Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes (Q34434128)

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English	Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 August 2017

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes (English)

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Europe PubMed Central

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2 August 2017

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David Rabuka

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2 August 2017

author name string

Penelope M Drake

1

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2 August 2017

Aaron E Albers

2

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2 August 2017

Jeanne Baker

3

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2 August 2017

Stefanie Banas

4

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2 August 2017

Robyn M Barfield

5

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2 August 2017

Abhijit S Bhat

6

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2 August 2017

Gregory W de Hart

7

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2 August 2017

Albert W Garofalo

8

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2 August 2017

Patrick Holder

9

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2 August 2017

Lesley C Jones

10

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2 August 2017

Romas Kudirka

11

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2 August 2017

Jesse McFarland

12

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Wes Zmolek

13

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publication date

23 June 2014

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2 August 2017

Bioconjugate Chemistry

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2 August 2017

25

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7

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2 August 2017

1331-1341

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2 August 2017

In vitro and in vivo evaluation of cysteine and site specific conjugated herceptin antibody-drug conjugates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

A general approach to site-specific antibody drug conjugates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Site-specific antibody drug conjugates for cancer therapy

1 reference

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1 reference

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6 July 2018

Maturing antibody-drug conjugate pipeline hits 30.

1 reference

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6 July 2018

Antibody-drug conjugates in cancer therapy

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6 July 2018

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

1 reference

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6 July 2018

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Clinical pharmacology of trastuzumab emtansine (T-DM1): an antibody-drug conjugate in development for the treatment of HER2-positive cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer

1 reference

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6 July 2018

Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer

1 reference

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6 July 2018

Prediction of immunogenicity of therapeutic proteins: validity of computational tools

1 reference

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6 July 2018

Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

New approaches to prediction of immune responses to therapeutic proteins during preclinical development

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Function and Structure of a Prokaryotic Formylglycine-generating Enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

FcRn: the neonatal Fc receptor comes of age.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Introducing genetically encoded aldehydes into proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

Identification and removal of immunogenicity in therapeutic proteins.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215875

6 July 2018

A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake

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6 July 2018

The development of a modified human IFN-alpha2b linked to the Fc portion of human IgG1 as a novel potential therapeutic for the treatment of hepatitis C virus infection

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6 July 2018

Phase I study of anticolon cancer humanized antibody A33.

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6 July 2018

Crystal structures of human antibodies: a detailed and unfinished tapestry of immunoglobulin gene products

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SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

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Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates

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27 October 2018

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats

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Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII.

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Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33

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12 December 2020

based on heuristic

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Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

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12 December 2020

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Monoclonal Antibodies with Identical Fc Sequences Can Bind to FcRn Differentially with Pharmacokinetic Consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/24924618

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/24924618

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BC500189Z

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Europe PubMed Central

PubMed publication ID

2 August 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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