A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9 (Q41294785)

29 September 2017

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9 (English)

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29 September 2017

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9 June 2020

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9 June 2020

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9 June 2020

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9 June 2020

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9 June 2020

Samuel H Sternberg

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29 September 2017

Janice S Chen

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29 September 2017

language of work or name

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4 August 2017

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29 September 2017

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9 June 2020

volume

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9 June 2020

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9 June 2020

page(s)

eaao0027

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Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease

9 June 2020

cites work

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Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

1 October 2017

1 reference

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Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9.

1 October 2017

1 reference

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Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

1 October 2017

1 reference

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Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.

1 October 2017

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Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9

1 October 2017

1 reference

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Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

1 October 2017

1 reference

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Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering

1 October 2017

1 reference

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High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Rationally engineered Cas9 nucleases with improved specificity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Conformational control of DNA target cleavage by CRISPR-Cas9.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

1 October 2017

1 reference

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Delivery and Specificity of CRISPR-Cas9 Genome Editing Technologies for Human Gene Therapy.

1 October 2017

1 reference

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Expanding the Biologist's Toolkit with CRISPR-Cas9

1 October 2017

1 reference

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Target specificity of the CRISPR-Cas9 system.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

1 October 2017

1 reference

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Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Unravelling the structural and mechanistic basis of CRISPR-Cas systems

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Development and applications of CRISPR-Cas9 for genome engineering

1 October 2017

1 reference

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CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity

1 October 2017

1 reference

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Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

1 October 2017

1 reference

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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

1 October 2017

1 reference

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

1 October 2017

1 reference

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

1 October 2017

1 reference

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

Single-molecule studies of synaptotagmin and complexin binding to the SNARE complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5547770

1 October 2017

Identifiers

DOI

10.1126/SCIADV.AAO0027

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28808686%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

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9 June 2020

PubMed publication ID

28808686

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28808686%20AND%20SRC:MED&resulttype=core&format=json