Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders. (Q52092430)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

title

Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

neurodevelopmental disorder

22 March 2020

main subject

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Lucy A Crompton

1 reference

22 April 2018

http://europepmc.org/abstract/MED/28585380

Oscar Cordero-Llana

series ordinal

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22 April 2018

http://europepmc.org/abstract/MED/28585380

Maeve A Caldwell

series ordinal

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22 April 2018

http://europepmc.org/abstract/MED/28585380

publication date

1 July 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

530-544

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

22 March 2020

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Regulation of synaptic connectivity by glia

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Genetics of Alzheimer's disease: a centennial review

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In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

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DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.

21 January 2018

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

21 January 2018

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An updated review of Parkinson's disease genetics and clinicopathological correlations.

21 January 2018

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Mammalian neural stem cells

21 January 2018

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Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture.

21 January 2018

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Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.

21 January 2018

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Mechanisms of neurodegeneration in Huntington's disease.

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

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Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms.

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Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.

21 January 2018

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The glia/neuron ratio: how it varies uniformly across brain structures and species and what that means for brain physiology and evolution

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Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code

21 January 2018

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Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP

21 January 2018

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S100 beta stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes

21 January 2018

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BMP signaling mediates astrocyte differentiation of oligodendrocyte progenitor cells

21 January 2018

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Glial regulation of the cerebral microvasculature

21 January 2018

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Oxidative stress and the pathogenesis of Parkinson's disease

21 January 2018

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Aberrant iPSC-derived human astrocytes in Alzheimer's disease.

21 January 2018

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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells

21 January 2018

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21 January 2018

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Amyotrophic lateral sclerosis

21 January 2018

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The role of apolipoprotein E in Alzheimer's disease

21 January 2018

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Astrocytes and the regulation of cerebral blood flow

21 January 2018

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Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

21 January 2018

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Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

21 January 2018

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Astrocyte differentiation mediated by LIF in cooperation with BMP2

21 January 2018

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Committed neuronal precursors confer astrocytic potential on residual neural precursor cells.

21 January 2018

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Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease

21 January 2018

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Astrocytic complexity distinguishes the human brain

21 January 2018

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21 January 2018

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Astrocytes are endogenous regulators of basal transmission at central synapses

21 January 2018

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21 January 2018

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SMN deficiency does not induce oxidative stress in SMA iPSC-derived astrocytes or motor neurons

21 January 2018

1 reference

Reactive gliosis in the pathogenesis of CNS diseases

21 January 2018

1 reference

Activity-dependent regulation of energy metabolism by astrocytes: an update

21 January 2018

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Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes

21 January 2018

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Target-derived astroglia regulate axonal outgrowth in a region-specific manner

21 January 2018

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A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

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Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

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Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling

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Focal degeneration of astrocytes in amyotrophic lateral sclerosis.

21 January 2018

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

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Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

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Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

21 January 2018

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Astroglial metabolic networks sustain hippocampal synaptic transmission

21 January 2018

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Amyotrophic lateral sclerosis

21 January 2018

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Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes

21 January 2018

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Review of Alexander disease: beyond the classical concept of leukodystrophy

21 January 2018

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Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?

21 January 2018

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Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy.

21 January 2018

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Histone deacetylases control neurogenesis in embryonic brain by inhibition of BMP2/4 signaling

21 January 2018

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A human stem cell model of early Alzheimer's disease pathology in Down syndrome

21 January 2018

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Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

21 January 2018

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Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.

21 January 2018

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21 January 2018

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Midbrain neuronal cultures from parkin mutant mice are resistant to nitric oxide-induced toxicity

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DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain.

21 January 2018

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Decoding ALS: from genes to mechanism.

21 January 2018

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The development of neural stem cells

21 January 2018

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Amyloid beta-protein (Abeta)-containing astrocytes are located preferentially near N-terminal-truncated Abeta deposits in the human entorhinal cortex.

21 January 2018

1 reference

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

21 January 2018

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Human embryonic stem cells: an in vitro model to study mechanisms controlling pluripotency in early mammalian development

21 January 2018

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Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways

21 January 2018

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Deficits in human trisomy 21 iPSCs and neurons

21 January 2018

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

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Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

21 January 2018

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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

21 January 2018

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Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

21 January 2018

1 reference

RETRACTED: In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling

21 January 2018

1 reference

Genomic analysis of reactive astrogliosis

21 January 2018

1 reference

Association of LRRK2 R1628P variant with Parkinson's disease in Ethnic Han-Chinese and subgroup population

21 January 2018

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21 January 2018

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Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

21 January 2018

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Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/BPA.12522

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28585380%20AND%20SRC:MED&resulttype=core&format=json