The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates (Q34112865)

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English	The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates (English)

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Europe PubMed Central

PubMed publication ID

31 July 2017

Candida glabrata

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1 reference

ChEBI release 2020-05-28

Candida albicans

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based on heuristic

inferred from title

object named as

Erwin Lamping

5

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ORCID Public Data File 2021

6

object named as

Larry A Sklar

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Europe PubMed Central

PubMed publication ID

31 July 2017

7

object named as

Richard D Cannon

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Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Ann R Holmes

1

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Europe PubMed Central

PubMed publication ID

31 July 2017

Mikhail V Keniya

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

Irena Ivnitski-Steele

3

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Europe PubMed Central

PubMed publication ID

31 July 2017

Brian C Monk

4

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

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publication date

27 December 2011

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Europe PubMed Central

PubMed publication ID

31 July 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

PubMed publication ID

31 July 2017

56

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Europe PubMed Central

PubMed publication ID

31 July 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1508-1515

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

1 reference

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Emerging opportunistic yeast infections

1 reference

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5 July 2018

Targeting monoamine oxidase A in advanced prostate cancer

1 reference

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5 July 2018

Safety of triazole antifungal drugs in patients with cancer

1 reference

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5 July 2018

Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload

1 reference

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Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p

1 reference

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5 July 2018

Efflux-mediated antifungal drug resistance.

1 reference

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5 July 2018

High-content screening: flow cytometry analysis

1 reference

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5 July 2018

Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance

1 reference

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5 July 2018

New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.

1 reference

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5 July 2018

Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.

1 reference

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5 July 2018

ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294898

5 July 2018

Monoamine oxidase inactivation: from pathophysiology to therapeutics

1 reference

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5 July 2018

Antimicrobial resistance: resistance to antifungal agents: mechanisms and clinical impact

1 reference

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Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

1 reference

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Antifungal potential of disulfiram.

1 reference

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5 July 2018

Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294898

5 July 2018

Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2.

1 reference

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5 July 2018

Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility

1 reference

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Modulator-induced interference in functional cross talk between the substrate and the ATP sites of human P-glycoprotein

1 reference

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1 reference

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5 July 2018

Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294898

5 July 2018

Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294898

5 July 2018

Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3294898

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Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects

1 reference

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MDR1-mediated drug resistance in Candida dubliniensis

1 reference

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Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters

1 reference

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Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.

1 reference

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Inducible azole resistance associated with a heterogeneous phenotype in Candida albicans.

1 reference

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Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation

1 reference

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Potent synergism of the combination of fluconazole and cyclosporine in Candida albicans

1 reference

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Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

1 reference

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Identification of a region important for human monoamine oxidase B substrate and inhibitor selectivity

1 reference

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1 reference

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1 reference

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1 reference

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Ibuprofen reverts antifungal resistance on Candida albicans showing overexpression of CDR genes.

1 reference

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Cerulenin analogues as inhibitors of efflux pumps in drug-resistant Candida albicans

1 reference

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Outwitting multidrug resistance to antifungals

1 reference

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1 reference

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Establishing surrogate markers for fluconazole resistance in Candida albicans

1 reference

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Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast

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Identification and expression of multidrug resistance-related ABC transporter genes in Candida krusei

1 reference

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High throughput flow cytometry

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https://pubmed.ncbi.nlm.nih.gov/22203607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergy, antagonism, and what the chequerboard puts between them

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/22203607

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.05706-11

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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