNA synthetase-amber, ochre and opal suppressor tRNA pairs: concomitant suppression of three different termination codons in an mRNA in mammalian cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Production of recombinant protein therapeutics in cultivated mammalian cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

An expanded eukaryotic genetic code

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Eradication of large colon tumor xenografts by targeted delivery of maytansinoids

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Investigational antibody drug conjugates for solid tumors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Contribution of linker stability to the activities of anticancer immunoconjugates

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3918752

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24443552

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24443552

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24443552

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1321237111

1 reference

21 August 2017

0 references

1 reference

21 August 2017

PubMed publication ID

24443552

1 reference