Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From C2 Toxin (Q59335550)

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scholarly article by Katharina Ernst et al published 2018 in Frontiers in Pharmacology

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English	Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From C2 Toxin	scholarly article by Katharina Ernst et al published 2018 in Frontiers in Pharmacology

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instance of

scholarly article

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title

Combined Pharmacological Inhibition of Cyclophilins, FK506-Binding Proteins, Hsp90, and Hsp70 Protects Cells From C2 Toxin (English)

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main subject

pharmacology

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based on heuristic

inferred from title

author name string

Katharina Ernst

series ordinal

1

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Carolin Kling

series ordinal

2

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Marc Landenberger

series ordinal

3

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Holger Barth

series ordinal

4

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language of work or name

English

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publication date

2018

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published in

Frontiers in Pharmacology

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volume

9

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page(s)

1287

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copyright license

Creative Commons Attribution 4.0 International

start time

13 November 2018

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stated in

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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stated in

Europe PubMed Central

retrieved

11 June 2022

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6243138/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Biological effects of cyclosporin A: A new antilymphocytic agent

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Immunophilin-ligand complexes as probes of intracellular signaling pathways

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Botulinum C2 toxin ADP-ribosylates actin and disorganizes the microfilament network in intact cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Fluid accumulation in the ligated intestinal loop and histopathological changes of the intestinal mucosa caused by Clostridium botulinum C2 toxin in the pheasant and chicken

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Botulinum C2 toxin ADP-ribosylates actin

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the pharmacological properties of Clostridium botulinum type C1 and C2 toxins

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Response of mouse intestinal loop to botulinum C2 toxin: enterotoxic activity induced by cooperation of nonlinked protein components

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Lethal and vascular permeability activities of botulinum C2 toxin induced by separate injections of the two toxin components.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Diphtheria toxin entry into cells is facilitated by low pH.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

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The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Clostridial enteric diseases of domestic animals

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Clostridium perfringens type E animal enteritis isolates with highly conserved, silent enterotoxin gene sequences.

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

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inferred from PubMed ID database lookup

The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and action of the binary C2 toxin from Clostridium botulinum

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of a biologically active toxin complex of the binary Clostridium botulinum C2 toxin without cell membrane interaction

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Importing mitochondrial proteins: machineries and mechanisms

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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inferred from PubMed ID database lookup

New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fine tuning the inhibition profile of cyclosporine A by derivatization of the MeBmt residue

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure, function and regulation of the hsp90 machinery

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

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stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co- and post-translocation roles for HSP90 in cholera Intoxication

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multidomain Peptidyl Prolyl cis/trans Isomerases

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of pertussis toxin to the pathogenesis of pertussis disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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Pertussis vaccines: WHO position paper, August 2015--Recommendations

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

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A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins

1 reference

stated in

PubMed

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https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridial Binary Toxins: Basic Understandings that Include Cell Surface Binding and an Internal "Coup de Grâce".

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HSP90 chaperone machinery

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clostridium difficile Toxin Biology

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular Uptake and Mode-of-Action of Clostridium difficile Toxins

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological Cyclophilin Inhibitors Prevent Intoxication of Mammalian Cells with Bordetella pertussis Toxin.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30483129

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.3389/FPHAR.2018.01287

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PMC publication ID

6243138

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PubMed publication ID

30483129

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