Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration (Q50479107)

14 March 2018

title

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration (English)

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14 March 2018

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Maria Xilouri

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14 March 2018

Oeystein Roed Brekk

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14 March 2018

Natalie Landeck

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14 March 2018

Pothitos M Pitychoutis

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14 March 2018

Themistoklis Papasilekas

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14 March 2018

Zoi Papadopoulou-Daifoti

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14 March 2018

Deniz Kirik

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14 March 2018

Leonidas Stefanis

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14 March 2018

language of work or name

English

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publication date

11 June 2013

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14 March 2018

published in

Brain

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14 March 2018

volume

136

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14 March 2018

issue

Pt 7

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14 March 2018

page(s)

2130-2146

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14 March 2018

Staging of brain pathology related to sporadic Parkinson's disease

cites work

1 reference

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Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy

21 January 2018

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Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

21 January 2018

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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

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The biochemistry of Parkinson's disease

21 January 2018

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Regulation of lamp2a levels in the lysosomal membrane

21 January 2018

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21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

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GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease

21 January 2018

1 reference

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Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

21 January 2018

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Novel tools for production and purification of recombinant adenoassociated virus vectors

21 January 2018

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A simplified system for generating recombinant adenoviruses

21 January 2018

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Ageing, neurodegeneration and Parkinson's disease

21 January 2018

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Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

21 January 2018

1 reference

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Methods to monitor chaperone-mediated autophagy

21 January 2018

1 reference

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Controlling the mass action of alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

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Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease

21 January 2018

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Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra

21 January 2018

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Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway

21 January 2018

1 reference

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Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

21 January 2018

1 reference

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Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

21 January 2018

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Use of viral vectors to create animal models for Parkinson's disease

21 January 2018

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Genetic mouse models of Parkinson's disease The state of the art.

21 January 2018

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Lysosomal degradation of alpha-synuclein in vivo.

21 January 2018

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Autophagy and neurodegeneration: when the cleaning crew goes on strike

21 January 2018

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Autophagy and misfolded proteins in neurodegeneration

21 January 2018

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.

21 January 2018

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Neurochemical and behavioral alterations in an inflammatory model of depression: sex differences exposed

21 January 2018

1 reference

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

α-Synuclein in Lewy bodies

21 January 2018

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Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease

21 January 2018

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Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease

21 January 2018

1 reference

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Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons

21 January 2018

1 reference

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Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

α-Synuclein and protein degradation systems: a reciprocal relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWT131

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWT131

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14 March 2018

release_pc7lmixxtbfqpirficnsl5ybvq

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pc7lmixxtbfqpirficnsl5ybvq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

14 March 2018