Methods to Make Homogenous Antibody Drug Conjugates (Q35523479)

8 August 2017

6 references

19 September 2019

27 September 2019

27 November 2019

13 December 2019

18 September 2020

16 July 2021

Methods to Make Homogenous Antibody Drug Conjugates (English)

1 reference

biomedical investigative technique

8 August 2017

main subject

1 reference

19 September 2019

1 reference

27 September 2019

1 reference

27 November 2019

1 reference

13 December 2019

small molecule libraries

0 references

pharmaceutical science

1 reference

16 July 2021

Toni Kline

1 reference

8 August 2017

Alexander R Steiner

1 reference

8 August 2017

Kalyani Penta

1 reference

8 August 2017

Aaron K Sato

1 reference

8 August 2017

Trevor J Hallam

1 reference

8 August 2017

Gang Yin

1 reference

8 August 2017

publication date

16 December 2014

1 reference

8 August 2017

1 November 2015

6 references

19 September 2019

27 September 2019

27 November 2019

13 December 2019

18 September 2020

16 July 2021

Pharmaceutical Research

6 references

8 August 2017

19 September 2019

27 September 2019

27 November 2019

13 December 2019

16 July 2021

1 reference

8 August 2017

1 reference

8 August 2017

page(s)

3480-3493

1 reference

Creative Commons Attribution 4.0 International

8 August 2017

1 reference

Site-specific antibody-drug conjugation through an engineered glycotransferase and a chemically reactive sugar

16 July 2021

copyrighted

0 references

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Unnatural amino acids in novel antibody conjugates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Preparation of well-defined antibody-drug conjugates through glycan remodeling and strain-promoted azide-alkyne cycloadditions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Bridging disulfides for stable and defined antibody drug conjugates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Chemoenzymatic Fc glycosylation via engineered aldehyde tags.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Antibody-drug conjugates: an emerging concept in cancer therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific antibody-drug conjugation through glycoengineering.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Engineering toward a bacterial "endoplasmic reticulum" for the rapid expression of immunoglobulin proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific antibody drug conjugates for cancer therapy

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Antibody-drug conjugates: current status and future directions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Enzymatic labeling of proteins: techniques and approaches

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

New functional handle for use as a self-reporting contrast and delivery agent in nanomedicine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Cell-free translation of peptides and proteins: from high throughput screening to clinical production

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Imaging trans-cellular neurexin-neuroligin interactions by enzymatic probe ligation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Small targeted cytotoxics: current state and promises from DNA-encoded chemical libraries

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Streamlined expressed protein ligation using split inteins.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Antibody-drug conjugates for the treatment of cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

A Pictet-Spengler ligation for protein chemical modification

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Local unfolding is required for the site-specific protein modification by transglutaminase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific chemical protein conjugation using genetically encoded aldehyde tags

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific protein modification using lipoic acid ligase and bis-aryl hydrazone formation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Diels-Alder cycloaddition for fluorophore targeting to specific proteins inside living cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by Sortase A-mediated protein ligation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Brentuximab Vedotin (SGN-35).

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Copper-free Sonogashira cross-coupling for functionalization of alkyne-encoded proteins in aqueous medium and in bacterial cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific modification of ED-B-targeting antibody using intein-fusion technology

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

A general strategy for the evolution of bond-forming enzymes using yeast display

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Microscale to manufacturing scale‐up of cell‐free cytokine production—a new approach for shortening protein production development timelines

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific and stoichiometric modification of antibodies by bacterial transglutaminase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Olefin cross-metathesis on proteins: investigation of allylic chalcogen effects and guiding principles in metathesis partner selection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

A fluorophore ligase for site-specific protein labeling inside living cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Synthesis of an acyltrifluoroborate and its fusion with azides to form amides

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Adding new chemistries to the genetic code

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Molecularly defined antibody conjugation through a selenocysteine interface

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Sortase-mediated ligation: a gift from Gram-positive bacteria to protein engineering.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

A pyrrolysine analogue for protein click chemistry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Targeted cancer therapy: conferring specificity to cytotoxic drugs

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Cell killing by antibody-drug conjugates

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

In vitro selection of RNA aptamer against Escherichia coli release factor 1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Pyrrolysine analogues as substrates for pyrrolysyl-tRNA synthetase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Antibody targeted drugs as cancer therapeutics

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Site-specific labeling of cell surface proteins with biophysical probes using biotin ligase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Properties and applications of microbial transglutaminase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Pyrrolysine encoded by UAG in Archaea: charging of a UAG-decoding specialized tRNA.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Methods for site-specific drug conjugation to antibodies

27 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Genetic incorporation of unnatural amino acids into proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Adding l-lysine derivatives to the genetic code of mammalian cells with engineered pyrrolysyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Multiple-site labeling of proteins with unnatural amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Efficient suppression of the amber codon in E. coli in vitro translation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Cell-free translation reconstituted with purified components

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Translation initiation with initiator tRNA charged with exotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

N-terminal protein modification by substrate-activated reverse proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Site-specific protein labeling with amine-containing molecules using Lactobacillus plantarum sortase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Enzymatic antibody tagging: toward a universal biocompatible targeting tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Selenocysteine in native chemical ligation and expressed protein ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Ligand-free palladium-mediated site-specific protein labeling inside gram-negative bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Allyl sulfides are privileged substrates in aqueous cross-metathesis: application to site-selective protein modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Olefin metathesis for chemical biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Rapid cross-metathesis for reversible protein modifications via chemical access to Se-allyl-selenocysteine in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

Efficient N-terminal labeling of proteins by use of sortase.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

In vivo, site-specific, covalent conjugation of quantum dots to proteins via split-intein splicing.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4596908

Protein Engineering by In Vivo Incorporation of Non-Natural Amino Acids: Control of Incorporation of Methionine Analogues by Methionyl-tRNA Synthetase

26 September 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-014-1596-8

A flexizyme that selectively charges amino acids activated by a water-friendly leaving group

21 January 2018

1 reference

12 December 2020

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

1 reference

12 December 2020

Rapid ligations with equimolar reactants in water with the potassium acyltrifluoroborate (KAT) amide formation

1 reference

12 December 2020

Comparative evaluation of two cell-free protein synthesis systems derived from Escherichia coli for genetic code reprogramming

1 reference

12 December 2020

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

1 reference

12 December 2020

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

12 December 2020

Ligation of expressed protein α-hydrazides via genetic incorporation of an α-hydroxy acid

1 reference

12 December 2020

In vitro Sortagging of an Antibody Fab Fragment: Overcoming Unproductive Reactions of Sortase with Water and Lysine Side Chains

1 reference

12 December 2020

Palladium-mediated site-selective Suzuki–Miyaura protein modification at genetically encoded aryl halides

1 reference

12 December 2020

10.1007/S11095-014-1596-8

Identifiers

DOI

1 reference

release_6ma6mw65uffqzauix3zjpvvmlq

8 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6ma6mw65uffqzauix3zjpvvmlq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

4596908

1 reference

8 August 2017

1 reference