The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells (Q30313276)

14 October 2017

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells (English)

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14 October 2017

Klaus Aktories

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Cordelia Schiene-Fischer

object named as

Cordelia Schiene-Fischer

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author name string

Manuel Schuster

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14 October 2017

Leonie Schnell

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14 October 2017

Peter Feigl

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14 October 2017

Carina Birkhofer

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14 October 2017

Katharina Mohr

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14 October 2017

Maurice Roeder

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14 October 2017

Stefan Carle

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14 October 2017

Simon Langer

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14 October 2017

Franziska Tippel

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14 October 2017

Johannes Buchner

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14 October 2017

Gunter Fischer

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14 October 2017

Felix Hausch

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14 October 2017

Manfred Frick

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14 October 2017

Carsten Schwan

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14 October 2017

Holger Barth

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14 October 2017

language of work or name

English

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publication date

4 April 2017

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14 October 2017

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14 October 2017

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14 October 2017

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14 October 2017

613

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Creative Commons Attribution 4.0 International

14 October 2017

start time

4 April 2017

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April 2022 Public Data File from Crossref

copyrighted

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cites work

A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

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Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands

3 June 2018

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Selective inhibitors of the FK506-binding protein 51 by induced fit

3 June 2018

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Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

3 June 2018

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Functional aspects of extracellular cyclophilins

3 June 2018

1 reference

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Diphtheria toxin conformational switching at acidic pH

3 June 2018

1 reference

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Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147.

3 June 2018

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InterAKTions with FKBPs--mutational and pharmacological exploration

3 June 2018

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Large FK506-Binding Proteins Shape the Pharmacology of Rapamycin

3 June 2018

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Fine tuning the inhibition profile of cyclosporine A by derivatization of the MeBmt residue

3 June 2018

1 reference

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Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process

3 June 2018

1 reference

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Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

3 June 2018

1 reference

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Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors

3 June 2018

1 reference

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Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

3 June 2018

1 reference

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Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol

3 June 2018

1 reference

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design

3 June 2018

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Conserved conformational changes in the ATPase cycle of human Hsp90.

3 June 2018

1 reference

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The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol

3 June 2018

1 reference

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The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

3 June 2018

1 reference

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Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions

3 June 2018

1 reference

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The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

3 June 2018

1 reference

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The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex

3 June 2018

1 reference

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Thermodynamic characterization of the interaction of human cyclophilin 18 with cyclosporin A.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

The hsp70 chaperone DnaK is a secondary amide peptide bond cis-trans isomerase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Two structures of cyclophilin 40: folding and fidelity in the TPR domains

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Steroid receptor interactions with heat shock protein and immunophilin chaperones

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

The role of proline 345 in diphtheria toxin translocation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Prolyl isomerases: role in protein folding.

3 June 2018

1 reference

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Evidence for involvement of furin in cleavage and activation of diphtheria toxin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Inhibition of membrane translocation of diphtheria toxin A-fragment by internal disulfide bridges

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Prolyl isomerase: enzymatic catalysis of slow protein-folding reactions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Diphtheria: changing patterns in the developing world and the industrialized world

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Diphtheria toxin entry into cells is facilitated by low pH.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Structure and activity of diphtheria toxin. I. Thiol-dependent dissociation of a fraction of toxin into enzymically active and inactive fragments

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

On the membrane translocation of diphtheria toxin: at low pH the toxin induces ion channels on cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Elimination of the disulphide bridge in fragment B of diphtheria toxin: effect on membrane insertion, channel formation, and ATP binding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

The crystal structure of diphtheria toxin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Membrane translocation of diphtheria toxin A-fragment: role of carboxy-terminal region.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-00780-X

Concerted protonation of key histidines triggers membrane interaction of the diphtheria toxin T domain.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-00780-X

Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-00780-X

The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Diphtheria toxin-induced channels in Vero cells selective for monovalent cations.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5429619

Replacement of negative by positive charges in the presumed membrane-inserted part of diphtheria toxin B fragment. Effect on membrane translocation and on formation of cation channels

26 November 2018

1 reference

12 December 2020

Membrane translocation of diphtheria toxin fragment A exploits early to late endosome trafficking machinery

1 reference

12 December 2020

The cytotoxic action of diphtheria toxin and its degradation in intact Vero cells are inhibited by bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase

1 reference

12 December 2020

Diphtheria toxin subunit active in vitro

1 reference

12 December 2020

Cell-mediated reduction of the interfragment disulfide in nicked diphtheria toxin. A new system to study toxin entry at low pH

1 reference

12 December 2020

Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication

1 reference

12 December 2020

Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule

1 reference

12 December 2020

Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule

1 reference

12 December 2020

One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell

1 reference

12 December 2020

Structure-Activity Relationships in Diphtheria Toxin

1 reference

12 December 2020

Intermediates in translocation of diphtheria toxin across the plasma membrane

1 reference

12 December 2020

Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding

1 reference

12 December 2020

FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells

1 reference

12 December 2020

Insertion of diphtheria toxin B-fragment into the plasma membrane at low pH. Characterization and topology of inserted regions

1 reference

12 December 2020

Conservation of Hsp90 macromolecular complexes in Saccharomyces cerevisiae

1 reference

12 December 2020

Cell penetration of diphtheria toxin. Reduction of the interchain disulfide bridge is the rate-limiting step of translocation in the cytosol

1 reference

12 December 2020

10.1038/S41598-017-00780-X

Identifiers

DOI

1 reference

Dimensions Publication ID

14 October 2017

0 references

1 reference

14 October 2017

PubMed publication ID

28377614

1 reference