CDH10

CDH10
Identifiers
Aliases	CDH10, cadherin 10
External IDs	OMIM: 604555; MGI: 107436; HomoloGene: 68530; GeneCards: CDH10; OMA:CDH10 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	24,644,978 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	19,014,322 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; middle temporal gyrus; ; Brodmann area 46; ; orbitofrontal cortex; ; superior frontal gyrus; ; cerebellar hemisphere; ; entorhinal cortex; ; right hemisphere of cerebellum; ; prefrontal cortex; ; dorsolateral prefrontal cortex;
	Top expressed in
	Subplate; ; barrel cortex; ; prefrontal cortex; ; Region I of hippocampus proper; ; facial motor nucleus; ; ventral tegmental area; ; anterior horn of spinal cord; ; primary motor cortex; ; dorsal tegmental nucleus; ; deep cerebellar nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; metal ion binding; cytoskeletal protein binding; protein homodimerization activity; cadherin binding;
Cellular component	integral component of membrane; plasma membrane; membrane; glutamatergic synapse; GABA-ergic synapse; integral component of presynaptic active zone membrane; integral component of postsynaptic specialization membrane; cell surface; catenin complex;
Biological process	cell adhesion; adherens junction organization; homophilic cell adhesion via plasma membrane adhesion molecules; cell-cell adhesion; cell-cell junction assembly; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; cell morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1008
	320873
	ENSG00000040731
	ENSMUSG00000022321
	Q9Y6N8
	P70408
	NM_001190450; NM_006727; NM_001317222; NM_001317224; NM_001362460
	NM_009865; NM_001316758
	NP_001304151; NP_001304153; NP_006718; NP_001349389; NP_001304153.1
	NP_001303687; NP_033995
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin 10 is a protein that in humans is encoded by the CDH10 gene.^[5]^[6]

Clinical significance

An association with autism has been suggested.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000040731 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022321 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: cadherin 10".
^ Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
^ Wang K, Zhang H, Ma D, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.

External links

Human CDH10 genome location and CDH10 gene details page in the UCSC Genome Browser.

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2000). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
Wang K, Zhang H, Ma D, et al. (2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.
Potkin SG, Guffanti G, Lakatos A, et al. (2009). "Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease". PLOS ONE. 4 (8): e6501. Bibcode:2009PLoSO...4.6501P. doi:10.1371/journal.pone.0006501. PMC 2719581. PMID 19668339.
Gil OD, Needleman L, Huntley GW (2002). "Developmental patterns of cadherin expression and localization in relation to compartmentalized thalamocortical terminations in rat barrel cortex". J. Comp. Neurol. 453 (4): 372–88. doi:10.1002/cne.10424. PMID 12389209. S2CID 25610258.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kools P, Vanhalst K, Van den Eynde E, van Roy F (1999). "The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14". FEBS Lett. 452 (3): 328–34. doi:10.1016/S0014-5793(99)00672-9. PMID 10386616. S2CID 44714251.
Hillier LD, Lennon G, Becker M, et al. (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Ali J, Liao F, Martens E, Muller WA (1997). "Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion". Microcirculation. 4 (2): 267–77. doi:10.3109/10739689709146790. PMID 9219219. S2CID 21501093.
Ma D, Salyakina D, Jaworski JM, et al. (2009). "A genome-wide association study of autism reveals a common novel risk locus at 5p14.1". Ann. Hum. Genet. 73 (Pt 3): 263–73. doi:10.1111/j.1469-1809.2009.00523.x. PMC 2918410. PMID 19456320.
Hülsken J, Birchmeier W, Behrens J (1994). "E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton". J. Cell Biol. 127 (6 Pt 2): 2061–9. doi:10.1083/jcb.127.6.2061. PMC 2120290. PMID 7806582.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000040731 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022321 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: cadherin 10".

[pmid2059658-6] Suzuki S, Sano K, Tanihara H (April 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.

[pmid19404256-7] Wang K, Zhang H, Ma D, et al. (May 2009). "Common genetic variants on 5p14.1 associate with autism spectrum disorders". Nature. 459 (7246): 528–33. Bibcode:2009Natur.459..528W. doi:10.1038/nature07999. PMC 2943511. PMID 19404256.

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CDH10

Clinical significance

See also

References

External links

Further reading