Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (Q56864501)

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English	Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates	article

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instance of

scholarly article

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title

Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates (English)

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main subject

pharmacology

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based on heuristic

inferred from title

antibody

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based on heuristic

inferred from title

author name string

Robert P Lyon

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1

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Jocelyn R Setter

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2

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Tim D Bovee

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3

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Svetlana O Doronina

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4

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Joshua H Hunter

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5

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Martha E Anderson

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6

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Cindy L Balasubramanian

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7

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Steven M Duniho

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8

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Chris I Leiske

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9

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Fu Li

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10

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Peter D Senter

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11

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publication date

7 September 2014

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published in

Nature Biotechnology

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volume

32

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issue

10

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page(s)

1059-1062

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cites work

Maturing antibody-drug conjugate pipeline hits 30.

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https://pubmed.ncbi.nlm.nih.gov/25194818

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Development of potent monoclonal antibody auristatin conjugates for cancer therapy

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https://pubmed.ncbi.nlm.nih.gov/25194818

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Antibody-drug conjugates: an emerging concept in cancer therapy

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https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin's disease

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https://pubmed.ncbi.nlm.nih.gov/25194818

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Contribution of linker stability to the activities of anticancer immunoconjugates

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A Pictet-Spengler ligation for protein chemical modification

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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inferred from PubMed ID database lookup

Trastuzumab emtansine: the first targeted chemotherapy for treatment of breast cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catalysis of imido group hydrolysis in a maleimide conjugate

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity

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12 December 2020

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Semi-mechanistic population pharmacokinetic model of multivalent trastuzumab emtansine in patients with metastatic breast cancer

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

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Reduction-alkylation strategies for the modification of specific monoclonal antibody disulfides

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

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reference URL

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12 December 2020

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Antibody-drug conjugate (ADC) clinical pipeline: a review

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https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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A general approach to site-specific antibody drug conjugates

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12 December 2020

based on heuristic

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Advancing antibody drug conjugation: from the laboratory to a clinically approved anticancer drug

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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Conjugation of anticancer drugs through endogenous monoclonal antibody cysteine residues

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reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

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Hydrolysis of p-NN′-phenylenebismaleimide and its adducts with cysteine. Implications for cross-linking of proteins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25194818

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The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tunable degradation of maleimide-thiol adducts in reducing environments

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates in cancer therapy

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid, stable, chemoselective labeling of thiols with Julia-Kocieński-like reagents: a serum-stable alternative to maleimide-based protein conjugation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new reagent for stable thiol-specific conjugation

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stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/25194818

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NBT.2968

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PubMed publication ID

25194818

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