LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity (Q41646475)

6 October 2017

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity (English)

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6 October 2017

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Senthilkumar S Karuppagounder

11 June 2020

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11 June 2020

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11 June 2020

Yulan Xiong

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11 June 2020

Maeve C Lawless

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11 June 2020

Donghyun Kim

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11 June 2020

Emily Nordquist

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11 June 2020

Ian Martin

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11 June 2020

Saurav Brahmachari

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11 June 2020

Aanishaa Jhaldiyal

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11 June 2020

Manoj Kumar

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11 June 2020

Shaida A Andrabi

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11 June 2020

Valina L Dawson

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11 June 2020

Ted M Dawson

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11 June 2020

publication date

22 January 2016

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Journal of Chemical Neuroanatomy

6 October 2017

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11 June 2020

volume

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issue

Pt B

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11 June 2020

page(s)

90-97

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describes a project that uses

11 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4958044/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins.

1 reference

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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

6 June 2018

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Parkinson's disease: animal models and dopaminergic cell vulnerability

6 June 2018

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Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes

6 June 2018

1 reference

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LRRK2 pathobiology in Parkinson's disease

6 June 2018

1 reference

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The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

6 June 2018

1 reference

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Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

6 June 2018

1 reference

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Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model

6 June 2018

1 reference

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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

6 June 2018

1 reference

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Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

6 June 2018

1 reference

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Classic and new animal models of Parkinson's disease

6 June 2018

1 reference

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Platelet-derived growth factors and their receptors in normal and malignant hematopoiesis

6 June 2018

1 reference

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ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

6 June 2018

1 reference

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Investigate the chronic neurotoxic effects of diquat.

6 June 2018

1 reference

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Recent advances in the genetics of Parkinson's disease

6 June 2018

1 reference

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

6 June 2018

1 reference

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Genetic animal models of Parkinson's disease

6 June 2018

1 reference

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GTPase activity plays a key role in the pathobiology of LRRK2.

6 June 2018

1 reference

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Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

6 June 2018

1 reference

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

6 June 2018

1 reference

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Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

6 June 2018

1 reference

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LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

6 June 2018

1 reference

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6 June 2018

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Protocol for the MPTP mouse model of Parkinson's disease

6 June 2018

1 reference

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

6 June 2018

1 reference

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Parkinsonism, Lrrk2 G2019S, and tau neuropathology

6 June 2018

1 reference

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

6 June 2018

1 reference

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Diagnosis and treatment of Parkinson disease: molecules to medicine

6 June 2018

1 reference

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The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat.

6 June 2018

1 reference

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

6 June 2018

1 reference

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Design-based stereology in neuroscience

6 June 2018

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

6 June 2018

1 reference

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New insights into Parkinson?s disease

6 June 2018

1 reference

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Behavioral phenotyping of mice in pharmacological and toxicological research

6 June 2018

1 reference

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Environmental factors in Parkinson's disease

6 June 2018

1 reference

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Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

6 June 2018

1 reference

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Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior

6 June 2018

1 reference

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Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

6 June 2018

1 reference

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Role of astrocytes in MPTP metabolism and toxicity

6 June 2018

1 reference

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IFNgamma regulates PDGF-receptor alpha expression in macrophages, THP-1 cells, and arterial smooth muscle cells.

6 June 2018

1 reference

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Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach.

18 August 2018

1 reference

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Genetic and environmental risk factors in Parkinson's disease

18 August 2018

1 reference

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10.1016/J.JCHEMNEU.2016.01.007

18 August 2018

Identifiers

DOI

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11 June 2020

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11 June 2020

PubMed publication ID

26808467

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26808467%20AND%20SRC:MED&resulttype=core&format=json