Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence (Q37545098)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24243794%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence (English)

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1 March 2020

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1 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24243794%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Andrea Lohberger

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1 March 2020

publication date

15 November 2013

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1 March 2020

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volume

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issue

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1 March 2020

page(s)

127-142

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Gain-of-function mutations in PDR1, a regulator of antifungal drug resistance in Candida glabrata, control adherence to host cells

1 March 2020

cites work

1 reference

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Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans

23 August 2017

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Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population-based surveillance studies in two U.S. cities from 2008 to 2011.

23 August 2017

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23 August 2017

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Azole resistance by loss of function of the sterol Δ⁵,⁶-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence

23 August 2017

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Growth of Candida albicans hyphae

23 August 2017

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Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.

23 August 2017

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Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans

23 August 2017

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Antibiotic resistance and its cost: is it possible to reverse resistance?

23 August 2017

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An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans

23 August 2017

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Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance

23 August 2017

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Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

23 August 2017

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Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.

23 August 2017

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Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence

23 August 2017

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Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

23 August 2017

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A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

23 August 2017

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The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

23 August 2017

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The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans

23 August 2017

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Genome-wide expression and location analyses of the Candida albicans Tac1p regulon.

23 August 2017

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Multidrug resistance in fungi

23 August 2017

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Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

23 August 2017

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Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae.

23 August 2017

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In vivo survival of teicoplanin-resistant Staphylococcus aureus and fitness cost of teicoplanin resistance

23 August 2017

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Candida glabrata PDR1, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants

23 August 2017

1 reference

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A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans

23 August 2017

1 reference

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TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2.

23 August 2017

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Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor

23 August 2017

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Mechanism of increased fluconazole resistance in Candida glabrata during prophylaxis

23 August 2017

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Studies on lysogenesis. I. The mode of phage liberation by lysogenic Escherichia coli

23 August 2017

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Fitness cost of chromosomal drug resistance-conferring mutations

23 August 2017

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23 August 2017

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Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

23 August 2017

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Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients

23 August 2017

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Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans

23 August 2017

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Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.

23 August 2017

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Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans

23 August 2017

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The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents.

23 August 2017

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The biological cost of antibiotic resistance

23 August 2017

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Fluconazole versus Candida albicans: a complex relationship.

23 August 2017

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Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

23 August 2017

1 reference

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Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

23 August 2017

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Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

23 August 2017

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Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

23 August 2017

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Evolutionary dynamics of Candida albicans during in vitro evolution

23 August 2017

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Epidemiology of invasive candidiasis

6 September 2017

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Genomewide location analysis of Candida albicans Upc2p, a regulator of sterol metabolism and azole drug resistance

6 September 2017

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Analysis of phase-specific gene expression at the single-cell level in the white-opaque switching system of Candida albicans

6 September 2017

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Difference in virulence between fluconazole-susceptible and fluconazole-resistant Candida albicans in a mouse model

6 September 2017

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Reduced virulence of Candida albicans mutants affected in multidrug resistance

6 September 2017

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Resistance to echinocandins comes at a cost: the impact of FKS1 hotspot mutations on Candida albicans fitness and virulence

14 September 2017

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Genomewide expression profile analysis of the Candida glabrata Pdr1 regulon

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

The central role of PDR1 in the foundation of yeast drug resistance

25 June 2018

1 reference

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A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

Antifungal resistance does not necessarily affect Candida glabrata fitness

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata

1 September 2018

1 reference

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EUCAST definitive document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts

1 September 2018

1 reference

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Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

The SAT1 flipper, an optimized tool for gene disruption in Candida albicans

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

Fitness of antibiotic resistant Staphylococcus epidermidis assessed by competition on the skin of human volunteers

1 September 2018

1 reference

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Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

Function of Candida glabrata ABC transporter gene, PDH1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910953

Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24243794

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The cost of antibiotic resistance from a bacterial perspective

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24243794

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The stepwise acquisition of fluconazole resistance mutations causes a gradual loss of fitness in Candida albicans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24243794

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/EC.00245-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24243794%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24243794%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

24243794

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24243794%20AND%20SRC:MED&resulttype=core&format=json