Mechanisms of Gene-Environment Interactions in Parkinson's Disease (Q39247520)

10 September 2017

title

Mechanisms of Gene-Environment Interactions in Parkinson's Disease (English)

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10 September 2017

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Sheila M Fleming

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10 September 2017

publication date

17 April 2017

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Current Environmental Health Reports

10 September 2017

published in

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10 September 2017

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10 September 2017

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10 September 2017

page(s)

192-199

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Premotor and nonmotor features of Parkinson's disease

10 September 2017

cites work

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease

21 January 2018

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An essay on the shaking palsy. 1817.

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Increased nigral iron content in postmortem parkinsonian brain

21 January 2018

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Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases

21 January 2018

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Parkinson disease in twins: an etiologic study

21 January 2018

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Manganese Homeostasis and Transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Iron-binding characteristics of neuromelanin of the human substantia nigra.

21 January 2018

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Environmental risk factors and Parkinson's disease: a case-control study in Taiwan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Parkinson's disease and exposure to agricultural work and pesticide chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Paraquat neurotoxicity is distinct from that of MPTP and rotenone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Role of oxidative stress in paraquat-induced dopaminergic cell degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Parkinson's disease and brain levels of organochlorine pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Immunohistochemical Changes in the Mouse Striatum Induced by the Pyrethroid Insecticide Permethrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Pyrethroid pesticide-induced alterations in dopamine transporter function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Organochlorine insecticides in substantia nigra in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Elevated serum pesticide levels and risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

β-Hexachlorocyclohexane levels in serum and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Functional paraoxonase 1 variants modify the risk of Parkinson's disease due to organophosphate exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Household organophosphorus pesticide use and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Role of alpha-synuclein in presynaptic dopamine recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

alpha-Synuclein and neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Alpha-synuclein up-regulation in substantia nigra dopaminergic neurons following administration of the parkinsonian toxin MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

LRRK2 inhibition attenuates microglial inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

The genetics and neuropathology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

PINK1 mutations are associated with sporadic early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Clinical features and [11C]-CFT PET analysis of PARK2, PARK6, PARK7-linked autosomal recessive early onset Parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Early Expression of Parkinson's Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Characterization of the P5 subfamily of P-type transport ATPases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Cellular function and pathological role of ATP13A2 and related P-type transport ATPases in Parkinson's disease and other neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

High expression of α-synuclein in damaged mitochondria with PLA2G6 dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mitochondrial targeting sequence variants of the CHCHD2 gene are a risk for Lewy body disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Interplay of LRRK2 with chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40572-017-0143-2

Clinical manganism and exposure to manganese in the production and processing of ferromanganese alloy

21 January 2018

1 reference

12 December 2020

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1 reference

12 December 2020

Sequestration of iron by Lewy bodies in Parkinson's disease

1 reference

12 December 2020

A common LRRK2 mutation in idiopathic Parkinson's disease

1 reference

12 December 2020

Paraoxonase 1 Met--Leu 54 polymorphism is associated with Parkinson's disease

1 reference

12 December 2020

Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter.

1 reference

12 December 2020

Parkinson's disease mortality and the industrial use of heavy metals in Michigan

1 reference

12 December 2020

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

12 December 2020

Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group

1 reference

12 December 2020

Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease

1 reference

12 December 2020

10.1007/S40572-017-0143-2

Identifiers

DOI

1 reference

release_cxp7bbddzbddxnoxfr34x2f7ha

10 September 2017

Fatcat ID

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