Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues. (Q36820693)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161903%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues (English)

1 reference

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19 February 2020

1 reference

1 reference

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19 February 2020

1 reference

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19 February 2020

Xiuling Li

1 reference

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19 February 2020

Mohosin Sarkar

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19 February 2020

Lee Pedzisa

1 reference

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19 February 2020

Thomas Kodadek

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19 February 2020

William R Roush

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19 February 2020

publication date

24 July 2015

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19 February 2020

published in

Bioconjugate Chemistry

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19 February 2020

volume

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19 February 2020

issue

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19 February 2020

page(s)

2243-2248

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A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs

19 February 2020

cites work

1 reference

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Hapten-directed spontaneous disulfide shuffling: a universal technology for site-directed covalent coupling of payloads to antibodies

29 September 2017

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Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments

29 September 2017

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Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development

29 September 2017

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Improving the serum stability of site-specific antibody conjugates with sulfone linkers

29 September 2017

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Trastuzumab emtansine: mechanisms of action and drug resistance

29 September 2017

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Antibody-drug conjugates: an emerging concept in cancer therapy

29 September 2017

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Selenium and selenocysteine: roles in cancer, health, and development

29 September 2017

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Site-specific antibody drug conjugates for cancer therapy

29 September 2017

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Antibody conjugation via one and two C-terminal selenocysteines.

29 September 2017

1 reference

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Antibody-drug conjugates in cancer therapy

29 September 2017

1 reference

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

29 September 2017

1 reference

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Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer

29 September 2017

1 reference

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Antibody-drug conjugates: targeted drug delivery for cancer

29 September 2017

1 reference

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Molecularly defined antibody conjugation through a selenocysteine interface

29 September 2017

1 reference

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Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies.

29 September 2017

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An engineered selenocysteine defines a unique class of antibody derivatives

29 September 2017

1 reference

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

29 September 2017

1 reference

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Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry

29 September 2017

1 reference

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Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4839195

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology

5 September 2018

1 reference

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Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats

5 September 2018

1 reference

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Selenium and sulfur in exchange reactions: a comparative study

5 September 2018

1 reference

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Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26161903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26161903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ACS.BIOCONJCHEM.5B00244

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26161903%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

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19 February 2020

PubMed publication ID

26161903

1 reference

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