Chromatin modifications as therapeutic targets in MLL-rearranged leukemia (Q33666543)

28 July 2017

title

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia (English)

1 reference

28 July 2017

1 reference

Aniruddha J Deshpande

series ordinal

1 reference

28 July 2017

James Bradner

series ordinal

1 reference

28 July 2017

Scott A Armstrong

series ordinal

1 reference

28 July 2017

publication date

3 August 2012

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28 July 2017

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28 July 2017

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28 July 2017

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28 July 2017

page(s)

563-570

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Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia

28 July 2017

cites work

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CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis

21 June 2018

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The pathogenesis of mixed-lineage leukemia

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 June 2018

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Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

21 June 2018

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Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification

21 June 2018

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An open and shut case for the role of NSD proteins as oncogenes

21 June 2018

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Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes

21 June 2018

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 June 2018

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Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin

21 June 2018

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 June 2018

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 June 2018

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 June 2018

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Cancers and the NSD family of histone lysine methyltransferases.

21 June 2018

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Epigenetics in cancer: what's the future?

21 June 2018

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DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

21 June 2018

1 reference

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Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

21 June 2018

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Initial genome sequencing and analysis of multiple myeloma

21 June 2018

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Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

21 June 2018

1 reference

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Aberrations of EZH2 in cancer

21 June 2018

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KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

21 June 2018

1 reference

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Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

21 June 2018

1 reference

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β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells

21 June 2018

1 reference

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Suppression of inflammation by a synthetic histone mimic

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Flavopiridol, the First Cyclin-Dependent Kinase Inhibitor: Recent Advances in Combination Chemotherapy

21 June 2018

1 reference

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PAFc, a key player in MLL-rearranged leukemogenesis

21 June 2018

1 reference

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Selective inhibition of BET bromodomains

21 June 2018

1 reference

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MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia

21 June 2018

1 reference

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The clinical development of histone deacetylase inhibitors as targeted anticancer drugs

21 June 2018

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Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

21 June 2018

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The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

21 June 2018

1 reference

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Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 June 2018

1 reference

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The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

21 June 2018

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CDK inhibitors: from the bench to clinical trials.

21 June 2018

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Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

21 June 2018

1 reference

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MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

21 June 2018

1 reference

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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Misguided transcriptional elongation causes mixed lineage leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The molecular biology of mixed lineage leukemia

21 June 2018

1 reference

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Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.

21 June 2018

1 reference

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Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Therapeutic targeting of MLL.

21 June 2018

1 reference

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Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The PHD fingers of MLL block MLL fusion protein-mediated transformation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The multi-tasking P-TEFb complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL translocations, histone modifications and leukaemia stem-cell development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Protein arginine-methyltransferase-dependent oncogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.

21 June 2018

1 reference

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ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias

21 June 2018

1 reference

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MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Chromatin modifications and their function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L

21 June 2018

1 reference

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Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

hDOT1L links histone methylation to leukemogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL targets SET domain methyltransferase activity to Hox gene promoters

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Gene silencing: trans-histone regulatory pathway in chromatin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Dot1p modulates silencing in yeast by methylation of the nucleosome core

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Biological and therapeutic aspects of infant leukemia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Essential role of DOT1L in maintaining normal adult hematopoiesis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

New insights to the MLL recombinome of acute leukemias

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034385

The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22867873

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/22867873

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.IT.2012.06.002

1 reference

28 July 2017

1 reference

28 July 2017

1 reference