Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index (Q38863927)

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scientific article published on 15 June 2015

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Language	Label	Description	Also known as
English	Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index	scientific article published on 15 June 2015

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instance of

scholarly article

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stated in

Europe PubMed Central

PubMed publication ID

26076429

retrieved

7 September 2017

title

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index (English)

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

main subject

hydrophobicity

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inferred from title

antibody

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inferred from title

pharmacokinetics

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author name string

Robert P Lyon

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1

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

Tim D Bovee

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2

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

Svetlana O Doronina

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3

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

Patrick J Burke

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4

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

Joshua H Hunter

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26076429

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7 September 2017

Haley D Neff-LaFord

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6

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26076429

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7 September 2017

Mechthild Jonas

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PubMed publication ID

26076429

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7 September 2017

Martha E Anderson

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8

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Europe PubMed Central

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26076429

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Jocelyn R Setter

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9

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

Peter D Senter

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10

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

language of work or name

English

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publication date

15 June 2015

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Europe PubMed Central

PubMed publication ID

26076429

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7 September 2017

published in

Nature Biotechnology

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26076429

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7 September 2017

volume

33

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26076429

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7 September 2017

issue

7

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26076429

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7 September 2017

page(s)

733-735

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26076429

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7 September 2017

cites work

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Phase I biodistribution and pharmacokinetic study of Lewis Y-targeting immunoconjugate CMD-193 in patients with advanced epithelial cancers

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Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues

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Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry

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Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

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A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology

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Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains

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Antibody conjugates of 7-ethyl-10-hydroxycamptothecin (SN-38) for targeted cancer chemotherapy

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Development and properties of beta-glucuronide linkers for monoclonal antibody-drug conjugates

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Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker

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Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity

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The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease

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retrieved

12 December 2020

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Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26076429

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26076429

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12 December 2020

based on heuristic

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Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/26076429

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NBT.3212

1 reference

stated in

Europe PubMed Central

PubMed publication ID

26076429

retrieved

7 September 2017

PubMed publication ID

26076429

1 reference

stated in

Europe PubMed Central

PubMed publication ID

26076429

retrieved

7 September 2017

 

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