Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells? (Q53325167)

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scientific article published on 8 May 2010

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English	Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?	scientific article published on 8 May 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

20454944

retrieved

13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

title

Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells? (English)

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Europe PubMed Central

PubMed publication ID

20454944

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13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

main subject

leukemia

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based on heuristic

inferred from title

author

Tim C P Somervaille

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Tim C P Somervaille

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Europe PubMed Central

PubMed publication ID

20454944

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13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

author name string

Michael L Cleary

series ordinal

2

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Europe PubMed Central

PubMed publication ID

20454944

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13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

publication date

8 May 2010

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Europe PubMed Central

PubMed publication ID

20454944

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13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

published in

International Journal of Hematology

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Europe PubMed Central

PubMed publication ID

20454944

retrieved

13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

volume

91

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Europe PubMed Central

PubMed publication ID

20454944

retrieved

13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

issue

5

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Europe PubMed Central

PubMed publication ID

20454944

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13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

page(s)

735-741

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Europe PubMed Central

PubMed publication ID

20454944

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13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

cites work

Protein arginine-methyltransferase-dependent oncogenesis

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20454944

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Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Gene expression profiling of pediatric acute myelogenous leukemia

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Menin critically links MLL proteins with LEDGF on cancer-associated target genes

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

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12 December 2020

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Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner

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reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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inferred from PubMed ID database lookup

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

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Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy.

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions

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reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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The MLL partial tandem duplication in acute myeloid leukaemia

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Perspectives on clonogenic tumor cells, stem cells, and oncogenes

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

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Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.

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12 December 2020

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K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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A stem cell model of human tumor growth: implications for tumor cell clonogenic assays.

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Oncogenic Transcription Factors in the Human Acute Leukemias

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12 December 2020

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Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PHD fingers of MLL block MLL fusion protein-mediated transformation

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Common mechanism for oncogenic activation of MLL by forkhead family proteins

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

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reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4 : 11) abnormality

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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reference URL

https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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HOXA9 is required for survival in human MLL-rearranged acute leukemias

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

hDOT1L links histone methylation to leukemogenesis

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia.

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

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Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia

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12 December 2020

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Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells.

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12 December 2020

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

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12 December 2020

based on heuristic

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Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

1 reference

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

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12 December 2020

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PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

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MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

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Prognostically useful gene-expression profiles in acute myeloid leukemia.

1 reference

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12 December 2020

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Therapeutic targeting of MLL.

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12 December 2020

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New insights to the MLL recombinome of acute leukemias

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12 December 2020

based on heuristic

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The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

1 reference

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

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https://pubmed.ncbi.nlm.nih.gov/20454944

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered Hox expression and segmental identity in Mll-mutant mice

1 reference

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12 December 2020

based on heuristic

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Malignant transformation initiated by Mll-AF9: gene dosage and critical target cells

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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12 December 2020

based on heuristic

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ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias

1 reference

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12 December 2020

based on heuristic

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Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia

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12 December 2020

based on heuristic

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Modeling the initiation and progression of human acute leukemia in mice

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12 December 2020

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Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors

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12 December 2020

based on heuristic

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The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

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12 December 2020

based on heuristic

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Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML).

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12 December 2020

based on heuristic

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H3K79 methylation profiles define murine and human MLL-AF4 leukemias

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12 December 2020

based on heuristic

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Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein

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https://pubmed.ncbi.nlm.nih.gov/20454944

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12 December 2020

based on heuristic

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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12 December 2020

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Identifiers

DOI

10.1007/S12185-010-0579-8

1 reference

stated in

Europe PubMed Central

PubMed publication ID

20454944

retrieved

13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

PubMed publication ID

20454944

1 reference

stated in

Europe PubMed Central

PubMed publication ID

20454944

retrieved

13 May 2018

reference URL

http://europepmc.org/abstract/MED/20454944

 

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