Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems (Q34536517)

2 August 2017

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title

Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems (English)

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2 August 2017

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John van der Oost

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Eugene Koonin

series ordinal

object named as

Eugene V Koonin

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2 August 2017

Kira S Makarova

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2 August 2017

Bernd Zetsche

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2 August 2017

Prarthana Mohanraju

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2 August 2017

Feng Zhang

series ordinal

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2 August 2017

language of work or name

English

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publication date

1 August 2016

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2 August 2017

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2 August 2017

volume

353

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2 August 2017

issue

6299

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2 August 2017

page(s)

aad5147

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A virocentric perspective on the evolution of life

2 August 2017

cites work

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CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

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RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

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Small CRISPR RNAs guide antiviral defense in prokaryotes

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CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA

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The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

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CRISPR-based adaptive immune systems

21 January 2018

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Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements

21 January 2018

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Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

21 January 2018

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CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies.

21 January 2018

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A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action

21 January 2018

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CRISPR-based adaptive and heritable immunity in prokaryotes

21 January 2018

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RNA-guided genetic silencing systems in bacteria and archaea

21 January 2018

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CRISPR-Cas systems: Prokaryotes upgrade to adaptive immunity

21 January 2018

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CRISPR-Cas immunity in prokaryotes

21 January 2018

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Molecular mechanisms of CRISPR-mediated microbial immunity

21 January 2018

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CRISPR-Cas systems: beyond adaptive immunity

21 January 2018

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CRISPR-Cas systems: new players in gene regulation and bacterial physiology

21 January 2018

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The role of CRISPR-Cas systems in virulence of pathogenic bacteria

21 January 2018

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Nature and intensity of selection pressure on CRISPR-associated genes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Evolution of the CRISPR-Cas adaptive immunity systems in prokaryotes: models and observations on virus-host coevolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

An updated evolutionary classification of CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

The basic building blocks and evolution of CRISPR-CAS systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structure of the CRISPR interference complex CSM reveals key similarities with cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structure of an RNA silencing complex of the CRISPR-Cas immune system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Classification and evolution of type II CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

The casposon-encoded Cas1 protein from Aciduliprofundum boonei is a DNA integrase that generates target site duplications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Recent Mobility of Casposons, Self-Synthesizing Transposons at the Origin of the CRISPR-Cas Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Evolution of adaptive immunity from transposable elements combined with innate immune systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

ISC, a Novel Group of Bacterial and Archaeal DNA Transposons That Encode Cas9 Homologs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-Cas adaptation: insights into the mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Phage response to CRISPR-encoded resistance in Streptococcus thermophilus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR interference directs strand specific spacer acquisition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Self-targeting by CRISPR: gene regulation or autoimmunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas9 function and host genome sampling in Type II-A CRISPR-Cas adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR adaptation biases explain preference for acquisition of foreign DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Inter-viral conflicts that exploit host CRISPR immune systems of Sulfolobus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-Cas and restriction-modification systems are compatible and increase phage resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase-Cas1 fusion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Memory of viral infections by CRISPR-Cas adaptive immune systems: acquisition of new information

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Detection and characterization of spacer integration intermediates in type I-E CRISPR-Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Degenerate target sites mediate rapid primed CRISPR adaptation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR interference and priming varies with individual spacer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Different genome stability proteins underpin primed and naïve adaptation in E. coli CRISPR-Cas immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas9 specifies functional viral targets during CRISPR-Cas adaptation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural basis for CRISPR RNA-guided DNA recognition by Cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR interference: a structural perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structures of the RNA-guided surveillance complex from a bacterial immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Three CRISPR-Cas immune effector complexes coexist in Pyrococcus furiosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

A ruler protein in a complex for antiviral defense determines the length of small interfering CRISPR RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-Cas Adaptive Immune Systems of the Sulfolobales: Unravelling Their Complexity and Diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Two distinct DNA binding modes guide dual roles of a CRISPR-Cas protein complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Crystal structure of the CRISPR-Cas RNA silencing Cmr complex bound to a target analog

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-mediated targeted mRNA degradation in the archaeon Sulfolobus solfataricus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

RNA-activated DNA cleavage by the Type III-B CRISPR-Cas effector complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR-Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Target RNA capture and cleavage by the Cmr type III-B CRISPR-Cas effector complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural model of a CRISPR RNA-silencing complex reveals the RNA-target cleavage activity in Cmr4

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Essential structural and functional roles of the Cmr4 subunit in RNA cleavage by the Cmr CRISPR-Cas complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Staphylococcus epidermidis Csm1 is a 3'-5' exonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific endoribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Self versus non-self discrimination during CRISPR RNA-directed immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Unravelling the structural and mechanistic basis of CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Conformational control of DNA target cleavage by CRISPR-Cas9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cleavage of phage DNA by the Streptococcus thermophilus CRISPR3-Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

DNase H Activity of Neisseria meningitidis Cas9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Development and applications of CRISPR-Cas9 for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

MIMIVIRE is a defence system in mimivirus that confers resistance to virophage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

RNA-guided human genome engineering via Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

RNA-programmed genome editing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR transcriptional repression devices and layered circuits in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Cas9 as a versatile tool for engineering biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

A split-Cas9 architecture for inducible genome editing and transcription modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Small molecule-triggered Cas9 protein with improved genome-editing specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Rationally engineered Cas9 nucleases with improved specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

In vivo genome editing using Staphylococcus aureus Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

Concerning RNA-guided gene drives for the alteration of wild populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5147

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAD5147

1 reference

2 August 2017

1 reference