Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. (Q39959127)

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11 January 2020

title

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index (English)

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11 January 2020

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publication date

20 July 2008

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volume

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issue

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11 January 2020

page(s)

925-932

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Monoclonal antibody therapy of cancer

11 January 2020

cites work

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7 January 2021

Upping the ante on antibodies

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7 January 2021

Arming antibodies for cancer therapy

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7 January 2021

Arming antibodies: prospects and challenges for immunoconjugates

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7 January 2021

Drug-conjugated monoclonal antibodies for the treatment of cancer

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7 January 2021

Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models

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7 January 2021

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

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7 January 2021

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

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7 January 2021

A prostate-specific membrane antigen-targeted monoclonal antibody-chemotherapeutic conjugate designed for the treatment of prostate cancer

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7 January 2021

Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen

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7 January 2021

The development of antibody delivery systems to target cancer with highly potent maytansinoids

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7 January 2021

Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides

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7 January 2021

In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine against CD56+ multiple myeloma cells

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7 January 2021

Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study

1 reference

7 January 2021

Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity

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7 January 2021

Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen

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7 January 2021

CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma

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7 January 2021

Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry

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7 January 2021

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

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7 January 2021

Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity

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7 January 2021

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

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7 January 2021

Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance

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7 January 2021

Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment

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7 January 2021

One disulfide bond in front of the second heavy chain constant region is necessary and sufficient for effector functions of human IgG3 without a genetic hinge

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7 January 2021

Conversion of incomplete antibodies to direct agglutinins by mild reduction: evidence for segmental flexibility within the Fc fragment of immunoglobulin G

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7 January 2021

Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond

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7 January 2021

Site-specific attachment to recombinant antibodies via introduced surface cysteine residues

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7 January 2021

Site-specific conjugation on serine right-arrow cysteine variant monoclonal antibodies

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7 January 2021

Therapeutic antibody fragments with prolonged in vivo half-lives

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7 January 2021

Structural effect of a recombinant monoclonal antibody on hinge region peptide bond hydrolysis

1 reference

7 January 2021