ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins (Q51696863)

10 April 2018

review article

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title

ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins (English)

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10 April 2018

author name string

Klaus Aktories

series ordinal

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10 April 2018

Carsten Schwan

series ordinal

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10 April 2018

Alexander E Lang

series ordinal

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10 April 2018

publication date

18 June 2016

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10 April 2018

Handbook of experimental pharmacology

published in

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10 April 2018

volume

235

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10 April 2018

page(s)

179-206

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10 April 2018

Bacterial protein toxins that modify host regulatory GTPases

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Xenorhabdus and Photorhabdus spp.: bugs that kill bugs

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A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion

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Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility

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Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex

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S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.

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The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

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The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

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ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death.

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ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

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Actin and cell pathogenesis

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Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins

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Atomic model of the actin filament

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Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

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A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins

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Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos

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The regulation of pathogenicity and mutualism in Photorhabdus

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Glucosylation of Rho proteins by Clostridium difficile toxin B.

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Atomic structure of the actin:DNase I complex

21 January 2018

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Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

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Structure of Shigella IpgB2 in Complex with Human RhoA: IMPLICATIONS FOR THE MECHANISM OF BACTERIAL GUANINE NUCLEOTIDE EXCHANGE FACTOR MIMICRY

21 January 2018

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Interaction of Clostridium perfringens iota-toxin with lipid bilayer membranes. Demonstration of channel formation by the activated binding component Ib and channel block by the enzyme component Ia.

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Control of the assembly of ATP- and ADP-actin by formins and profilin.

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Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein

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Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin

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Glutamyl phosphate is an activated intermediate in actin crosslinking by actin crosslinking domain (ACD) toxin

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Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering

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Hijacking of Rho GTPases during bacterial infection

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The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells

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Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets

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The beta-thymosins: intracellular and extracellular activities of a versatile actin binding protein family

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A steric antagonism of actin polymerization by a salmonella virulence protein

21 January 2018

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LSR defines cell corners for tricellular tight junction formation in epithelial cells

21 January 2018

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Actin involvement in exocytosis from PC12 cells: studies on the influence of botulinum C2 toxin on stimulated noradrenaline release

21 January 2018

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Mechanism of Tc toxin action revealed in molecular detail

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Binding component of Clostridium perfringens iota-toxin induces endocytosis in Vero cells

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Binding and internalization of Clostridium perfringens iota-toxin in lipid rafts

21 January 2018

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Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils

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Identification of the cellular receptor of Clostridium spiroforme toxin

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Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts

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Microinjection of recombinant p21rho induces rapid changes in cell morphology

21 January 2018

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Dimeric WH2 domains in Vibrio VopF promote actin filament barbed-end uncapping and assisted elongation

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Bacterial factors exploit eukaryotic Rho GTPase signaling cascades to promote invasion and proliferation within their host

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Actin Crosslinking Toxins of Gram-Negative Bacteria

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Multifunctional-autoprocessing repeats-in-toxin (MARTX) Toxins of Vibrios

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Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1.

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Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

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Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

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Actin dependence of polarized receptor recycling in Madin-Darby canine kidney cell endosomes

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Clostridium perfringens iota toxin: synergism between two proteins

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A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin

21 January 2018

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Actin cross-linking domain of Aeromonas hydrophila repeat in toxin A (RtxA) induces host cell rounding and apoptosis

21 January 2018

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Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro

21 January 2018

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Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri

21 January 2018

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A type III secretion system in Vibrio cholerae translocates a formin/spire hybrid-like actin nucleator to promote intestinal colonization.

21 January 2018

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Actin is ADP-ribosylated by the Salmonella enterica virulence-associated protein SpvB.

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Disassembly of actin filaments by botulinum C2 toxin and actin-filament-disrupting agents induces assembly of microtubules in human leukaemia cell lines

21 January 2018

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The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42

21 January 2018

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Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.

21 January 2018

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Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system

21 January 2018

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Photox, a novel actin-targeting mono-ADP-ribosyltransferase from Photorhabdus luminescens

21 January 2018

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GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure

21 January 2018

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Photorhabdus and a host of hosts

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Biochemical consequences of the cardiofunk (R177H) mutation in yeast actin

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AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling

21 January 2018

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Anthrax toxin: receptor binding, internalization, pore formation, and translocation

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The insect toxin complex of Yersinia

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Mutational analysis of arginine 177 in the nucleotide binding site of β-actin

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Botulinum C2 toxin ADP-ribosylates actin

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AeromonasExoenzyme T ofAeromonas salmonicidaIs a Bifunctional Protein That Targets the Host Cytoskeleton

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21 January 2018

Identifiers

DOI

10.1007/164_2016_26

1 reference

10 April 2018

1 reference

10 April 2018