Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase. (Q37083800)

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2 January 2020

review article

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title

Mechanisms of resistance to nucleoside analogue inhibitors of HIV-1 reverse transcriptase (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18272247%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18272247%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

Luis Menéndez-Arias

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18 August 2017

publication date

12 February 2008

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2 January 2020

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2 January 2020

volume

134

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2 January 2020

issue

1-2

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2 January 2020

page(s)

124-146

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

2 January 2020

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7 January 2021

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Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

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7 January 2021

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Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase

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7 January 2021

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7 January 2021

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7 January 2021

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Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates

7 January 2021

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Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

7 January 2021

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7 January 2021

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Effectiveness of 3TC in HIV clinical trials may be due in part to the M184V substitution in 3TC-resistant HIV-1 reverse transcriptase

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in HIV-1: clinical, phenotypic and genotypic correlates

7 January 2021

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Broad Nucleoside Reverse‐Transcriptase Inhibitor Cross‐Resistance in Human Immunodeficiency Virus Type 1 Clinical Isolates

7 January 2021

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7 January 2021

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Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations

7 January 2021

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A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

7 January 2021

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Variants other than aspartic acid at codon 69 of the human immunodeficiency virus type 1 reverse transcriptase gene affect susceptibility to nuleoside analogs

7 January 2021

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Refined model for primer/template binding by HIV-1 reverse transcriptase: pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nuc

7 January 2021

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Highly selective action of triphosphate metabolite of 4'-ethynyl D4T: a novel anti-HIV compound against HIV-1 RT

7 January 2021

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N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

7 January 2021

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The structural mechanism of translocation and helicase activity in T7 RNA polymerase

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Anti-human immunodeficiency virus type 1 activity, intracellular metabolism, and pharmacokinetic evaluation of 2'-deoxy-3'-oxa-4'-thiocytidine.

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility

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7 January 2021

A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2',3'-dideoxy-3'-thiacytidine

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7 January 2021

Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val.

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7 January 2021

Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet.

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7 January 2021

Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years

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7 January 2021

10.1016/J.VIRUSRES.2007.12.015

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18272247%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18272247%20AND%20SRC:MED&resulttype=core&format=json