MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. (Q35898171)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

title

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Nan Zhu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Amit U Sinha

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Sridhar Vempati

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Joerg Faber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Zhaohui Feng

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Natalie Punt

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Amanda Daigle

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Lars Bullinger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Roy M Pollock

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Victoria M Richon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

Scott A Armstrong

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

publication date

1 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

page(s)

66-78

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis

7 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

DNMT3A Mutations in Acute Myeloid Leukemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Early mammalian erythropoiesis requires the Dot1L methyltransferase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Misguided transcriptional elongation causes mixed lineage leukemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Histone methyltransferases in cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

H3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

MLL translocations, histone modifications and leukaemia stem-cell development

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

DNA methylation as a therapeutic target in cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

hDOT1L links histone methylation to leukemogenesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Structure of the catalytic domain of human DOT1L, a non-SET domain nucleosomal histone methyltransferase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

MLL targets SET domain methyltransferase activity to Hox gene promoters

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

The kit receptor and its ligand, steel factor, as regulators of hemopoiesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

Gene expression profiling of pediatric acute myelogenous leukemia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

VavCre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329803

A conserved, extended chromatin opening within alpha-globin locus during development

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21741597

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21741597

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2011.06.010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

PubMed publication ID

21741597

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21741597%20AND%20SRC:MED&resulttype=core&format=json