Poliovirus receptor-related 2

NECTIN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3R0N, 4DFH, 4DFI, 4HZA
Identifiers
Aliases	NECTIN2, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2
External IDs	OMIM: 600798; MGI: 97822; HomoloGene: 86092; GeneCards: NECTIN2; OMA:NECTIN2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,889,223 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,484,408 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; olfactory zone of nasal mucosa; ; apex of heart; ; right lobe of liver; ; gallbladder; ; right testis; ; left adrenal cortex; ; body of stomach; ; mucosa of transverse colon; ; upper lobe of left lung;
	Top expressed in
	yolk sac; ; transitional epithelium of urinary bladder; ; Ileal epithelium; ; decidua; ; gastrula; ; lumbar spinal ganglion; ; endothelial cell of lymphatic vessel; ; duodenum; ; epiblast; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; virus receptor activity; protein binding; identical protein binding; signaling receptor binding; cell adhesion molecule binding; protein heterodimerization activity; protein homodimerization activity;
Cellular component	integral component of membrane; membrane; cell-cell junction; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; zonula adherens; extracellular exosome; apical junction complex; cell-cell contact zone;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; sperm mitochondrion organization; cell recognition; positive regulation of immunoglobulin mediated immune response; regulation of viral entry into host cell; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of mast cell activation; cell adhesion; acrosome assembly; cytoskeleton organization; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; cilium organization; establishment of mitochondrion localization; spermatid development; regulation of immune response; fertilization; spermatid nucleus differentiation; susceptibility to T cell mediated cytotoxicity; viral process; cell part morphogenesis; adherens junction organization; positive regulation of natural killer cell mediated cytotoxicity; homophilic cell adhesion via plasma membrane adhesion molecules; viral entry into host cell; signal transduction; positive regulation of T cell receptor signaling pathway; virion attachment to host cell;
	Sources:Amigo / QuickGO
Orthologs
	5819
	19294
	ENSG00000130202
	ENSMUSG00000062300
	Q92692
	P32507
	NM_001042724; NM_002856
	NM_001159724; NM_008990
	NP_001036189; NP_002847
	NP_001153196; NP_033016
	Wikidata
View/Edit Human	View/Edit Mouse

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.^[5]

Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130202 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062300 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)".

Eberlé F, Dubreuil P, Mattei MG, et al. (1995). "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene". Gene. 159 (2): 267–72. doi:10.1016/0378-1119(95)00180-E. PMID 7622062.
Warner MS, Geraghty RJ, Martinez WM, et al. (1998). "A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus". Virology. 246 (1): 179–89. doi:10.1006/viro.1998.9218. PMID 9657005.
Freistadt MS, Eberle KE (1998). "Physical association between CD155 and CD44 in human monocytes". Mol. Immunol. 34 (18): 1247–57. doi:10.1016/S0161-5890(98)00003-0. PMID 9683266.
Lopez M, Aoubala M, Jordier F, et al. (1999). "The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule". Blood. 92 (12): 4602–11. doi:10.1182/blood.V92.12.4602. PMID 9845526.
Shukla D, Rowe CL, Dong Y, et al. (1999). "The Murine Homolog (Mph) of Human Herpesvirus Entry Protein B (HveB) Mediates Entry of Pseudorabies Virus but Not Herpes Simplex Virus Types 1 and 2". J. Virol. 73 (5): 4493–7. doi:10.1128/JVI.73.5.4493-4497.1999. PMC 104343. PMID 10196354.
Takahashi K, Nakanishi H, Miyahara M, et al. (1999). "Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein". J. Cell Biol. 145 (3): 539–49. doi:10.1083/jcb.145.3.539. PMC 2185068. PMID 10225955.
Freitas EM, Zhang WJ, Lalonde JP, et al. (1999). "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1". DNA Seq. 9 (2): 89–100. doi:10.3109/10425179809086433. PMID 10520737.
Lopez M, Cocchi F, Menotti L, et al. (2000). "Nectin2α (PRR2α or HveB) and Nectin2δ Are Low-Efficiency Mediators for Entry of Herpes Simplex Virus Mutants Carrying the Leu25Pro Substitution in Glycoprotein D". J. Virol. 74 (3): 1267–74. doi:10.1128/JVI.74.3.1267-1274.2000. PMC 111461. PMID 10627537.
Cocchi F, Menotti L, Dubreuil P, et al. (2000). "Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)". J. Virol. 74 (8): 3909–17. doi:10.1128/JVI.74.8.3909-3917.2000. PMC 111902. PMID 10729168.
Bouchard MJ, Dong Y, McDermott BM, et al. (2000). "Defects in Nuclear and Cytoskeletal Morphology and Mitochondrial Localization in Spermatozoa of Mice Lacking Nectin-2, a Component of Cell-Cell Adherens Junctions". Mol. Cell. Biol. 20 (8): 2865–73. doi:10.1128/MCB.20.8.2865-2873.2000. PMC 85510. PMID 10733589.
Martinez WM, Spear PG (2001). "Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry". J. Virol. 75 (22): 11185–95. doi:10.1128/JVI.75.22.11185-11195.2001. PMC 114698. PMID 11602758.
Freitas EM, Phan TC, Herbison CE, et al. (2002). "The poliovirus receptor related 2 (PRR2) and apolipoprotein E genes and coronary heart disease". Journal of Cardiovascular Risk. 9 (1): 59–65. doi:10.1097/00043798-200202000-00009. PMID 11984219.
Fabre S, Reymond N, Cocchi F, et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057.
Struyf F, Martinez WM, Spear PG (2002). "Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions". J. Virol. 76 (24): 12940–50. doi:10.1128/JVI.76.24.12940-12950.2002. PMC 136698. PMID 12438620.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bottino C, Castriconi R, Pende D, et al. (2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as Cell Surface Ligands for the Human DNAM-1 (CD226) Activating Molecule". J. Exp. Med. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
Zago A, Spear PG (2003). "Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells". J. Virol. 77 (17): 9695–9. doi:10.1128/JVI.77.17.9695-9699.2003. PMC 187405. PMID 12915581.
Tahara-Hanaoka S, Shibuya K, Onoda Y, et al. (2005). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". Int. Immunol. 16 (4): 533–8. doi:10.1093/intimm/dxh059. hdl:2241/102014. PMID 15039383.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Rosche B, Cepok S, Stei S, et al. (2004). "The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS". J. Neuroimmunol. 156 (1–2): 171–7. doi:10.1016/j.jneuroim.2004.07.001. PMID 15465608. S2CID 39448365.

External links

PVRL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q92692 (Human Nectin-2) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: P32507 (Mouse Nectin-2) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130202 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062300 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)".

[1]

[2]

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[5]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Poliovirus receptor-related 2

Function

See also

References

Further reading

External links