GP1BB

GP1BB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3REZ, 3RFE
Identifiers
Aliases	GP1BB, BDPLT1, BS, CD42C, GPIBB, GPIbbeta, glycoprotein Ib platelet beta subunit, glycoprotein Ib platelet subunit beta
External IDs	OMIM: 138720; MGI: 107852; HomoloGene: 30972; GeneCards: GP1BB; OMA:GP1BB - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	19,724,771 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	18,441,153 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; primary visual cortex; ; gonad; ; olfactory zone of nasal mucosa; ; bone marrow cells; ; spleen; ; superior frontal gyrus; ; sural nerve;
	Top expressed in
	ileum; ; spleen; ; jejunum; ; bone marrow; ; ganglionic eminence; ; neural tube; ; mesencephalon; ; striatum of neuraxis; ; vasculature; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; transmembrane signaling receptor activity; identical protein binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	platelet activation; blood coagulation, intrinsic pathway; hemostasis; cell surface receptor signaling pathway; cell adhesion; blood coagulation;
	Sources:Amigo / QuickGO
Orthologs
	2812
	14724
	ENSG00000203618
	ENSMUSG00000050761
	P13224
	P56400
	NM_000407
	NM_001001999; NM_010327
	NP_000398
	NP_001001999; NP_034457
	Wikidata
View/Edit Human	View/Edit Mouse

Glycoprotein Ib (platelet), beta polypeptide (GP1BB) also known as CD42c (Cluster of Differentiation 42c), is a protein that in humans is encoded by the GP1BB gene.^[5]

Function

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the Glycoprotein Ib-IX-V Receptor Complex (GPIb-V-IX) system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard–Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal within a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its own imperfect site, the septin 5 gene uses the consensus polyA signal of this gene.^[5]

Interactions

GP1BB has been shown to interact with YWHAZ.^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000203618 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: GP1BB glycoprotein Ib (platelet), beta polypeptide".
^ Calverley DC, Kavanagh TJ, Roth GJ (February 1998). "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood. 91 (4): 1295–303. doi:10.1182/blood.V91.4.1295. PMID 9454760.
^ Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC (July 1994). "Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex". J. Biol. Chem. 269 (28): 18287–90. doi:10.1016/S0021-9258(17)32301-3. PMID 8034572.
^ Feng S, Christodoulides N, Reséndiz JC, Berndt MC, Kroll MH (January 2000). "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V". Blood. 95 (2): 551–7. doi:10.1182/blood.V95.2.551. PMID 10627461. S2CID 77799615.

Kunishima S, Kamiya T, Saito H (2002). "Genetic abnormalities of Bernard-Soulier syndrome". Int. J. Hematol. 76 (4): 319–27. doi:10.1007/BF02982690. PMID 12463594. S2CID 23635810.
Clemetson KJ (2007). "A short history of platelet glycoprotein Ib complex". Thromb. Haemost. 98 (1): 63–8. doi:10.1160/th07-05-0327. PMID 17597992.
Wardell MR, Reynolds CC, Berndt MC, Wallace RW, Fox JE (1989). "Platelet glycoprotein Ib beta is phosphorylated on serine 166 by cyclic AMP-dependent protein kinase". J. Biol. Chem. 264 (26): 15656–61. doi:10.1016/S0021-9258(19)84882-2. PMID 2504723.
Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (1989). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complex". Biochemistry. 28 (21): 8317–26. doi:10.1021/bi00447a009. PMID 2557900.
Berndt MC, Gregory C, Kabral A, Zola H, Fournier D, Castaldi PA (1985). "Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane". Eur. J. Biochem. 151 (3): 637–49. doi:10.1111/j.1432-1033.1985.tb09152.x. PMID 3161731.
Lopez JA, Chung DW, Fujikawa K, Hagen FS, Davie EW, Roth GJ (1988). "The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 85 (7): 2135–9. Bibcode:1988PNAS...85.2135L. doi:10.1073/pnas.85.7.2135. PMC 279943. PMID 3353370.
Canfield VA, Ozols J, Nugent D, Roth GJ (1987). "Isolation and characterization of the alpha and beta chains of human platelet glycoprotein Ib". Biochem. Biophys. Res. Commun. 147 (2): 526–34. doi:10.1016/0006-291X(87)90963-6. PMID 3632685.
Hickey MJ, Hagen FS, Yagi M, Roth GJ (1993). "Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteins". Proc. Natl. Acad. Sci. U.S.A. 90 (18): 8327–31. Bibcode:1993PNAS...90.8327H. doi:10.1073/pnas.90.18.8327. PMC 47349. PMID 7690959.
Meyer SC, Fox JE (1995). "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von Willebrand factor to glycoprotein Ib-IX in transfected cells". J. Biol. Chem. 270 (24): 14693–9. doi:10.1074/jbc.270.24.14693. PMID 7782333.
Yagi M, Edelhoff S, Disteche CM, Roth GJ (1994). "Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta". J. Biol. Chem. 269 (26): 17424–7. doi:10.1016/S0021-9258(17)32456-0. PMID 8021244.
Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC (1994). "Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex". J. Biol. Chem. 269 (28): 18287–90. doi:10.1016/S0021-9258(17)32301-3. PMID 8034572.
Kelly MD, Essex DW, Shapiro SS, Meloni FJ, Druck T, Huebner K, Konkle BA (1994). "Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22". J. Clin. Invest. 93 (6): 2417–24. doi:10.1172/JCI117249. PMC 294449. PMID 8200976.
Ludlow LB, Schick BP, Budarf ML, Driscoll DA, Zackai EH, Cohen A, Konkle BA (1996). "Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibbeta promoter resulting in the Bernard-Soulier syndrome". J. Biol. Chem. 271 (36): 22076–80. doi:10.1074/jbc.271.36.22076. PMID 8703016.
Zieger B, Hashimoto Y, Ware J (1997). "Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence". J. Clin. Invest. 99 (3): 520–5. doi:10.1172/JCI119188. PMC 507827. PMID 9022087.
Kunishima S, Lopez JA, Kobayashi S, Imai N, Kamiya T, Saito H, Naoe T (1997). "Missense mutations of the glycoprotein (GP) Ib beta gene impairing the GPIb alpha/beta disulfide linkage in a family with giant platelet disorder". Blood. 89 (7): 2404–12. doi:10.1182/blood.V89.7.2404. PMID 9116284.
Andrews RK, Harris SJ, McNally T, Berndt MC (1998). "Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex". Biochemistry. 37 (2): 638–47. doi:10.1021/bi970893g. PMID 9425086.
Longhurst CM, White MM, Wilkinson DA, Jennings LK (1999). "A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem. 263 (1): 104–11. doi:10.1046/j.1432-1327.1999.00467.x. PMID 10429193.
Feng S, Christodoulides N, Reséndiz JC, Berndt MC, Kroll MH (2000). "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V". Blood. 95 (2): 551–7. doi:10.1182/blood.V95.2.551. PMID 10627461. S2CID 77799615.
Moran N, Morateck PA, Deering A, Ryan M, Montgomery RR, Fitzgerald DJ, Kenny D (2000). "Surface expression of glycoprotein ib alpha is dependent on glycoprotein ib beta: evidence from a novel mutation causing Bernard-Soulier syndrome". Blood. 96 (2): 532–9. doi:10.1182/blood.V96.2.532. PMID 10887115.
Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ (2002). "Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3". J. Biol. Chem. 277 (14): 11949–56. doi:10.1074/jbc.M108727200. PMID 11812775.

External links

GP1BB+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
PDBe-KB provides an overview of all the structure information available in the PDB for Human Platelet glycoprotein Ib beta chain (GP1BB)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000203618 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GP1BB glycoprotein Ib (platelet), beta polypeptide".

[pmid9454760-6] Calverley DC, Kavanagh TJ, Roth GJ (February 1998). "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta". Blood. 91 (4): 1295–303. doi:10.1182/blood.V91.4.1295. PMID 9454760.

[pmid8034572-7] Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC (July 1994). "Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex". J. Biol. Chem. 269 (28): 18287–90. doi:10.1016/S0021-9258(17)32301-3. PMID 8034572.

[pmid10627461-8] Feng S, Christodoulides N, Reséndiz JC, Berndt MC, Kroll MH (January 2000). "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V". Blood. 95 (2): 551–7. doi:10.1182/blood.V95.2.551. PMID 10627461. S2CID 77799615.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

GP1BB

Function

Interactions

See also

References

Further reading

External links