Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity (Q37683630)

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scientific article published on April 1985

Language	Label	Description	Also known as
English	Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity	scientific article published on April 1985

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity (English)

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

0 references

Parkinson's disease

1 reference

based on heuristic

inferred from title

Stephen M. Strittmatter

3

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Solomon Halbert Snyder

4

object named as

S H Snyder

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

author name string

J A Javitch

1

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

R J D'Amato

2

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

language of work or name

0 references

publication date

1 April 1985

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

82

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

2173-2177

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Protein measurement with the Folin phenol reagent

1 reference

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The brain-stem lesions in Parkinsonism

1 reference

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

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Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons

1 reference

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23 August 2017

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: characterization and localization of receptor binding sites in rat and human brain

1 reference

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Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1 reference

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Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1 reference

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1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1 reference

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23 August 2017

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

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Blockade of monoamine uptake by 1-amino-4-phenylbicyclo(2,2,2)octane (EXP 561) in rat brain and heart

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Chronic parkinsonism secondary to intravenous injection of meperidine analogues

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Specificity of antisera prepared against pure bovine MAO-B.

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Repeated administration of N-methyl-4-phenyl 1,2,5,6-tetrahydropyridine to rats is not toxic to striatal dopamine neurones

1 reference

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Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice

1 reference

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Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease

1 reference

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Brain enzyme is the target of drug toxin

1 reference

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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1 reference

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High-affinity binding sites for [3H]MPTP may correspond to monamine oxidase

1 reference

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Reduction of dopamine uptake and cocaine binding in mouse striatum by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1 reference

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23 June 2018

Neurochemical and behavioral effects of systematic and intranigral administration of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat

1 reference

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Effect of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) on monoamine neurotransmitters in mouse brain & heart

1 reference

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Localization of catecholamine uptake in rat brain slices.

1 reference

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Characterization of [3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes

1 reference

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Acute administration of 1-N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a compound producing parkinsonism in humans, stimulates [2-14C]deoxyglucose uptake in the regions of the catecholaminergic cell bodies in the rat and guinea pig brains

1 reference

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N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) affects locomotor activity without producing a nigrostriatal lesion in the rat

1 reference

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Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

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Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

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3Hmazindol binding associated with neuronal dopamine and norepinephrine uptake sites

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Quantitative autoradiography of [3H]MPTP binding sites in rat brain

1 reference

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A practical computer-based approach to the analysis of radioligand binding experiments

1 reference

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inferred from PubMed ID database lookup

Neurotoxicity of the meperidine analogue N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse

1 reference

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inferred from PubMed ID database lookup

The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1073/PNAS.82.7.2173

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

1985PNAS...82.2173J

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24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

22 August 2017

ResearchGate publication ID

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