LAMP3

LAMP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AKM
Identifiers
Aliases	LAMP3, CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403, lysosomal-associated membrane protein 3, lysosomal associated membrane protein 3
External IDs	OMIM: 605883; MGI: 2441659; HomoloGene: 8670; GeneCards: LAMP3; OMA:LAMP3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	183,163,839 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	19,525,125 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; sperm; ; visceral pleura; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; upper lobe of lung; ; appendix; ; upper lobe of left lung; ; hair follicle; ; gingival epithelium;
	Top expressed in
	lung; ; blastocyst; ; lens; ; neural layer of retina; ; spleen; ; spermatid; ; heart;
	More reference expression data
	More reference expression data
Orthologs
	27074
	239739
	ENSG00000078081
	ENSMUSG00000041247
	Q9UQV4
	Q7TST5
	NM_014398
	NM_177356
	NP_055213
	NP_796330
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosome-associated membrane glycoprotein 3 (LAMP3, Lamp3) is a protein that in humans is encoded by the LAMP3 gene.^[5]^[6] It is one of the lysosome-associated membrane glycoproteins.

LAMP3 also known as DC-LAMP (Dendritic cell lysosomal associated membrane glycoprotein) is a member of the LAMP family along with LAMP1 and LAMP2, these proteins make up the members of the glycoconjugate coat present on the inside of the lysosomal membrane.^[7] In humans, this protein is almost exclusively found in mature Dendritic cells. While LAMP3 can be observed on the surface of dendritic cells, the protein is mainly found within lysosomes. LAMP3 first appears in the MHC Class II compartment and in cells aids in the identifying and processing of an antigen during an immune response.^[8]^[9] LAMP3 protein is linked with the maturation of dendritic cells, and as a marker for transformed type II pneumocytes or alveolar cells.^[10]

Studies have linked LAMP3 with the inhibition of the viral replication of Influenza A cells.^[11]

Structure and Tissue Distribution

LAMP3 is a Type I integral membrane protein consisting of about 416 amino acid residues with about 90% of the protein located within the lumen of the lysosomes.^[9] LAMP3 has been shown to be highly expressed in dendritic cells during cell differentiation and maturation.^[7] During human fetal development, between weeks 10 and 20, LAMP3 is highly expressed in the lungs, while in normal adult tissue cells LAMP3 is expressed in the lungs, appendix, testis and lymph nodes.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078081 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041247 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, Takahashi E, Nakamura Y (Sep 1998). "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues". Cancer Res. 58 (16): 3499–503. PMID 9721848.
^ "Entrez Gene: LAMP3 lysosomal-associated membrane protein 3".
^ ^a ^b Malaguarnera L, Marsullo A, Zorena K, Musumeci G, Di Rosa M (2017). "Vitamin D3 regulates LAMP3 expression in monocyte derived dendritic cells". Cell Immunol. 311: 13–21. doi:10.1016/j.cellimm.2016.09.013. PMID 27697285.
^ "ThermoFisher".
^ ^a ^b "CD208 (DC-LAMP)". BeckmanCoulter.
^ Salaun B, de Saint-Vis B, Pacheco N, Pacheco Y, Riesler A, Isaac S, Leroux C, Clair-Moninot V, Pin JJ, Griffith J, Treilleux I, Goddard S, Davoust J, Kleijmeer M, Lebecque S (2004). "CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes". Am J Pathol. 164 (3): 861–71. doi:10.1016/S0002-9440(10)63174-4. PMC 1613301. PMID 14982840.
^ Zhou Z, Xue Q, Wan Y, Yang Y, Wang J, Hung T (2011). "Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells". Virology Journal. 8: 384. doi:10.1186/1743-422X-8-384. PMC 3162545. PMID 21810281.
^ "LAMP3 lysosomal associated membrane protein 3 [ Homo sapiens (human) ]".

External links

Overview of all the structural information available in the PDB for UniProt: Q9UQV4 (Human Lysosome-associated membrane glycoprotein 3 (LAMP3)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078081 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041247 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9721848-5] Ozaki K, Nagata M, Suzuki M, Fujiwara T, Ueda K, Miyoshi Y, Takahashi E, Nakamura Y (Sep 1998). "Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues". Cancer Res. 58 (16): 3499–503. PMID 9721848.

[entrez-6] "Entrez Gene: LAMP3 lysosomal-associated membrane protein 3".

[:0-7] Malaguarnera L, Marsullo A, Zorena K, Musumeci G, Di Rosa M (2017). "Vitamin D3 regulates LAMP3 expression in monocyte derived dendritic cells". Cell Immunol. 311: 13–21. doi:10.1016/j.cellimm.2016.09.013. PMID 27697285.

[8] "ThermoFisher".

[:1-9] "CD208 (DC-LAMP)". BeckmanCoulter.

[10] Salaun B, de Saint-Vis B, Pacheco N, Pacheco Y, Riesler A, Isaac S, Leroux C, Clair-Moninot V, Pin JJ, Griffith J, Treilleux I, Goddard S, Davoust J, Kleijmeer M, Lebecque S (2004). "CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes". Am J Pathol. 164 (3): 861–71. doi:10.1016/S0002-9440(10)63174-4. PMC 1613301. PMID 14982840.

[11] Zhou Z, Xue Q, Wan Y, Yang Y, Wang J, Hung T (2011). "Lysosome-associated membrane glycoprotein 3 is involved in influenza A virus replication in human lung epithelial (A549) cells". Virology Journal. 8: 384. doi:10.1186/1743-422X-8-384. PMC 3162545. PMID 21810281.

[12] "LAMP3 lysosomal associated membrane protein 3 [ Homo sapiens (human) ]".

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

v t e Peroxisomal and lysosomal proteins
Enzymes	Mevalonate kinase Catalase Acetyl-CoA C-acyltransferase Glyceronephosphate O-acyltransferase Alkylglycerone phosphate synthase Phytanoyl-CoA dioxygenase HSD17B4 AMACR
Transporters	SLC27A2
Structure/Peroxin	PEX1 PXMP3 PEX3 PEX5 PEX6 PEX7 PEX10 PEX11A PEX11B PEX11G PEX12 PEX13 PEX14 PEX16 PEX19 PEX26
LAMP	CD68 LAMP1 LAMP2 LAMP3
see also intermediates, disorders

Structure and Tissue Distribution

References

Further reading

External links