Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells (Q30313128)

16 October 2017

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells (English)

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16 October 2017

Klaus Aktories

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Cordelia Schiene-Fischer

object named as

Cordelia Schiene-Fischer

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Holger Barth

object named as

Holger Barth

1 reference

16 October 2017

Michael Fauler

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16 October 2017

Katharina Ernst

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16 October 2017

Johannes Schmid

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16 October 2017

Matthias Beck

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16 October 2017

Marlen Hägele

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16 October 2017

Meike Hohwieler

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16 October 2017

Patricia Hauff

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16 October 2017

Anna Katharina Ückert

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16 October 2017

Anna Anastasia

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16 October 2017

Thomas Jank

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16 October 2017

Michel R Popoff

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16 October 2017

Alexander Kleger

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16 October 2017

Martin Müller

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16 October 2017

Manfred Frick

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16 October 2017

language of work or name

English

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publication date

2 June 2017

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16 October 2017

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16 October 2017

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16 October 2017

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16 October 2017

2724

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Creative Commons Attribution 4.0 International

16 October 2017

start time

2 June 2017

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5457432/fullTextXML

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CD44 Promotes intoxication by the clostridial iota-family toxins

3 June 2018

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Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA)

3 June 2018

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Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process

3 June 2018

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The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

3 June 2018

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Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

3 June 2018

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Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

3 June 2018

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

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Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

3 June 2018

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Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol

3 June 2018

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Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis

3 June 2018

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Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering

3 June 2018

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Functional characterization of an extended binding component of the actin-ADP-ribosylating C2 toxin detected in Clostridium botulinum strain (C) 2300.

3 June 2018

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Selective and specific internalization of clostridial C3 ADP-ribosyltransferases into macrophages and monocytes

3 June 2018

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Importing mitochondrial proteins: machineries and mechanisms

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

3 June 2018

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

3 June 2018

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Binary actin-ADP-ribosylating toxins and their use as molecular Trojan horses for drug delivery into eukaryotic cells

3 June 2018

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3 June 2018

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

3 June 2018

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The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia

3 June 2018

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Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins

3 June 2018

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The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

3 June 2018

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The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

3 June 2018

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The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex

3 June 2018

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Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Analysis of molecular chaperone activities using in vitro and in vivo approaches.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Characterization of membrane translocation by anthrax protective antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Steroid receptor interactions with heat shock protein and immunophilin chaperones

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Production of a complete binary toxin (actin-specific ADP-ribosyltransferase) by Clostridium difficile CD196.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Clostridial enteric diseases of domestic animals

3 June 2018

1 reference

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Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Lethal and vascular permeability activities of botulinum C2 toxin induced by separate injections of the two toxin components.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Purification and characterization of Clostridium perfringens iota toxin: dependence on two nonlinked proteins for biological activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain

3 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-02882-Y

Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-02882-Y

The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-02882-Y

Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-02882-Y

"Miniguts" from plucked human hair meet Crohn's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5457432

Botulinum C2 toxin ADP-ribosylates actin

26 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-02882-Y

Botulinum C2 toxin ADP-ribosylates actin and disorganizes the microfilament network in intact cells

21 January 2018

1 reference

12 December 2020

ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin

1 reference

12 December 2020

ADP-ribosylation of actin causes increase in the rate of ATP exchange and inhibition of ATP hydrolysis

1 reference

12 December 2020

Fluid accumulation in the ligated intestinal loop and histopathological changes of the intestinal mucosa caused by Clostridium botulinum C2 toxin in the pheasant and chicken

1 reference

12 December 2020

Structure and action of the binary C2 toxin from Clostridium botulinum

1 reference

12 December 2020

9-donor-substituted acridizinium salts: versatile environment-sensitive fluorophores for the detection of biomacromolecules

1 reference

12 December 2020

FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells

1 reference

12 December 2020

ADP-ribosylated actin caps the barbed ends of actin filaments

1 reference

12 December 2020

Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis

1 reference

12 December 2020

10.1038/S41598-017-02882-Y

Identifiers

DOI

1 reference

Dimensions Publication ID

16 October 2017

0 references

1 reference

16 October 2017

PubMed publication ID

28578412

1 reference