Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs. (Q38346006)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

title

Defining a molecular mechanism of synergy between nucleoside and nonnucleoside AIDS drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author name string

Aravind Basavapathruni

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Karen S Anderson

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

language of work or name

English

0 references

publication date

13 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

volume

279

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

page(s)

6221-6224

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

HIV inhibitors targeted at the reverse transcriptase

17 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Drug combinations and effect parameters of zidovudine, stavudine, and nevirapine in standardized drug-sensitive and resistant HIV type 1 strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Factors contributing to the inhibition of HIV reverse transcriptase by chain-terminating nucleotides in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Pre-steady-state kinetic characterization of wild type and 3'-azido-3'-deoxythymidine (AZT) resistant human immunodeficiency virus type 1 reverse transcriptase: implication of RNA directed DNA polymerization in the mechanism of AZT resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Potency of nonnucleoside reverse transcriptase inhibitors (NNRTIs) used in combination with other human immunodeficiency virus NNRTIs, NRTIs, or protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Lamivudine or stavudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

A controlled trial of nevirapine plus zidovudine versus zidovudine alone in p24 antigenaemic HIV-infected patients. The Dutch-Italian-Australian Nevirapine Study Group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase gamma: importance in mitochondrial DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300523200

21 January 2018

Identifiers

DOI

10.1074/JBC.C300523200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14722107%20AND%20SRC:MED&resulttype=core&format=json