Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates. (Q38665164)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Alain Van Dorsselaer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Elsa Wagner-Rousset

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Alain Beck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

François Debaene

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Guillaume Terral

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Marie-Claire Janin-Bussat

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Olivier Colas

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

publication date

22 January 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

Expert Review of Proteomics

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

157-183

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

Strategies and challenges for the next generation of therapeutic antibodies

2 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

PCSK9 inhibitors--past, present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibodies to watch in 2015

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Radioimmunoconjugates for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Immunotoxin therapy for hematologic malignancies: where are we heading?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Armed antibodies for cancer treatment: a promising tool in a changing era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

The benefit of HER2-targeted therapies on overall survival of patients with metastatic HER2-positive breast cancer--a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Review of Antibody-Drug Conjugates, Methods in Molecular Biology series: A book edited by Laurent Ducry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

World Antibody-Drug Conjugate Summit, October 15-16, 2013, San Francisco, CA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody-drug conjugates: present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Current methods for the synthesis of homogeneous antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

World Antibody Drug Conjugate Summit Europe: February 21-23, 2011; Frankfurt, Germany

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody-drug conjugates: an emerging concept in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

21 January 2018

Antibody-drug conjugates

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody-drug conjugates for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

SAR3419: an anti-CD19-Maytansinoid Immunoconjugate for the treatment of B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Considerations for the nonclinical safety evaluation of antibody drug conjugates for oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Engineered antibody-drug conjugates with defined sites and stoichiometries of drug attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Transglutaminase-based chemo-enzymatic conjugation approach yields homogeneous antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectrometric characterization of transglutaminase based site-specific antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Chemoenzymatic Fc glycosylation via engineered aldehyde tags.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

MAPN: First-in-Class Reagent for Kinetically Resolved Thiol-to-Thiol Conjugation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Effect of attachment site on stability of cleavable antibody drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Site-specific conjugation improves therapeutic index of antibody drug conjugates with high drug loading

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analytical and bioanalytical technologies for characterizing antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

9th annual European Antibody Congress, November 11-13, 2013, Geneva, Switzerland

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analytical methods for physicochemical characterization of antibody drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Drug-to-antibody ratio (DAR) by UV/Vis spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Profiling antibody drug conjugate positional isomers: a system-of-equations approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Drug-to-antibody ratio (DAR) and drug load distribution by hydrophobic interaction chromatography and reversed phase high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Monoclonal antibody conjugates of doxorubicin prepared with branched peptide linkers: inhibition of aggregation by methoxytriethyleneglycol chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Synthesis and preliminary biological evaluation of high-drug-load paclitaxel-antibody conjugates for tumor-targeted chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

A reversed-phase high-performance liquid chromatography method for analysis of monoclonal antibody-maytansinoid immunoconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of therapeutic antibodies and related products.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Cutting-edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analysis of intact monoclonal antibody IgG1 by electron transfer dissociation Orbitrap FTMS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Structural analysis of intact monoclonal antibodies by electron transfer dissociation mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Top-down structural analysis of an intact monoclonal antibody by electron capture dissociation-Fourier transform ion cyclotron resonance-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Innovative native MS methodologies for antibody drug conjugate characterization: High resolution native MS and IM-MS for average DAR and DAR distribution assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Dynamic protein ligand interactions--insights from MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectrometric methods to analyze the structural organization of macromolecular complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Sizing up large protein complexes by electrospray ionisation-based electrophoretic mobility and native mass spectrometry: morphology selective binding of Fabs to hepatitis B virus capsids

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectrometry for the biophysical characterization of therapeutic monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Performing native mass spectrometry analysis on therapeutic antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Development of a native nanoelectrospray mass spectrometry method for determination of the drug-to-antibody ratio of antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Proteoform: a single term describing protein complexity

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mapping intact protein isoforms in discovery mode using top-down proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of variable regions of monoclonal antibodies by top-down mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody-drug conjugate model fast characterization by LC-MS following IdeS proteolytic digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Method to convert N-terminal glutamine to pyroglutamate for characterization of recombinant monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Drug-to-antibody ratio (DAR) and drug load distribution by LC-ESI-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of antibody drug conjugate positional isomers at cysteine residues by peptide mapping LC-MS analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analysis of post-translational modifications in recombinant monoclonal antibody IgG1 by reversed-phase liquid chromatography/mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Identification of cysteinylation of a free cysteine in the Fab region of a recombinant monoclonal IgG1 antibody using Lys-C limited proteolysis coupled with LC/MS analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of cysteine-linked conjugation profiles of immunoglobulin G1 and immunoglobulin G2 antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analysis of the composition of immunoconjugates using size-exclusion chromatography coupled to mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Determination of charge heterogeneity and level of unconjugated antibody by imaged cIEF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectral analyses of labile DOTA-NHS and heterogeneity determination of DOTA or DM1 conjugated anti-PSMA antibody for prostate cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Structural characterization of a recombinant monoclonal antibody by electrospray time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Conjugation site heterogeneity causes variable electrostatic properties in Fc conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Site-specific antibody drug conjugates for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Contribution of linker stability to the activities of anticancer immunoconjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Long-term stabilization of maleimide-thiol conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Metabolic engineering of monoclonal antibody carbohydrates for antibody-drug conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Glycans of Antibodies as a Specific Site for Drug Conjugation Using Glycosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Unnatural amino acids in novel antibody conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody-drug conjugates: current status and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Highly aggregated antibody therapeutics can enhance the in vitro innate and late-stage T-cell immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Effects of protein aggregates: an immunologic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Classification and Characterization of Therapeutic Antibody Aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Solid-state mAbs and ADCs subjected to heat-stress stability conditions can be covalently modified with buffer and excipient molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

On the Analytical Superiority of 1D NMR for Fingerprinting the Higher Order Structure of Protein Therapeutics Compared to Multidimensional NMR Methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

The solution structures of two human IgG1 antibodies show conformational stability and accommodate their C1q and FcγR ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Functional assessment of antibody oxidation by native mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Probing hemoglobin structure by means of traveling-wave ion mobility mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Evidence for macromolecular protein rings in the absence of bulk water.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

The utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Conformation and dynamics of biopharmaceuticals: transition of mass spectrometry-based tools from academe to industry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Epitope mapping of 7S cashew antigen in complex with antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Epitope mapping of inhibitory antibodies targeting the C2 domain of coagulation factor VIII by hydrogen-deuterium exchange mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Epitope mapping of antibodies by mass spectroscopy: a case study

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mapping of discontinuous conformational epitopes by amide hydrogen/deuterium exchange mass spectrometry and computational docking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

A New Approach to Explore the Impact of Freeze-Thaw Cycling on Protein Structure: Hydrogen/Deuterium Exchange Mass Spectrometry (HX-MS)

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Investigating monoclonal antibody aggregation using a combination of H/DX-MS and other biophysical measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Post-translational modifications differentially affect IgG1 conformation and receptor binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Understanding the conformational impact of chemical modifications on monoclonal antibodies with diverse sequence variation using hydrogen/deuterium exchange mass spectrometry and structural modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analytical Aspects of Hydrogen Exchange Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Approaches to Interchain Cysteine-Linked ADC Characterization by Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Fast Comparative Structural Characterization of Intact Therapeutic Antibodies Using Hydrogen-Deuterium Exchange and Electron Transfer Dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Investigation into temperature-induced aggregation of an antibody drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Auristatin antibody drug conjugate physical instability and the role of drug payload

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Photoinduced aggregation of a model antibody-drug conjugate

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Identification of Amino Acid Residues Responsible for the Release of Free Drug from an Antibody–Drug Conjugate Utilizing Lysine–Succinimidyl Ester Chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

A size exclusion-reversed phase two dimensional-liquid chromatography methodology for stability and small molecule related species in antibody drug conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Bioanalysis of antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Advances in the Development of Site-Specific Antibody-Drug Conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Challenges in antibody-drug conjugate discovery: a bioconjugation and analytical perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

In vivo biotransformations of antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody-drug conjugates nonclinical support: from early to late nonclinical bioanalysis using ligand-binding assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Workshop Report: AAPS Workshop on Method Development, Validation, and Troubleshooting of Ligand-Binding Assays in the Regulated Environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Sensitive ELISA Method for the Measurement of Catabolites of Antibody-Drug Conjugates (ADCs) in Target Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Immunogenicity assays for antibody-drug conjugates: case study with ado-trastuzumab emtansine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Critical comparison of MS and immunoassays for the bioanalysis of therapeutic antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Absolute quantification of monoclonal antibodies in biofluids by liquid chromatography-tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Mass spectrometry protocol for the absolute quantification of a monoclonal antibody in serum with immunopurification

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Absolute and multiplex quantification of antibodies in serum using PSAQ™ standards and LC-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Bioanalysis of recombinant proteins and antibodies by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Acidified acetonitrile and methanol extractions for quantitative analysis of acylcarnitines in plasma by stable isotope dilution tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Bioanalysis of antibody-drug conjugates: American Association of Pharmaceutical Scientists Antibody-Drug Conjugate Working Group position paper

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-Drug-Conjugate in Cynomolgus Monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of the drug-to-antibody ratio distribution for antibody-drug conjugates in plasma/serum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Integration of bioanalytical measurements using PK-PD modeling and simulation: implications for antibody-drug conjugate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Comparative clinical pharmacokinetics of antibody-drug conjugates in first-in-human Phase 1 studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

An FDA oncology analysis of antibody-drug conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of the N-terminal heterogeneities of monoclonal antibodies using in-gel charge derivatization of α-amines and LC-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Rapid and multi-level characterization of trastuzumab using sheathless capillary electrophoresis-tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Monoclonal antibodies biosimilarity assessment using transient isotachophoresis capillary zone electrophoresis-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Full antibody primary structure and microvariant characterization in a single injection using transient isotachophoresis and sheathless capillary electrophoresis-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Glycoform Separation and Characterization of Cetuximab Variants by Middle-up Off-Line Capillary Zone Electrophoresis-UV/Electrospray Ionization-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Analysis of monoclonal antibody by a novel CE-UV/MALDI-MS interface.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Correct primary structure assessment and extensive glyco-profiling of cetuximab by a combination of intact, middle-up, middle-down and bottom-up ESI and MALDI mass spectrometry techniques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Direct identification of rituximab main isoforms and subunit analysis by online selective comprehensive two-dimensional liquid chromatography-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Theory and practice of size exclusion chromatography for the analysis of protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Current frontiers in clinical research application of MALDI imaging mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Monitoring therapeutic monoclonal antibodies in brain tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

21 January 2018

Bispecific antibodies

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Dynamics of Intact Immunoglobulin G Explored by Drift-Tube Ion-Mobility Mass Spectrometry and Molecular Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Antibody–Drug Conjugates for Tumor Targeting—Novel Conjugation Chemistries and the Promise of non-IgG Binding Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14789450.2016.1132167

10.1586/14789450.2016.1132167

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json

release_xjkkkqcaknhhddtmtwdl3ib5su

2 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xjkkkqcaknhhddtmtwdl3ib5su

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26653789%20AND%20SRC:MED&resulttype=core&format=json