Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration. (Q36066469)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration (English)

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2 February 2020

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2 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Marta Martinez-vicente

series ordinal

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2 February 2020

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2 February 2020

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2 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Anne Vital

1 reference

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2 February 2020

Christine Klein

1 reference

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2 February 2020

Celine Perier

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2 February 2020

language of work or name

English

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publication date

30 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

2 February 2020

published in

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2 February 2020

volume

109

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2 February 2020

issue

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2 February 2020

page(s)

9611-9616

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json

Fighting neurodegeneration with rapamycin: mechanistic insights

2 February 2020

cites work

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Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

2 October 2017

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Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death

2 October 2017

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Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases

2 October 2017

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Recent advances in the genetics of Parkinson's disease

2 October 2017

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Pathogenic effects of novel mutations in the P-type ATPase ATP13A2 (PARK9) causing Kufor-Rakeb syndrome, a form of early-onset parkinsonism

2 October 2017

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

2 October 2017

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Pathogenic lysosomal depletion in Parkinson's disease

2 October 2017

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Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders

2 October 2017

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Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo

2 October 2017

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Lysosomal degradation of alpha-synuclein in vivo.

2 October 2017

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

2 October 2017

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Molecular and cellular basis of lysosomal transmembrane protein dysfunction

2 October 2017

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Lysosomal membrane permeabilization in cell death

2 October 2017

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Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

2 October 2017

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Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

2 October 2017

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Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

2 October 2017

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Lysosomes: fusion and function

2 October 2017

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ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease

2 October 2017

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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

2 October 2017

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Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews

2 October 2017

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

2 October 2017

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2 October 2017

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Membrane dynamics and the biogenesis of lysosomes

2 October 2017

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Pallido-pyramidal degeneration, supranuclear upgaze paresis and dementia: Kufor-Rakeb syndrome

2 October 2017

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Cd2+, Mn2+, Ni2+ and Se2+ toxicity to Saccharomyces cerevisiae lacking YPK9p the orthologue of human ATP13A2

2 October 2017

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Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9).

11 July 2018

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Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions

23 September 2018

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

23 September 2018

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23 September 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

23 September 2018

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Lysosomal membrane permeabilization in Parkinson disease

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22647602

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Etiology and pathogenesis of Parkinson's disease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22647602

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22647602

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1112368109

1 reference

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2 February 2020

0 references

1 reference

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2 February 2020

PubMed publication ID

22647602

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22647602%20AND%20SRC:MED&resulttype=core&format=json