Medically important fungi respond to azole drugs: an update. (Q38559208)

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20 February 2020

review article

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title

Medically important fungi respond to azole drugs: an update (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26234644%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Martin Zavrel

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20 February 2020

publication date

3 August 2015

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20 February 2020

number of pages

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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20 February 2020

volume

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issue

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20 February 2020

page(s)

1355-1373

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Candidaemia in Europe: epidemiology and resistance

20 February 2020

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A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

21 January 2018

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Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans

21 January 2018

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An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans

21 January 2018

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An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

21 January 2018

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Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

21 January 2018

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TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.

21 January 2018

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21 January 2018

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The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicans

21 January 2018

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Defective sterol C5-6 desaturation and azole resistance: a new hypothesis for the mode of action of azole antifungals

21 January 2018

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Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance

21 January 2018

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Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans

21 January 2018

1 reference

Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility

21 January 2018

1 reference

Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents

21 January 2018

1 reference

Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3B: role in sterol biosynthesis and antifungal drug susceptibility.

21 January 2018

1 reference

Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae

21 January 2018

1 reference

A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance

21 January 2018

1 reference

A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans

21 January 2018

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Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.

21 January 2018

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The zinc cluster transcription factor Tac1p regulates PDR16 expression in Candida albicans

21 January 2018

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Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

21 January 2018

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Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans

21 January 2018

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A novel multidrug efflux transporter gene of the major facilitator superfamily from Candida albicans (FLU1) conferring resistance to fluconazole.

21 January 2018

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Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

21 January 2018

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Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

21 January 2018

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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

21 January 2018

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Aneuploidy and isochromosome formation in drug-resistant Candida albicans

21 January 2018

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Homozygosity at the Candida albicans MTL locus associated with azole resistance

21 January 2018

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Candida albicans pathogenicity mechanisms.

21 January 2018

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Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

21 January 2018

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The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans

21 January 2018

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Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans

21 January 2018

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Antifungal activity of amphotericin B, fluconazole, and voriconazole in an in vitro model of Candida catheter-related bloodstream infection

21 January 2018

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Resistance of Candida albicans biofilms to antifungal agents in vitro

21 January 2018

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Candida albicans biofilms: more than filamentation

21 January 2018

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Genetics and genomics of Candida albicans biofilm formation

21 January 2018

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Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms

21 January 2018

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Putative role of beta-1,3 glucans in Candida albicans biofilm resistance.

21 January 2018

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Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan.

21 January 2018

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Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The Candida glabrata putative sterol transporter gene CgAUS1 protects cells against azoles in the presence of serum

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Substitutions at methionine 220 in the 14alpha-sterol demethylase (Cyp51A) of Aspergillus fumigatus are responsible for resistance in vitro to azole antifungal drugs

21 January 2018

1 reference

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21 January 2018

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Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.

21 January 2018

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Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

21 January 2018

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Rapid detection of triazole antifungal resistance in Aspergillus fumigatus

21 January 2018

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Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing

21 January 2018

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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

21 January 2018

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Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate

21 January 2018

1 reference

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

21 January 2018

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Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity

21 January 2018

1 reference

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21 January 2018

1 reference

Resistant P45051A1 activity in azole antifungal tolerant Cryptococcus neoformans from AIDS patients.

21 January 2018

1 reference

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate

21 January 2018

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Cross-resistance to polyene and azole drugs in Cryptococcus neoformans

21 January 2018

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Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole

21 January 2018

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Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Resistance to echinocandin-class antifungal drugs

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Pharmacology of Systemic Antifungal Agents

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21 January 2018

Identifiers

DOI

10.2217/FMB.15.47

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20 February 2020

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