Clostridial Binary Toxins: Basic Understandings that Include Cell Surface Binding and an Internal "Coup de Grâce". (Q38845075)

6 September 2017

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title

Clostridial Binary Toxins: Basic Understandings that Include Cell Surface Binding and an Internal "Coup de Grâce". (English)

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6 September 2017

Bradley G Stiles

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6 September 2017

publication date

6 July 2016

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Current Topics in Microbiology and Immunology

6 September 2017

published in

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Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

6 September 2017

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Inhibitions of the translocation pore of Clostridium botulinum C2 toxin by tailored azolopyridinium salts protects human cells from intoxication.

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Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms

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Cell entry and cAMP imaging of anthrax edema toxin

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Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

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Prevalence and pathogenicity of binary toxin-positive Clostridium difficile strains that do not produce toxins A and B

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Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

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Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

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A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

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Discovery of new cargo proteins that enter cells through clathrin-independent endocytosis

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Internalization of biotinylated compounds into cancer cells is promoted by a molecular Trojan horse based upon core streptavidin and clostridial C2 toxin

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Towards an international standard for detection and typing botulinum neurotoxin-producing Clostridia types A, B, E and F in food, feed and environmental samples: a European ring trial study to evaluate a real-time PCR assay.

21 January 2018

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Characterization of component-I gene of botulinum C2 toxin and PCR detection of its gene in clostridial species

21 January 2018

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Clostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importance

21 January 2018

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Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters

21 January 2018

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Clostridium perfringens iota-toxin requires activation of both binding and enzymatic components for cytopathic activity

21 January 2018

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Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile

21 January 2018

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Detergent-resistant membrane microdomains facilitate Ib oligomer formation and biological activity of Clostridium perfringens iota-toxin

21 January 2018

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INTESTINAL FLORA IN NEW-BORN INFANTS

21 January 2018

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Cyclophilin: a specific cytosolic binding protein for cyclosporin A

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21 January 2018

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21 January 2018

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Involvement of CD44v6 in InlB-dependent Listeria invasion

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Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

21 January 2018

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Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

21 January 2018

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The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization

21 January 2018

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The gene for component-II of botulinum C2 toxin

21 January 2018

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Clostridium perfringens enterotoxin interacts with claudins via electrostatic attraction

21 January 2018

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Interaction of Clostridium perfringens iota-toxin with lipid bilayer membranes. Demonstration of channel formation by the activated binding component Ib and channel block by the enzyme component Ia.

21 January 2018

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Pore-forming activity of clostridial binary toxins

21 January 2018

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Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain

21 January 2018

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Initial steps of Shigella infection depend on the cholesterol/sphingolipid raft-mediated CD44-IpaB interaction

21 January 2018

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Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway

21 January 2018

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Clostridium difficile and the aetiology of pseudomembranous colitis

21 January 2018

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Community-associated Clostridium difficile infection: how real is it?

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Burden of Clostridium difficile infection in the United States

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A possible route for foodborne transmission of Clostridium difficile?

21 January 2018

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Clostridium perfringens iota-toxin: mapping of receptor binding and Ia docking domains on Ib.

21 January 2018

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Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization.

21 January 2018

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LSR defines cell corners for tricellular tight junction formation in epithelial cells

21 January 2018

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Identification of Novel Clostridium perfringens Type E Strains That Carry an Iota Toxin Plasmid with a Functional Enterotoxin Gene

21 January 2018

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Four foodborne disease outbreaks caused by a new type of enterotoxin-producing Clostridium perfringens

21 January 2018

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Structural Basis for CD44 Recognition by ERM Proteins

21 January 2018

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Characterization of the enzymatic component of Clostridium perfringens iota-toxin

21 January 2018

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Binding component of Clostridium perfringens iota-toxin induces endocytosis in Vero cells

21 January 2018

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Binding and internalization of Clostridium perfringens iota-toxin in lipid rafts

21 January 2018

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Binding and internalization of Clostridium botulinum C2 toxin

21 January 2018

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Clostridium perfringens iota-toxin b induces rapid cell necrosis

21 January 2018

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Intracellular trafficking of Clostridium perfringens iota-toxin b.

21 January 2018

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Intracellular trafficking of Clostridium botulinum C2 toxin

21 January 2018

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Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor

21 January 2018

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Speculation and C2Toxin Production byClostridium botulinumType C Strains Producing No C1Toxin

21 January 2018

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Tailored ß-cyclodextrin blocks the translocation pores of binary exotoxins from C. botulinum and C. perfringens and protects cells from intoxication

21 January 2018

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Clostridium botulinum C2 toxin. Identification of the binding site for chloroquine and related compounds and influence of the binding site on properties of the C2II channel

21 January 2018

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Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome

21 January 2018

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Routine typing of Clostridium welchii

21 January 2018

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Purification and characterization of heterologous component IIs of botulinum C2 toxin

21 January 2018

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ADP-ribosylation of nonmuscle actin with component I of C2 toxin

21 January 2018

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Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

21 January 2018

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Identification of the cellular receptor of Clostridium spiroforme toxin

21 January 2018

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Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts

21 January 2018

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Crystal structure of the anthrax toxin protective antigen

21 January 2018

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The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior

21 January 2018

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Clostridium perfringens type E virulence traits involved in gut colonization

21 January 2018

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Transcytosis of iota-toxin across polarized CaCo-2 cells

21 January 2018

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Urothelial CD44 facilitates Escherichia coli infection of the murine urinary tract

21 January 2018

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Lethal and Dermonecrotic Activities of Clostridium perfringens Iota Toxin: Biological Activities Induced by Cooperation of Two Nonlinked Components

21 January 2018

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Clostridium perfringens iota-toxin: structure and function.

21 January 2018

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Novel receptors for bacterial protein toxins

21 January 2018

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Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

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Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

21 January 2018

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Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

21 January 2018

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Clostridium difficile toxins: mediators of inflammation.

21 January 2018

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Generation and characterization of recombinant bivalent fusion protein r-Cpib for immunotherapy against Clostridium perfringens beta and iota toxemia

21 January 2018

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Cholesterol, lipid rafts, and disease

21 January 2018

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Clostridium perfringens type E enteritis in calves: two cases and a brief review of the literature

21 January 2018

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Up-regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin: a potential lever for controlling lipid clearance during the postprandial phase

21 January 2018

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Functional characterization of an extended binding component of the actin-ADP-ribosylating C2 toxin detected in Clostridium botulinum strain (C) 2300.

21 January 2018

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Clostridium perfringens iota toxin: synergism between two proteins

21 January 2018

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Clostridium perfringens iota toxin: binding studies and characterization of cell surface receptor by fluorescence-activated cytometry

21 January 2018

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Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry

21 January 2018

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Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex

21 January 2018

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Clostridial binary toxins: iota and C2 family portraits

21 January 2018

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The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection

21 January 2018

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Crystal structure and site-directed mutagenesis of enzymatic components from Clostridium perfringens iota-toxin

21 January 2018

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Structural basis of actin recognition and arginine ADP-ribosylation by Clostridium perfringens -toxin

21 January 2018

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Arginine ADP-ribosylation mechanism based on structural snapshots of iota-toxin and actin complex

21 January 2018

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Receptors of anthrax toxin and cell entry.

21 January 2018

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Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.

21 January 2018

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Characterization of membrane translocation by anthrax protective antigen

21 January 2018

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CD44 Promotes intoxication by the clostridial iota-family toxins

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2016_11

Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2016_11

Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2016_11

BEC, a novel enterotoxin of Clostridium perfringens found in human clinical isolates from acute gastroenteritis outbreaks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2016_11

Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2016_11

The phylogeny of prokaryotes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1007/82_2016_11

0 references

1 reference